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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei149May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciDNOD246195:G1G7U-1244-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:DNO_1248
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
Proteomesi
  • UP000000248 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975051 – 262GTP cyclohydrolase FolE2Add BLAST262

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_1248

Structurei

3D structure databases

ProteinModelPortaliA5EXB0
SMRiA5EXB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A5EXB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETAIPDVQ SSPDKRHIAI NRVGIRDLRL PLFIENAAGE AMPTVARAAL
60 70 80 90 100
MVALPHTQKG THMSRFIRLL DLKTPISVSA LPTLHQKMLD TLHAEEGTIS
110 120 130 140 150
LSFPFFIEKS APVSGEKALL DYEVVLAVDG NRKHVEVSVE VTVPVTSLCP
160 170 180 190 200
CSKEISQYGA HNQRSHIVIY AQYNPNQPFS IEDLIHIAEE GASCPIWSLL
210 220 230 240 250
KRPDEKYITE RAYEHPKFVE DIVRDIAMVL NDDPRISFYR ISSENFESIH
260
NHSAFALIEH QK
Length:262
Mass (Da):29,458
Last modified:June 12, 2007 - v1
Checksum:i27A3AF4495D54581
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000513 Genomic DNA Translation: ABQ13387.1
RefSeqiWP_012031543.1, NC_009446.1

Genome annotation databases

EnsemblBacteriaiABQ13387; ABQ13387; DNO_1248
KEGGidno:DNO_1248

Similar proteinsi

Entry informationi

Entry nameiGCH4_DICNV
AccessioniPrimary (citable) accession number: A5EXB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health