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A5EWD6

- SYL_DICNV

UniProt

A5EWD6 - SYL_DICNV

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDNOD246195:GHHS-246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DNO_0246
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
ProteomesiUP000000248: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Leucine--tRNA ligasePRO_1000009336Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_0246.

Structurei

3D structure databases

ProteinModelPortaliA5EWD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi631 – 6355"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5EWD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDTYQPAQI EAAIQQQWAN EERFKAVVNP QKEKFYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMLG KNVLQPMGWD AFGMPAENAA MKNQVAPAQW
110 120 130 140 150
TYQNIAEMKK QLQSLGFAID WSREITTCRP DYYRWEQWLF TRLYQKGVIY
160 170 180 190 200
RKLGAVNWDP VDQTVLANEQ VIDGRGWRSG AIVEKREIPM YYFRITDYAE
210 220 230 240 250
ELLNDLEQLD GWPERVKMMQ RNWIGKSRGM TIRFPIEPES QKGLSAENAQ
260 270 280 290 300
FLQIYTTRPD TIFGVTFLAV AAEHPLALAA AEDNPALRQF MTECKTGSVA
310 320 330 340 350
EADLATMPKK GMATGRFVTH PLTGKRLPVW VGNYVLSGYG DAAVMGVPAH
360 370 380 390 400
DERDFHFAHQ YGLPIVQVIQ TEKDLPAFNA DSWQEWYGDK EEMHVIASDD
410 420 430 440 450
CNGLNYDQAF EKLSEKLAAL NLGEPKTQYR LRDWGISRQR YWGCPIPIIH
460 470 480 490 500
HDDGEALADT LPVVLPEDKI PDGGGSVLAQ SPDYYECRFQ GKAARRETDT
510 520 530 540 550
MDTFVESSWY QFRYMSPHYQ KGMLDPEEVA YWQDVDQYIG GIEHAILHLL
560 570 580 590 600
YARFFTKLLR DEGLVHTDEP FKKLLTQGMV LAGTWYREQE HGSKIWFNPA
610 620 630 640 650
DVQVKTDDKG RIIGGVLLSD GKPVQYGGME KMSKSKNNGV DPQALIKTYG
660 670 680 690 700
ADTARLYTMF TAPPEASLEW SESGVEGAYR FLRRLWAYCY EFRHSIAKPS
710 720 730 740 750
EVVPLNEKHQ NIRREIHEQL RAARFDYERN QFNTVVSAGM KLFNCLNEIE
760 770 780 790 800
PDYDALRREG VRILLLILSP IVPHITETLW QALDFSGVIS DQALPEVDET
810 820 830 840 850
ALKQDNMTLV VQINGKRRGE ISVATDAAQQ NIIDCALADE RFAPYLAGLT
860
VQKTIYVPKK LVNIVAK
Length:867
Mass (Da):99,087
Last modified:June 12, 2007 - v1
Checksum:iE394F561913ABF7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000513 Genomic DNA. Translation: ABQ13397.1.
RefSeqiYP_001209169.1. NC_009446.1.

Genome annotation databases

EnsemblBacteriaiABQ13397; ABQ13397; DNO_0246.
GeneIDi5122373.
KEGGidno:DNO_0246.
PATRICi21784792. VBIDicNod48475_0245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000513 Genomic DNA. Translation: ABQ13397.1 .
RefSeqi YP_001209169.1. NC_009446.1.

3D structure databases

ProteinModelPortali A5EWD6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246195.DNO_0246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ13397 ; ABQ13397 ; DNO_0246 .
GeneIDi 5122373.
KEGGi dno:DNO_0246.
PATRICi 21784792. VBIDicNod48475_0245.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DNOD246195:GHHS-246-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCS1703A.

Entry informationi

Entry nameiSYL_DICNV
AccessioniPrimary (citable) accession number: A5EWD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3