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A5ESQ2

- DAPD_BRASB

UniProt

A5ESQ2 - DAPD_BRASB

Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei108 – 1081SubstrateUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation

    GO - Molecular functioni

    1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciBSP288000:GJBR-7036-MONOMER.
    UniPathwayiUPA00034; UER00019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
    Alternative name(s):
    Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
    Short name:
    THDP succinyltransferaseUniRule annotation
    Short name:
    THP succinyltransferaseUniRule annotation
    Short name:
    Tetrahydropicolinate succinylaseUniRule annotation
    Gene namesi
    Name:dapDUniRule annotation
    Ordered Locus Names:BBta_7332
    OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
    Taxonomic identifieri288000 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000000246: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2812812,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_1000047120Add
    BLAST

    Proteomic databases

    PRIDEiA5ESQ2.

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi288000.BBta_7332.

    Structurei

    3D structure databases

    ProteinModelPortaliA5ESQ2.
    SMRiA5ESQ2. Positions 3-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2171.
    HOGENOMiHOG000003295.
    KOiK00674.
    OMAiYIARNTV.
    OrthoDBiEOG68H8BV.

    Family and domain databases

    Gene3Di1.10.166.10. 1 hit.
    HAMAPiMF_00811. DapD.
    InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
    PfamiPF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR00965. dapD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5ESQ2-1 [UniParc]FASTAAdd to Basket

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    MSLSALESTI NSAFDARDGV STTTKGEIRD AVESALELLD KGEARVAERG    50
    TDGTWSVNQW LKKAVLLSFR LNDMSVIPGG PGQASWWDKV PSKFEGWGEN 100
    RFREAGFRAV PGAIVRRSAF IAKNVVLMPS FVNLGAYVDE ATMVDTWSTV 150
    GSCAQIGKRV HISGGVGIGG VLEPLQAGPV IIEDDCFIGA RSEVAEGVVV 200
    RKGAVLAMGV FLGASTKVID RETGETFVGE VPEYAVVVPG ALPGKPMKNG 250
    QIGPSTACAV IVKRVDERTR SKTSINELLR D 281
    Length:281
    Mass (Da):29,880
    Last modified:June 12, 2007 - v1
    Checksum:iEE8F4B53BAC8E440
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000494 Genomic DNA. Translation: ABQ39196.1.
    RefSeqiWP_012047099.1. NC_009485.1.
    YP_001243102.1. NC_009485.1.

    Genome annotation databases

    EnsemblBacteriaiABQ39196; ABQ39196; BBta_7332.
    GeneIDi5149515.
    KEGGibbt:BBta_7332.
    PATRICi21215289. VBIBraSp29847_7293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000494 Genomic DNA. Translation: ABQ39196.1 .
    RefSeqi WP_012047099.1. NC_009485.1.
    YP_001243102.1. NC_009485.1.

    3D structure databases

    ProteinModelPortali A5ESQ2.
    SMRi A5ESQ2. Positions 3-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288000.BBta_7332.

    Proteomic databases

    PRIDEi A5ESQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ39196 ; ABQ39196 ; BBta_7332 .
    GeneIDi 5149515.
    KEGGi bbt:BBta_7332.
    PATRICi 21215289. VBIBraSp29847_7293.

    Phylogenomic databases

    eggNOGi COG2171.
    HOGENOMi HOG000003295.
    KOi K00674.
    OMAi YIARNTV.
    OrthoDBi EOG68H8BV.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00019 .
    BioCyci BSP288000:GJBR-7036-MONOMER.

    Family and domain databases

    Gene3Di 1.10.166.10. 1 hit.
    HAMAPi MF_00811. DapD.
    InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
    Pfami PF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR00965. dapD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BTAi1 / ATCC BAA-1182.

    Entry informationi

    Entry nameiDAPD_BRASB
    AccessioniPrimary (citable) accession number: A5ESQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3