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A5EMM2

- GCSP_BRASB

UniProt

A5EMM2 - GCSP_BRASB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSP288000:GJBR-5211-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:BBta_5451
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000000246: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000062072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiA5EMM2.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi288000.BBta_5451.

Structurei

3D structure databases

ProteinModelPortaliA5EMM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5EMM2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPLKPLDD AATSFARRHI GPSPRDVAAM LETVGAKSVA ELMAQTLPGT
60 70 80 90 100
IRQATPLTLE PALSEVEAIG HMRALAAQNQ VFTSLIGQGY SGTIMPAVIQ
110 120 130 140 150
RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD
160 170 180 190 200
EGTAAAEAMA LAERSARAKT KAFFVDRNVH PQTLAVLRTR AEPLGWQLIV
210 220 230 240 250
GDPVKDLDGA EVFGGLLQYP ETTGALRDPR ADIAKLHDKG ALAILAADLL
260 270 280 290 300
ALTVIASPGE LGADIAIGSA QRFGVPMGYG GPHAAYMAVR DALKRSLPGR
310 320 330 340 350
IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVIAAMYAV
360 370 380 390 400
YHGPDGLKSI ARTVHRRAAV LAAGLRKLGF APASDSFFDT VLVEAGANCD
410 420 430 440 450
EIIARAESQR INLGRDGSRL RIALDETTTA DVVEAVWRAF GGELSYAAIE
460 470 480 490 500
AEARDAVPAE LKRQRPFLTH PVFHAHRSET EMLRYLRKLA DRDLALDRAM
510 520 530 540 550
IPLGSCTMKL NATTEMIPLT WPEFSSLHPF VPRAQAAGYH TMFADLQDWL
560 570 580 590 600
CRISGYDAVS LQPNSGAQGE YAGLLAIRGY HAARGEGHRT ICLIPSSAHG
610 620 630 640 650
TNPASAHMVG MEVVVVGCDS NGNVDLADLK AKAELHSAKL AAIMITYPST
660 670 680 690 700
HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLSRPGD YGADVSHFNL
710 720 730 740 750
HKTFCIPHGG GGPGMGPIGV KAHLAPFLPG HPATDAATPS PVGPVSAAPY
760 770 780 790 800
GSASILTISY IYMLLMGGEG LTRATEIAIL NANYVAARLD PHFPVLYRNE
810 820 830 840 850
RGRVAHECII DPRPLKQTCG VTVDDIAKRL IDYGFHAPTM SFPVAGTLMI
860 870 880 890 900
EPTESESKAE LDRFCDAMIA IRKEIAAVEQ GRFTIEASPL RHAPHTVHDI
910 920 930 940 950
ADDDWNRVYR RSEGCFPEGT SRTDKYWCPV GRVDNVYGDR NLVCSCPPIG

DYAQAAE
Length:957
Mass (Da):102,983
Last modified:June 12, 2007 - v1
Checksum:iCCCF1AE158731F2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000494 Genomic DNA. Translation: ABQ37416.1.
RefSeqiWP_012045378.1. NC_009485.1.
YP_001241322.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ37416; ABQ37416; BBta_5451.
GeneIDi5149911.
KEGGibbt:BBta_5451.
PATRICi21211591. VBIBraSp29847_5451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000494 Genomic DNA. Translation: ABQ37416.1 .
RefSeqi WP_012045378.1. NC_009485.1.
YP_001241322.1. NC_009485.1.

3D structure databases

ProteinModelPortali A5EMM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288000.BBta_5451.

Proteomic databases

PRIDEi A5EMM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ37416 ; ABQ37416 ; BBta_5451 .
GeneIDi 5149911.
KEGGi bbt:BBta_5451.
PATRICi 21211591. VBIBraSp29847_5451.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BSP288000:GJBR-5211-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BTAi1 / ATCC BAA-1182.

Entry informationi

Entry nameiGCSP_BRASB
AccessioniPrimary (citable) accession number: A5EMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3