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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi934ZincUniRule annotation1
Metal bindingi936ZincUniRule annotation1
Metal bindingi945ZincUniRule annotation1
Metal bindingi946ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:BBta_7588
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000000246 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003207451 – 950Protein translocase subunit SecAAdd BLAST950

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi288000.BBta_7588.

Structurei

3D structure databases

ProteinModelPortaliA5ETE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5ETE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGALARKLF GSANDRRVKG YQARVNAINA LEPELAKLTD EQLKARTAEF
60 70 80 90 100
KAQLAEGKTL DDILVPAFAT VREASKRTLG QRHFDVQLIG GMVLHEGDIA
110 120 130 140 150
EMKTGEGKTL VATLAVYLNA LAGKGVHVVT VNDYLARRDA GWMSQIYGFL
160 170 180 190 200
GLTTGVIVHG LDDAERKLAY ACDITYGTNN EYGFDYLRDN MKYRLEDMVQ
210 220 230 240 250
RGHYFAIVDE VDSILIDEAR TPLIISGPLD DRSDFYNTID TFVPKLDKSD
260 270 280 290 300
YDVDEKQRTV TLTEAGMEKI ETLLRDAGQL KGESLYDVEN VSVVHHINQA
310 320 330 340 350
LRAHTLFTRD KDYIVRDGEV VIIDEFTGRM MPGRRYSEGL HQALEAKEHV
360 370 380 390 400
QVQPENQTLA SITFQNYFRM YEKLAGMTGT AATEADELFD IYKLEVVEIP
410 420 430 440 450
TNLPVARLDE DDEVYRTQQE KYAAILAEIE RANSRLQPVL VGTASIEKSE
460 470 480 490 500
VLAAYLKQHG YKQIDFGSER ALDKLYAAAR AGKPAKLFAV LNARFHEQEA
510 520 530 540 550
YIVAEAGVPG AITIATNMAG RGTDIKLGGS LEMRIQQETA GITDETEKAA
560 570 580 590 600
KIEQIKADIA RFREIVLKAE ETVEIEPAKG SKPAKTVVKP GGLYIIGSER
610 620 630 640 650
HESRRIDNQL RGRSGRQGDP GRSKFFLSLE DDLMRIFGSD RLDSMLTRLG
660 670 680 690 700
LKEGEAIIHP WINKALEKAQ QKVEARNFDI RKNLLKFDNV QNDQRKVIFD
710 720 730 740 750
QRVELMQDES VAETIADMRH AFIDDLVSKH VPEHAYAEQW DVAGLKEELK
760 770 780 790 800
RVLDIELPVD EWAKEEGIAD EELLKRIETH ADERMAAKVG QWGPDVMRYV
810 820 830 840 850
EKTILLQTLD HLWREHLVML DHLRQVIGLR GYGQRDPLQE YKSEAFTLFE
860 870 880 890 900
AMIAHLREAV TAQLMRVEIV PPEEQQPVLP PMQAHHANPT TGEDEMAFAN
910 920 930 940 950
VSLVPSSGAA PVPAEARNPN DPSTWGKVGR NEDCPCGSGK KYKHCHGRYA
Length:950
Mass (Da):106,709
Last modified:June 12, 2007 - v1
Checksum:iBAAC575B37441A00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000494 Genomic DNA. Translation: ABQ39435.1.
RefSeqiWP_012047326.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ39435; ABQ39435; BBta_7588.
KEGGibbt:BBta_7588.
PATRICi21215783. VBIBraSp29847_7539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000494 Genomic DNA. Translation: ABQ39435.1.
RefSeqiWP_012047326.1. NC_009485.1.

3D structure databases

ProteinModelPortaliA5ETE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288000.BBta_7588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ39435; ABQ39435; BBta_7588.
KEGGibbt:BBta_7588.
PATRICi21215783. VBIBraSp29847_7539.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_BRASB
AccessioniPrimary (citable) accession number: A5ETE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.