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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDNOD246195:G1G7U-288-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:DNO_0291
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
Proteomesi
  • UP000000248 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei189 – 209HelicalUniRule annotationAdd BLAST21
Transmembranei220 – 240HelicalUniRule annotationAdd BLAST21
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030261 – 267Undecaprenyl-diphosphataseAdd BLAST267

Proteomic databases

PRIDEiA5EW93

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_0291

Structurei

3D structure databases

SMRiA5EW93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A5EW93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLWQAFILS LIQGITEFLP ISSSGHLVIT RELLHWQDAG VAFDAFTGLG
60 70 80 90 100
TLTAVLFYYR KDVCSILYHW FRQFRHCDAP PAPEAKLGNQ LIVATLPALL
110 120 130 140 150
IGFMVKDHID ALTHRPLLIA STTMIFAIFL AAADFWGRKK LSLPETNYRQ
160 170 180 190 200
AFYYGLAQTL ALVPGVSRSG ITLTAGLAMH FSRESAARFS FLQSIPISAA
210 220 230 240 250
AGGYGLWKLA TNPSDFSWQL IALSYVTATL AAYVCIALFI RFLNTVGMMP
260
HVIYRLLLGA YLFFVFM
Length:267
Mass (Da):29,701
Last modified:June 12, 2007 - v1
Checksum:i9075AE9E62CF0A3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000513 Genomic DNA Translation: ABQ13612.1
RefSeqiWP_012030635.1, NC_009446.1

Genome annotation databases

EnsemblBacteriaiABQ13612; ABQ13612; DNO_0291
KEGGidno:DNO_0291

Entry informationi

Entry nameiUPPP_DICNV
AccessioniPrimary (citable) accession number: A5EW93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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