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A5ESQ2 (DAPD_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Short name=Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:BBta_7332
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2812812,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
PRO_1000047120

Sites

Binding site1081Substrate By similarity
Binding site1451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A5ESQ2 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: EE8F4B53BAC8E440

FASTA28129,880
        10         20         30         40         50         60 
MSLSALESTI NSAFDARDGV STTTKGEIRD AVESALELLD KGEARVAERG TDGTWSVNQW 

        70         80         90        100        110        120 
LKKAVLLSFR LNDMSVIPGG PGQASWWDKV PSKFEGWGEN RFREAGFRAV PGAIVRRSAF 

       130        140        150        160        170        180 
IAKNVVLMPS FVNLGAYVDE ATMVDTWSTV GSCAQIGKRV HISGGVGIGG VLEPLQAGPV 

       190        200        210        220        230        240 
IIEDDCFIGA RSEVAEGVVV RKGAVLAMGV FLGASTKVID RETGETFVGE VPEYAVVVPG 

       250        260        270        280 
ALPGKPMKNG QIGPSTACAV IVKRVDERTR SKTSINELLR D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000494 Genomic DNA. Translation: ABQ39196.1.
RefSeqYP_001243102.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5ESQ2.
SMRA5ESQ2. Positions 3-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288000.BBta_7332.

Proteomic databases

PRIDEA5ESQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ39196; ABQ39196; BBta_7332.
GeneID5149515.
KEGGbbt:BBta_7332.
PATRIC21215289. VBIBraSp29847_7293.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2171.
HOGENOMHOG000003295.
KOK00674.
OMAYIARNTV.
OrthoDBEOG68H8BV.

Enzyme and pathway databases

BioCycBSP288000:GJBR-7036-MONOMER.
UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPD_BRASB
AccessionPrimary (citable) accession number: A5ESQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways