A5EWU9 (PTH_DICNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	DNO_0063

Organism

Dichelobacter nodosus (strain VCS1703A) [Complete proteome] [HAMAP]

Taxonomic identifier

246195 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Cardiobacteriales › Cardiobacteriaceae › Dichelobacter › Dichelobacter nodosus

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP-Rule MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP-Rule MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Peptidyl-tRNA hydrolase HAMAP-Rule MF_00083		PRO_1000071227

Sequences

	Sequence		Length	Mass (Da)
	A5EWU9 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: B1B573F3D77BE8FA	FASTA	189	21,405
	10 20 30 40 50 60 MLKLIVGLGN PGEQYQKTRH NAGFWLLDQT AQDYSCRLRT EKKFFAEFGE IAINQQKIFL 70 80 90 100 110 120 LKPQTFMNAS GKSLAAVCRF YHIEPQQILI IHDELDLPEG KIKLKKSGGH GGHNGLRDII 130 140 150 160 170 180 AALASQDFYR LRIGIGRPEN STQVIDYVLK APSATHMERL NESLSYGKKA IEKLITEGDE KAMHWLHSL

References

[1]

"Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus." Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T., Fedorova N. , Khouri H., Bottomley S.P., Whittington R.J., Adler B., Songer J.G., Rood J.I., Paulsen I.T. Nat. Biotechnol. 25:569-575(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCS1703A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000513 Genomic DNA. Translation: ABQ13985.1.
RefSeq	YP_001208995.1. NC_009446.1.
3D structure databases
ProteinModelPortal	A5EWU9.
ModBase	Search...
Protein-protein interaction databases
STRING	246195.DNO_0063.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ13985; ABQ13985; DNO_0063.
GeneID	5122736.
KEGG	dno:DNO_0063.
PATRIC	21784412. VBIDicNod48475_0059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HOG000004796.
KO	K01056.
OMA	VINWVLK.
Enzyme and pathway databases
BioCyc	DNOD246195:GHHS-110-MONOMER.
Family and domain databases
Gene3D	3.40.50.1470. 1 hit.
HAMAP	MF_00083. Pept_tRNA_hydro_bact.
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
PANTHER	PTHR17224. PTHR17224. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_DICNV

Accession

Primary (citable) accession number: A5EWU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program