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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi613 – 6208ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDNOD246195:GHHS-1300-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Ordered Locus Names:DNO_1303
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
ProteomesiUP000000248 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861DNA mismatch repair protein MutSPRO_0000335149Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_1303.

Structurei

3D structure databases

ProteinModelPortaliA5EX62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221407.
KOiK03555.
OMAiCVTPMGS.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5EX62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTKISEHTP AMQQYLTIKE DFPDLLLFYR MGDFYELFFD DAKKAGALLN
60 70 80 90 100
ITVTARGKIR GKPIPMAGVP AHALENYLAK LVKQGMSAVI CEQVGEVGKG
110 120 130 140 150
LVERAVTRII TPGTLTDENL LDEARDSILL SLFCFQNNYF FAYADITRGD
160 170 180 190 200
FQLTMGLNEQ ELQSEIERLR PAEILMPETA NVPAFITALK PHRQPDWYFD
210 220 230 240 250
SDSSYRLICE YYQTTTIDGF GIAPDDPALS AAGCLLQYLH DTHKYHLPPL
260 270 280 290 300
KPLQKQHDHQ YLLLDATTRR NLELEYTLNG ESKHSLIATI NRCSTAAGVR
310 320 330 340 350
TLKRWINQPL IQHEYILERQ EAVTALLTHA DLDEIAKTLR ATADIERITT
360 370 380 390 400
RIALQTAKPR ELAQLRDTLM QLPAINALLQ TSAAHSPLLA AATQALMHCP
410 420 430 440 450
QLGDLLMKAL VEAPPLTLKE GGIFAAGYLP ELDALHELTD HSAQLLEKME
460 470 480 490 500
QEEKAQTGLN TLKIGFNRVH GYYIDIPRSQ AANAPAHWIR RQTLKNSERY
510 520 530 540 550
VTESLKTLEE RLLNAQDEAL ALEKQAYTEL LITLDKQRDD LYRLATALAE
560 570 580 590 600
SDVLTCFARL AKEHHYCRPQ FSNQIEIQIT AGRHPVVEQL SAQPFIANDL
610 620 630 640 650
VLHQKRQLLI LTGPNMGGKS TYMRQTALIV ILALAGSYVP AKEARIGRIN
660 670 680 690 700
RIFTRIGASD DLAGGRSTFM VEMTETANIL NNADEHSLVI MDEIGRGTST
710 720 730 740 750
FDGLSLAWAV ADHLLQKNRA LTLFATHYFE LTALVERHQH GANIHLSAAE
760 770 780 790 800
DQEHIVFLYH IEEGATSKSY GLHVAKLAGV PQAVIHNANA KLRQLEEKRV
810 820 830 840 850
PQRAHQALLP IESQKPSLSP QIKNILQQIQ EINPDELSPK AAHEWLYQLK
860
TLVRDLDKNE L
Length:861
Mass (Da):96,680
Last modified:June 12, 2007 - v1
Checksum:i6FEE71BC9C0BF0B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000513 Genomic DNA. Translation: ABQ13473.1.
RefSeqiWP_012031593.1. NC_009446.1.

Genome annotation databases

EnsemblBacteriaiABQ13473; ABQ13473; DNO_1303.
KEGGidno:DNO_1303.
PATRICi21786960. VBIDicNod48475_1292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000513 Genomic DNA. Translation: ABQ13473.1.
RefSeqiWP_012031593.1. NC_009446.1.

3D structure databases

ProteinModelPortaliA5EX62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246195.DNO_1303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ13473; ABQ13473; DNO_1303.
KEGGidno:DNO_1303.
PATRICi21786960. VBIDicNod48475_1292.

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221407.
KOiK03555.
OMAiCVTPMGS.
OrthoDBiEOG6Q5NPV.

Enzyme and pathway databases

BioCyciDNOD246195:GHHS-1300-MONOMER.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCS1703A.

Entry informationi

Entry nameiMUTS_DICNV
AccessioniPrimary (citable) accession number: A5EX62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: July 22, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.