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A5EPK0 (MURB_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase
EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:BBta_6170
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_1000002864

Regions

Domain34 – 199166FAD-binding PCMH-type

Sites

Active site1791 By similarity
Active site2281Proton donor By similarity
Active site2981 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5EPK0 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 556443BBE09A6478

FASTA30732,467
        10         20         30         40         50         60 
MSFADITPDL KAAMPELRGR LLANEGLAPL TWFRVGGPAQ VLFTPADADD LAYFLKHLPA 

        70         80         90        100        110        120 
ELPVYVIGVG SNLIVRDGGV PGVVIRLAPR AFGEVKVDGD IVAAGTAALD KRVAEVAASA 

       130        140        150        160        170        180 
NLTGLEFLFG IPGTIGGALR MNAGANGGET KDILVEATAI DRQGVTHHFT NADMNFTYRA 

       190        200        210        220        230        240 
SGADPSLIFT AARFRGKPSD AEAIRGRMAE VQAHRETAQP IREKTGGSTF KNPPGHSAWR 

       250        260        270        280        290        300 
LVDAAGCRGL KVGGAQVSEM HCNFLINTGN ATADDIETLG ETVRERVEAT SGIALQWEIK 


RIGLKAR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ38094.1.
RefSeqYP_001242000.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5EPK0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5EPK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5152034.
GenomeReviewsGene locus BBta_6170 in contig CP000494_GR.
KEGGbbt:BBta_6170.
PATRIC21213021. VBIBraSp29847_6165.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHBG686573.
OMASKKHAGF.
ProtClustDBPRK13905.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_BRASB
AccessionPrimary (citable) accession number: A5EPK0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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