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A5EMM2

- GCSP_BRASB

UniProt

A5EMM2 - GCSP_BRASB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, BBta_5451
Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSP288000:GJBR-5211-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BBta_5451
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000000246: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000062072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA5EMM2.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi288000.BBta_5451.

Structurei

3D structure databases

ProteinModelPortaliA5EMM2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5EMM2-1 [UniParc]FASTAAdd to Basket

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MTTPLKPLDD AATSFARRHI GPSPRDVAAM LETVGAKSVA ELMAQTLPGT    50
IRQATPLTLE PALSEVEAIG HMRALAAQNQ VFTSLIGQGY SGTIMPAVIQ 100
RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
EGTAAAEAMA LAERSARAKT KAFFVDRNVH PQTLAVLRTR AEPLGWQLIV 200
GDPVKDLDGA EVFGGLLQYP ETTGALRDPR ADIAKLHDKG ALAILAADLL 250
ALTVIASPGE LGADIAIGSA QRFGVPMGYG GPHAAYMAVR DALKRSLPGR 300
IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVIAAMYAV 350
YHGPDGLKSI ARTVHRRAAV LAAGLRKLGF APASDSFFDT VLVEAGANCD 400
EIIARAESQR INLGRDGSRL RIALDETTTA DVVEAVWRAF GGELSYAAIE 450
AEARDAVPAE LKRQRPFLTH PVFHAHRSET EMLRYLRKLA DRDLALDRAM 500
IPLGSCTMKL NATTEMIPLT WPEFSSLHPF VPRAQAAGYH TMFADLQDWL 550
CRISGYDAVS LQPNSGAQGE YAGLLAIRGY HAARGEGHRT ICLIPSSAHG 600
TNPASAHMVG MEVVVVGCDS NGNVDLADLK AKAELHSAKL AAIMITYPST 650
HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLSRPGD YGADVSHFNL 700
HKTFCIPHGG GGPGMGPIGV KAHLAPFLPG HPATDAATPS PVGPVSAAPY 750
GSASILTISY IYMLLMGGEG LTRATEIAIL NANYVAARLD PHFPVLYRNE 800
RGRVAHECII DPRPLKQTCG VTVDDIAKRL IDYGFHAPTM SFPVAGTLMI 850
EPTESESKAE LDRFCDAMIA IRKEIAAVEQ GRFTIEASPL RHAPHTVHDI 900
ADDDWNRVYR RSEGCFPEGT SRTDKYWCPV GRVDNVYGDR NLVCSCPPIG 950
DYAQAAE 957
Length:957
Mass (Da):102,983
Last modified:June 12, 2007 - v1
Checksum:iCCCF1AE158731F2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ37416.1.
RefSeqiWP_012045378.1. NC_009485.1.
YP_001241322.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ37416; ABQ37416; BBta_5451.
GeneIDi5149911.
KEGGibbt:BBta_5451.
PATRICi21211591. VBIBraSp29847_5451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ37416.1 .
RefSeqi WP_012045378.1. NC_009485.1.
YP_001241322.1. NC_009485.1.

3D structure databases

ProteinModelPortali A5EMM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288000.BBta_5451.

Proteomic databases

PRIDEi A5EMM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ37416 ; ABQ37416 ; BBta_5451 .
GeneIDi 5149911.
KEGGi bbt:BBta_5451.
PATRICi 21211591. VBIBraSp29847_5451.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BSP288000:GJBR-5211-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BTAi1 / ATCC BAA-1182.

Entry informationi

Entry nameiGCSP_BRASB
AccessioniPrimary (citable) accession number: A5EMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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