A5EWS0 (AROA_DICNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	DNO_0111

Organism

Dichelobacter nodosus (strain VCS1703A) [Complete proteome] [HAMAP]

Taxonomic identifier

246195 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Cardiobacteriales › Cardiobacteriaceae › Dichelobacter

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000058596

Sequences

	Sequence		Length	Mass (Da)
	A5EWS0 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 0713251B38EDEF0F	FASTA	442	47,401
	10 20 30 40 50 60 MTNIWHTAPV SALSGEITIC GDKSMSHRAL LLAALAEGQT EIRGFLPCAD CLATAQALRA 70 80 90 100 110 120 LWVDIQREKE IVTIRGVGFL GLQPPKAPLN MQNSGTSMRL LAGILAAQRF ESVLCGDESL 130 140 150 160 170 180 EKRPMQRIIT PLVQMGAKIV SHSNFTAPLH ISGRPLTGID YALPLPSAQL KSCLILAGLL 190 200 210 220 230 240 ADGTTRLHTC GISRDHTERM LPLFGGALET QKEQIIVTGG QKLHGCVLEI VGDLSAAAFF 250 260 270 280 290 300 MVAALIAPRA EVVIRNVGIN PTRSAIITLL QKMGGRIELH HQRFWGAEPV ADIVVYHSKL 310 320 330 340 350 360 RGITVAPEWI ANAIDELPIF FIAAACAEGT TFVGNLSELR VKESDRLAAM AQNLQTLGVA 370 380 390 400 410 420 CDVGADFIHI YGRSDRQFLP ARVNSFGDHR IAMSLAVAGV RAAGELLIDD GAVAAVSMPQ 430 440 FRDFAAAIGM NVGEKDAKNC HD

References

[1]

"Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus." Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T., Fedorova N. , Khouri H., Bottomley S.P., Whittington R.J., Adler B., Songer J.G., Rood J.I., Paulsen I.T. Nat. Biotechnol. 25:569-575(2007) [PubMed: 17468768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCS1703A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000513 Genomic DNA. Translation: ABQ13246.1.
RefSeq	YP_001209041.1. NC_009446.1.
3D structure databases
ProteinModelPortal	A5EWS0.
ModBase	Search...
Protein-protein interaction databases
STRING	A5EWS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5122762.
GenomeReviews	Gene locus DNO_0111 in contig CP000513_GR.
KEGG	dno:DNO_0111.
PATRIC	21784512. VBIDicNod48475_0108.
TIGR	DNO_0111.
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	RIAMSFM.
Enzyme and pathway databases
BioCyc	DNOD246195:DNO_0111-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_DICNV

Accession

Primary (citable) accession number: A5EWS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program