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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei634ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDNOD246195:G1G7U-245-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DNO_0246
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
Proteomesi
  • UP000000248 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093361 – 867Leucine--tRNA ligaseAdd BLAST867

Proteomic databases

PRIDEiA5EWD6

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_0246

Structurei

3D structure databases

ProteinModelPortaliA5EWD6
SMRiA5EWD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi631 – 635"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A5EWD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDTYQPAQI EAAIQQQWAN EERFKAVVNP QKEKFYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMLG KNVLQPMGWD AFGMPAENAA MKNQVAPAQW
110 120 130 140 150
TYQNIAEMKK QLQSLGFAID WSREITTCRP DYYRWEQWLF TRLYQKGVIY
160 170 180 190 200
RKLGAVNWDP VDQTVLANEQ VIDGRGWRSG AIVEKREIPM YYFRITDYAE
210 220 230 240 250
ELLNDLEQLD GWPERVKMMQ RNWIGKSRGM TIRFPIEPES QKGLSAENAQ
260 270 280 290 300
FLQIYTTRPD TIFGVTFLAV AAEHPLALAA AEDNPALRQF MTECKTGSVA
310 320 330 340 350
EADLATMPKK GMATGRFVTH PLTGKRLPVW VGNYVLSGYG DAAVMGVPAH
360 370 380 390 400
DERDFHFAHQ YGLPIVQVIQ TEKDLPAFNA DSWQEWYGDK EEMHVIASDD
410 420 430 440 450
CNGLNYDQAF EKLSEKLAAL NLGEPKTQYR LRDWGISRQR YWGCPIPIIH
460 470 480 490 500
HDDGEALADT LPVVLPEDKI PDGGGSVLAQ SPDYYECRFQ GKAARRETDT
510 520 530 540 550
MDTFVESSWY QFRYMSPHYQ KGMLDPEEVA YWQDVDQYIG GIEHAILHLL
560 570 580 590 600
YARFFTKLLR DEGLVHTDEP FKKLLTQGMV LAGTWYREQE HGSKIWFNPA
610 620 630 640 650
DVQVKTDDKG RIIGGVLLSD GKPVQYGGME KMSKSKNNGV DPQALIKTYG
660 670 680 690 700
ADTARLYTMF TAPPEASLEW SESGVEGAYR FLRRLWAYCY EFRHSIAKPS
710 720 730 740 750
EVVPLNEKHQ NIRREIHEQL RAARFDYERN QFNTVVSAGM KLFNCLNEIE
760 770 780 790 800
PDYDALRREG VRILLLILSP IVPHITETLW QALDFSGVIS DQALPEVDET
810 820 830 840 850
ALKQDNMTLV VQINGKRRGE ISVATDAAQQ NIIDCALADE RFAPYLAGLT
860
VQKTIYVPKK LVNIVAK
Length:867
Mass (Da):99,087
Last modified:June 12, 2007 - v1
Checksum:iE394F561913ABF7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000513 Genomic DNA Translation: ABQ13397.1
RefSeqiWP_012030594.1, NC_009446.1

Genome annotation databases

EnsemblBacteriaiABQ13397; ABQ13397; DNO_0246
KEGGidno:DNO_0246

Similar proteinsi

Entry informationi

Entry nameiSYL_DICNV
AccessioniPrimary (citable) accession number: A5EWD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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