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A5EX62 (MUTS_DICNV) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutS
Gene names
Name:mutS
Ordered Locus Names:DNO_1303
OrganismDichelobacter nodosus (strain VCS1703A) [Complete proteome] [HAMAP]
Taxonomic identifier246195 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter

Protein attributes

Sequence length861 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096

Sequence similarities

Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

damaged DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 861861DNA mismatch repair protein MutS HAMAP-Rule MF_00096
PRO_0000335149

Regions

Nucleotide binding613 – 6208ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A5EX62 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 6FEE71BC9C0BF0B7

FASTA86196,680
        10         20         30         40         50         60 
MNTKISEHTP AMQQYLTIKE DFPDLLLFYR MGDFYELFFD DAKKAGALLN ITVTARGKIR 

        70         80         90        100        110        120 
GKPIPMAGVP AHALENYLAK LVKQGMSAVI CEQVGEVGKG LVERAVTRII TPGTLTDENL 

       130        140        150        160        170        180 
LDEARDSILL SLFCFQNNYF FAYADITRGD FQLTMGLNEQ ELQSEIERLR PAEILMPETA 

       190        200        210        220        230        240 
NVPAFITALK PHRQPDWYFD SDSSYRLICE YYQTTTIDGF GIAPDDPALS AAGCLLQYLH 

       250        260        270        280        290        300 
DTHKYHLPPL KPLQKQHDHQ YLLLDATTRR NLELEYTLNG ESKHSLIATI NRCSTAAGVR 

       310        320        330        340        350        360 
TLKRWINQPL IQHEYILERQ EAVTALLTHA DLDEIAKTLR ATADIERITT RIALQTAKPR 

       370        380        390        400        410        420 
ELAQLRDTLM QLPAINALLQ TSAAHSPLLA AATQALMHCP QLGDLLMKAL VEAPPLTLKE 

       430        440        450        460        470        480 
GGIFAAGYLP ELDALHELTD HSAQLLEKME QEEKAQTGLN TLKIGFNRVH GYYIDIPRSQ 

       490        500        510        520        530        540 
AANAPAHWIR RQTLKNSERY VTESLKTLEE RLLNAQDEAL ALEKQAYTEL LITLDKQRDD 

       550        560        570        580        590        600 
LYRLATALAE SDVLTCFARL AKEHHYCRPQ FSNQIEIQIT AGRHPVVEQL SAQPFIANDL 

       610        620        630        640        650        660 
VLHQKRQLLI LTGPNMGGKS TYMRQTALIV ILALAGSYVP AKEARIGRIN RIFTRIGASD 

       670        680        690        700        710        720 
DLAGGRSTFM VEMTETANIL NNADEHSLVI MDEIGRGTST FDGLSLAWAV ADHLLQKNRA 

       730        740        750        760        770        780 
LTLFATHYFE LTALVERHQH GANIHLSAAE DQEHIVFLYH IEEGATSKSY GLHVAKLAGV 

       790        800        810        820        830        840 
PQAVIHNANA KLRQLEEKRV PQRAHQALLP IESQKPSLSP QIKNILQQIQ EINPDELSPK 

       850        860 
AAHEWLYQLK TLVRDLDKNE L 

« Hide

References

[1]"Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus."
Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T., Fedorova N. expand/collapse author list , Khouri H., Bottomley S.P., Whittington R.J., Adler B., Songer J.G., Rood J.I., Paulsen I.T.
Nat. Biotechnol. 25:569-575(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VCS1703A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000513 Genomic DNA. Translation: ABQ13473.1.
RefSeqYP_001210174.1. NC_009446.1.

3D structure databases

ProteinModelPortalA5EX62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246195.DNO_1303.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ13473; ABQ13473; DNO_1303.
GeneID5123365.
KEGGdno:DNO_1303.
PATRIC21786960. VBIDicNod48475_1292.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHOG000221407.
KOK03555.
OMAMMAQYLE.
OrthoDBEOG6Q5NPV.

Enzyme and pathway databases

BioCycDNOD246195:GHHS-1300-MONOMER.

Family and domain databases

Gene3D3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00096. MutS.
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS_DICNV
AccessionPrimary (citable) accession number: A5EX62
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families