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A5ESQ5 (TRUA_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA pseudouridine synthase A

EC=5.4.99.12
Alternative name(s):
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
Gene names
Name:truA
Ordered Locus Names:BBta_7335
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity. HAMAP-Rule MF_00171

Catalytic activity

tRNA uridine(38-40) = tRNA pseudouridine(38-40). HAMAP-Rule MF_00171

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00171

Sequence similarities

Belongs to the tRNA pseudouridine synthase TruA family.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245tRNA pseudouridine synthase A HAMAP-Rule MF_00171
PRO_1000017045

Sites

Active site521Nucleophile By similarity
Binding site1111Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A5ESQ5 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 514623A7F177EC83

FASTA24527,106
        10         20         30         40         50         60 
MPRYKLTIEY DGTPFCGWQL QETLPSVQGA LEAAVQATCG VPTRVHGSGR TDAGVHATGQ 

        70         80         90        100        110        120 
VAHCDIAKDF RPDKLRDALN AHLRPNPVAV LEAEIVSDTF EARFSARKRH YRYRIVNRRS 

       130        140        150        160        170        180 
NLALEVGRVW RVPQRLDSDA MHAAAQRLIG RHDFTTFRDT ECQAKSPEKT LDQLDVVRDG 

       190        200        210        220        230        240 
DAVTILTSAR SYLHSQVRSM VGSLVWVGQG RWSADDLAAA LAARNRAACG VVAPPEGLYL 


VKVDY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000494 Genomic DNA. Translation: ABQ39199.1.
RefSeqYP_001243105.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5ESQ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288000.BBta_7335.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ39199; ABQ39199; BBta_7335.
GeneID5149518.
KEGGbbt:BBta_7335.
PATRIC21215295. VBIBraSp29847_7296.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0101.
HOGENOMHOG000248672.
KOK06173.
OMAYLTKVEY.
OrthoDBEOG6Z9B4R.

Enzyme and pathway databases

BioCycBSP288000:GJBR-7039-MONOMER.

Family and domain databases

Gene3D3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPMF_00171. TruA.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERPTHR11142. PTHR11142. 1 hit.
PfamPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00071. hisT_truA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRUA_BRASB
AccessionPrimary (citable) accession number: A5ESQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families