A5EX62 (MUTS_DICNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutS

Gene names

Name:	mutS
Ordered Locus Names:	DNO_1303

Organism

Dichelobacter nodosus (strain VCS1703A) [Complete proteome] [HAMAP]

Taxonomic identifier

246195 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Cardiobacteriales › Cardiobacteriaceae › Dichelobacter › Dichelobacter nodosus

Protein attributes

Sequence length	861 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096
Sequence similarities	Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: HAMAP mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 861	861	DNA mismatch repair protein MutS HAMAP-Rule MF_00096		PRO_0000335149
Regions
	Nucleotide binding	613 – 620	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A5EX62 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 6FEE71BC9C0BF0B7	FASTA	861	96,680
	10 20 30 40 50 60 MNTKISEHTP AMQQYLTIKE DFPDLLLFYR MGDFYELFFD DAKKAGALLN ITVTARGKIR 70 80 90 100 110 120 GKPIPMAGVP AHALENYLAK LVKQGMSAVI CEQVGEVGKG LVERAVTRII TPGTLTDENL 130 140 150 160 170 180 LDEARDSILL SLFCFQNNYF FAYADITRGD FQLTMGLNEQ ELQSEIERLR PAEILMPETA 190 200 210 220 230 240 NVPAFITALK PHRQPDWYFD SDSSYRLICE YYQTTTIDGF GIAPDDPALS AAGCLLQYLH 250 260 270 280 290 300 DTHKYHLPPL KPLQKQHDHQ YLLLDATTRR NLELEYTLNG ESKHSLIATI NRCSTAAGVR 310 320 330 340 350 360 TLKRWINQPL IQHEYILERQ EAVTALLTHA DLDEIAKTLR ATADIERITT RIALQTAKPR 370 380 390 400 410 420 ELAQLRDTLM QLPAINALLQ TSAAHSPLLA AATQALMHCP QLGDLLMKAL VEAPPLTLKE 430 440 450 460 470 480 GGIFAAGYLP ELDALHELTD HSAQLLEKME QEEKAQTGLN TLKIGFNRVH GYYIDIPRSQ 490 500 510 520 530 540 AANAPAHWIR RQTLKNSERY VTESLKTLEE RLLNAQDEAL ALEKQAYTEL LITLDKQRDD 550 560 570 580 590 600 LYRLATALAE SDVLTCFARL AKEHHYCRPQ FSNQIEIQIT AGRHPVVEQL SAQPFIANDL 610 620 630 640 650 660 VLHQKRQLLI LTGPNMGGKS TYMRQTALIV ILALAGSYVP AKEARIGRIN RIFTRIGASD 670 680 690 700 710 720 DLAGGRSTFM VEMTETANIL NNADEHSLVI MDEIGRGTST FDGLSLAWAV ADHLLQKNRA 730 740 750 760 770 780 LTLFATHYFE LTALVERHQH GANIHLSAAE DQEHIVFLYH IEEGATSKSY GLHVAKLAGV 790 800 810 820 830 840 PQAVIHNANA KLRQLEEKRV PQRAHQALLP IESQKPSLSP QIKNILQQIQ EINPDELSPK 850 860 AAHEWLYQLK TLVRDLDKNE L

References

[1]

"Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus." Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T., Fedorova N. , Khouri H., Bottomley S.P., Whittington R.J., Adler B., Songer J.G., Rood J.I., Paulsen I.T. Nat. Biotechnol. 25:569-575(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCS1703A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000513 Genomic DNA. Translation: ABQ13473.1.
RefSeq	YP_001210174.1. NC_009446.1.
3D structure databases
ProteinModelPortal	A5EX62.
ModBase	Search...
Protein-protein interaction databases
STRING	246195.DNO_1303.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ13473; ABQ13473; DNO_1303.
GeneID	5123365.
KEGG	dno:DNO_1303.
PATRIC	21786960. VBIDicNod48475_1292.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0249.
HOGENOM	HOG000221407.
KO	K03555.
OMA	HYFELTV.
Enzyme and pathway databases
BioCyc	DNOD246195:GHHS-1305-MONOMER.
Family and domain databases
Gene3D	3.30.420.110. 1 hit. 3.40.1170.10. 1 hit.
HAMAP	MF_00096. MutS.
InterPro	IPR005748. DNA_mismatch_repair_MutS-1. IPR007695. DNA_mismatch_repair_MutS-lik_N. IPR000432. DNA_mismatch_repair_MutS_C. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007696. DNA_mismatch_repair_MutS_core. IPR016151. DNA_mismatch_repair_MutS_N. IPR007860. DNA_mmatch_repair_MutS_con_dom. [Graphical view]
PANTHER	PTHR11361:SF34. PTHR11361:SF34. 1 hit.
Pfam	PF01624. MutS_I. 1 hit. PF05188. MutS_II. 1 hit. PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. PF00488. MutS_V. 1 hit. [Graphical view]
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF53150. DNA_mismatch_repair_MutS_connt. 1 hit. SSF55271. DNA_mismatch_repair_MutS_N. 1 hit. SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMs	TIGR01070. mutS1. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS_DICNV

Accession

Primary (citable) accession number: A5EX62

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program