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A5EWD6

- SYL_DICNV

UniProt

A5EWD6 - SYL_DICNV

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei634 – 6341ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDNOD246195:GHHS-246-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:DNO_0246
    OrganismiDichelobacter nodosus (strain VCS1703A)
    Taxonomic identifieri246195 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
    ProteomesiUP000000248: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Leucine--tRNA ligasePRO_1000009336Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246195.DNO_0246.

    Structurei

    3D structure databases

    ProteinModelPortaliA5EWD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi631 – 6355"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5EWD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDTYQPAQI EAAIQQQWAN EERFKAVVNP QKEKFYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPMGWD AFGMPAENAA MKNQVAPAQW 100
    TYQNIAEMKK QLQSLGFAID WSREITTCRP DYYRWEQWLF TRLYQKGVIY 150
    RKLGAVNWDP VDQTVLANEQ VIDGRGWRSG AIVEKREIPM YYFRITDYAE 200
    ELLNDLEQLD GWPERVKMMQ RNWIGKSRGM TIRFPIEPES QKGLSAENAQ 250
    FLQIYTTRPD TIFGVTFLAV AAEHPLALAA AEDNPALRQF MTECKTGSVA 300
    EADLATMPKK GMATGRFVTH PLTGKRLPVW VGNYVLSGYG DAAVMGVPAH 350
    DERDFHFAHQ YGLPIVQVIQ TEKDLPAFNA DSWQEWYGDK EEMHVIASDD 400
    CNGLNYDQAF EKLSEKLAAL NLGEPKTQYR LRDWGISRQR YWGCPIPIIH 450
    HDDGEALADT LPVVLPEDKI PDGGGSVLAQ SPDYYECRFQ GKAARRETDT 500
    MDTFVESSWY QFRYMSPHYQ KGMLDPEEVA YWQDVDQYIG GIEHAILHLL 550
    YARFFTKLLR DEGLVHTDEP FKKLLTQGMV LAGTWYREQE HGSKIWFNPA 600
    DVQVKTDDKG RIIGGVLLSD GKPVQYGGME KMSKSKNNGV DPQALIKTYG 650
    ADTARLYTMF TAPPEASLEW SESGVEGAYR FLRRLWAYCY EFRHSIAKPS 700
    EVVPLNEKHQ NIRREIHEQL RAARFDYERN QFNTVVSAGM KLFNCLNEIE 750
    PDYDALRREG VRILLLILSP IVPHITETLW QALDFSGVIS DQALPEVDET 800
    ALKQDNMTLV VQINGKRRGE ISVATDAAQQ NIIDCALADE RFAPYLAGLT 850
    VQKTIYVPKK LVNIVAK 867
    Length:867
    Mass (Da):99,087
    Last modified:June 12, 2007 - v1
    Checksum:iE394F561913ABF7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000513 Genomic DNA. Translation: ABQ13397.1.
    RefSeqiWP_012030594.1. NC_009446.1.
    YP_001209169.1. NC_009446.1.

    Genome annotation databases

    EnsemblBacteriaiABQ13397; ABQ13397; DNO_0246.
    GeneIDi5122373.
    KEGGidno:DNO_0246.
    PATRICi21784792. VBIDicNod48475_0245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000513 Genomic DNA. Translation: ABQ13397.1 .
    RefSeqi WP_012030594.1. NC_009446.1.
    YP_001209169.1. NC_009446.1.

    3D structure databases

    ProteinModelPortali A5EWD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246195.DNO_0246.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ13397 ; ABQ13397 ; DNO_0246 .
    GeneIDi 5122373.
    KEGGi dno:DNO_0246.
    PATRICi 21784792. VBIDicNod48475_0245.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DNOD246195:GHHS-246-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VCS1703A.

    Entry informationi

    Entry nameiSYL_DICNV
    AccessioniPrimary (citable) accession number: A5EWD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3