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A5EXB0

- GCH4_DICNV

UniProt

A5EXB0 - GCH4_DICNV

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, DNO_1248
Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDNOD246195:GHHS-1245-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:DNO_1248
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
ProteomesiUP000000248: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262GTP cyclohydrolase FolE2UniRule annotation
PRO_0000297505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_1248.

Structurei

3D structure databases

ProteinModelPortaliA5EXB0.
SMRiA5EXB0. Positions 17-262.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5EXB0-1 [UniParc]FASTAAdd to Basket

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MTETAIPDVQ SSPDKRHIAI NRVGIRDLRL PLFIENAAGE AMPTVARAAL    50
MVALPHTQKG THMSRFIRLL DLKTPISVSA LPTLHQKMLD TLHAEEGTIS 100
LSFPFFIEKS APVSGEKALL DYEVVLAVDG NRKHVEVSVE VTVPVTSLCP 150
CSKEISQYGA HNQRSHIVIY AQYNPNQPFS IEDLIHIAEE GASCPIWSLL 200
KRPDEKYITE RAYEHPKFVE DIVRDIAMVL NDDPRISFYR ISSENFESIH 250
NHSAFALIEH QK 262
Length:262
Mass (Da):29,458
Last modified:June 12, 2007 - v1
Checksum:i27A3AF4495D54581
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000513 Genomic DNA. Translation: ABQ13387.1.
RefSeqiWP_012031543.1. NC_009446.1.
YP_001210124.1. NC_009446.1.

Genome annotation databases

EnsemblBacteriaiABQ13387; ABQ13387; DNO_1248.
GeneIDi5123066.
KEGGidno:DNO_1248.
PATRICi21786850. VBIDicNod48475_1241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000513 Genomic DNA. Translation: ABQ13387.1 .
RefSeqi WP_012031543.1. NC_009446.1.
YP_001210124.1. NC_009446.1.

3D structure databases

ProteinModelPortali A5EXB0.
SMRi A5EXB0. Positions 17-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246195.DNO_1248.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ13387 ; ABQ13387 ; DNO_1248 .
GeneIDi 5123066.
KEGGi dno:DNO_1248.
PATRICi 21786850. VBIDicNod48475_1241.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DNOD246195:GHHS-1245-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCS1703A.

Entry informationi

Entry nameiGCH4_DICNV
AccessioniPrimary (citable) accession number: A5EXB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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