A5EVP6 (PYRB_DICNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	DNO_0490

Organism

Dichelobacter nodosus (strain VCS1703A) [Complete proteome] [HAMAP]

Taxonomic identifier

246195 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Cardiobacteriales › Cardiobacteriaceae › Dichelobacter

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321099

Sequences

	Sequence		Length	Mass (Da)
	A5EVP6 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 581FE9836DF009C4	FASTA	348	38,764
	10 20 30 40 50 60 MSLVGCHILS IDHFSRQDLE ELLMTAKLLE PVAQRKVRCN VLDGSVMANL FFEASTRTRM 70 80 90 100 110 120 SFHTAFARLG GSVVDTTGFT FSSISKGESL SDTARVIAGY ADVIVMRHPD QGSVAEFASK 130 140 150 160 170 180 INVPVINAGD GIGEHPSQAL LDYYTINNEF ERLKKNIDGM TIAMVGDLKN GRTIHSLAKL 190 200 210 220 230 240 LSLFDNIHFR FIAPETLRAP AELLELLRSR GHDVQEFDDI ANGLPGTDII YATRIQRERI 250 260 270 280 290 300 KDGELMEGYS EKFRINAAAV ARYATPETII MHPLPRDSRA GAFDLSTDLD NHPQLAIFRQ 310 320 330 340 ADNGVTVRMA IFAMVLNVHR GIESFFSPHR GFRPDRYGQG DADFYQLK

References

[1]

"Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus." Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T., Fedorova N. , Khouri H., Bottomley S.P., Whittington R.J., Adler B., Songer J.G., Rood J.I., Paulsen I.T. Nat. Biotechnol. 25:569-575(2007) [PubMed: 17468768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCS1703A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000513 Genomic DNA. Translation: ABQ14273.1.
RefSeq	YP_001209402.1. NC_009446.1.
3D structure databases
ProteinModelPortal	A5EVP6.
ModBase	Search...
Protein-protein interaction databases
STRING	A5EVP6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5122760.
GenomeReviews	Gene locus DNO_0490 in contig CP000513_GR.
KEGG	dno:DNO_0490.
PATRIC	21785286. VBIDicNod48475_0487.
TIGR	DNO_0490.
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	ADRYENT.
Enzyme and pathway databases
BioCyc	DNOD246195:DNO_0490-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_DICNV

Accession

Primary (citable) accession number: A5EVP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program