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A5ENA7 (SAHH_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Ordered Locus Names:BBta_5698
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Adenosylhomocysteinase HAMAP MF_00563
PRO_1000024710

Regions

Nucleotide binding198 – 2003NAD By similarity
Nucleotide binding261 – 2666NAD By similarity
Nucleotide binding340 – 3423NAD By similarity

Sites

Binding site601Substrate By similarity
Binding site1351Substrate By similarity
Binding site1971Substrate By similarity
Binding site2271Substrate By similarity
Binding site2311Substrate By similarity
Binding site2321NAD By similarity
Binding site2841NAD By similarity
Binding site3191NAD By similarity
Binding site3851NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5ENA7 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 17DACFD90AEC2D44

FASTA47351,751
        10         20         30         40         50         60 
MTAKPGFNDY IVKDISLAEF GRKEISLAET EMPGLMATRE EYGPKQPLKG ARIAGSLHMT 

        70         80         90        100        110        120 
IQTAVLIETL AALGADIRWV SCNIYSTQDH AAAAIAAAGI PVFAVKGETL ADYWDYTAKL 

       130        140        150        160        170        180 
FDWHGGGHPN MILDDGGDAT MYVHLGLRAE NGDTAFLDKP ASEEEEVFFA LLKKQLKEKP 

       190        200        210        220        230        240 
KGYFAAIAAS IKGVSEETTT GVHRLYDMQK AGTLLWPAIN VNDSVTKSKF DNLYGCRESL 

       250        260        270        280        290        300 
VDGIRRGTDV MMSGKVAMVA GFGDVGKGSA ASLRQAGCRV LVSEIDPICA LQAAMEGYEV 

       310        320        330        340        350        360 
VTMEDAAPRA DIFVTATGNK DIITIEHMRA MKDRAIVCNI GHFDNEIQVA SLKNLKWTNI 

       370        380        390        400        410        420 
KPQVDEITFP DGKRMILLSE GRLVNLGNAM GHPSFVMSAS FTNQTLAQIE LYANNKDGKY 

       430        440        450        460        470 
KKEVYVLPKS LDEKVARLHL AKIGVKLTEL RPDQAAYIGV KQEGPFKSDH YRY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ37651.1.
RefSeqYP_001241557.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5ENA7.
SMRA5ENA7. Positions 9-473.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5ENA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5149355.
GenomeReviewsGene locus BBta_5698 in contig CP000494_GR.
KEGGbbt:BBta_5698.
PATRIC21212083. VBIBraSp29847_5697.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0499.
HOGENOMHBG352029.
OMASAQVWVT.
ProtClustDBPRK05476.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_BRASB
AccessionPrimary (citable) accession number: A5ENA7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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