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A5EST0 (PYRE_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:BBta_7360
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_1000066211

Regions

Region128 – 13695-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9915-phosphoribose 1-diphosphate By similarity
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1321Orotate By similarity
Binding site1601Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
A5EST0 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 1B1AED36EC7213AB

FASTA18520,072
        10         20         30         40         50         60 
MSKSASRARL LEIIRRRSFG RGEVTLASGR KSDFYFNLKP TMMDPEGATL LAELTYEALK 

        70         80         90        100        110        120 
DEGFDYIGGL EMGAVPLAGA IAQISWIKGH PIAAFFVRKK PKEHGAKLAI EGLTRDETLA 

       130        140        150        160        170        180 
GKRIVVVEDV TTTGGSAMKA VETLREAGAN VSLVFTMVDR EEGAAETFAA AGLPFRALYK 


AREFL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ39224.1.
RefSeqYP_001243130.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5EST0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5EST0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5149832.
GenomeReviewsGene locus BBta_7360 in contig CP000494_GR.
KEGGbbt:BBta_7360.
PATRIC21215347. VBIBraSp29847_7322.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMAGKEADYY.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BRASB
AccessionPrimary (citable) accession number: A5EST0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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