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A5EQ73 (ACSF_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
Short name=Aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase
EC=1.14.13.81
Gene names
Name:acsF
Ordered Locus Names:BBta_6407
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840

Catalytic activity

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Cofactor

Iron By similarity. HAMAP MF_01840

Pathway

Porphyrin biosynthesis; bacteriochlorophyll biosynthesis (light-independent). HAMAP MF_01840

Sequence similarities

Belongs to the AcsF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
PRO_1000070543

Sequences

Sequence LengthMass (Da)Tools
A5EQ73 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: EFDCC63CEEA9326B

FASTA35341,246
        10         20         30         40         50         60 
MIAMEGGAGN ISTKMALEDT ILTPRFYTTD FAAMDRLNVD LVRREWDAVM AELRADHNRK 

        70         80         90        100        110        120 
HFVRTPEFEK DLNELPEALR LEFKDFLVSS LTAEFSGCVL YAEIKKRITN PDIRELFSYM 

       130        140        150        160        170        180 
SRDEARHAGF INEILKDHGI GVDLGFLTKV KKYTYFKPKF IFYATYLSEK IGYARYITIY 

       190        200        210        220        230        240 
RQMERHPERQ FHPIFKWFER WCNDEFRHGE AFALLMRADP KLLSGLNKLW IKFFLLAVFA 

       250        260        270        280        290        300 
TMHVRDHMRP AFYEALGMPV DEYDMRVFRI TSEISRQVFP VMLDIDNPRF WAGLNQLRKV 

       310        320        330        340        350 
SEAIADAKAQ GGVMGAIKRA VLPLKAALTF GRLYMLPAKS NELPREIRLQ PAW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ38317.1.
RefSeqYP_001242223.1. NC_009485.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA5EQ73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5154687.
GenomeReviewsGene locus BBta_6407 in contig CP000494_GR.
KEGGbbt:BBta_6407.
PATRIC21213497. VBIBraSp29847_6402.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHBG284843.
OMAHGDFFDA.
ProtClustDBPRK13654.

Family and domain databases

HAMAPMF_01840. AcsF.
[Tree]
InterProIPR008434. AcsF.
IPR012347. Ferritin-rel.
IPR009078. Ferritin/RR-like.
IPR003251. Rubrerythrin.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KOK04035.
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACSF_BRASB
AccessionPrimary (citable) accession number: A5EQ73
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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