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A5EMM2

- GCSP_BRASB

UniProt

A5EMM2 - GCSP_BRASB

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBSP288000:GJBR-5211-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BBta_5451
    OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
    Taxonomic identifieri288000 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000000246: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000062072Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA5EMM2.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi288000.BBta_5451.

    Structurei

    3D structure databases

    ProteinModelPortaliA5EMM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5EMM2-1 [UniParc]FASTAAdd to Basket

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    MTTPLKPLDD AATSFARRHI GPSPRDVAAM LETVGAKSVA ELMAQTLPGT    50
    IRQATPLTLE PALSEVEAIG HMRALAAQNQ VFTSLIGQGY SGTIMPAVIQ 100
    RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
    EGTAAAEAMA LAERSARAKT KAFFVDRNVH PQTLAVLRTR AEPLGWQLIV 200
    GDPVKDLDGA EVFGGLLQYP ETTGALRDPR ADIAKLHDKG ALAILAADLL 250
    ALTVIASPGE LGADIAIGSA QRFGVPMGYG GPHAAYMAVR DALKRSLPGR 300
    IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVIAAMYAV 350
    YHGPDGLKSI ARTVHRRAAV LAAGLRKLGF APASDSFFDT VLVEAGANCD 400
    EIIARAESQR INLGRDGSRL RIALDETTTA DVVEAVWRAF GGELSYAAIE 450
    AEARDAVPAE LKRQRPFLTH PVFHAHRSET EMLRYLRKLA DRDLALDRAM 500
    IPLGSCTMKL NATTEMIPLT WPEFSSLHPF VPRAQAAGYH TMFADLQDWL 550
    CRISGYDAVS LQPNSGAQGE YAGLLAIRGY HAARGEGHRT ICLIPSSAHG 600
    TNPASAHMVG MEVVVVGCDS NGNVDLADLK AKAELHSAKL AAIMITYPST 650
    HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLSRPGD YGADVSHFNL 700
    HKTFCIPHGG GGPGMGPIGV KAHLAPFLPG HPATDAATPS PVGPVSAAPY 750
    GSASILTISY IYMLLMGGEG LTRATEIAIL NANYVAARLD PHFPVLYRNE 800
    RGRVAHECII DPRPLKQTCG VTVDDIAKRL IDYGFHAPTM SFPVAGTLMI 850
    EPTESESKAE LDRFCDAMIA IRKEIAAVEQ GRFTIEASPL RHAPHTVHDI 900
    ADDDWNRVYR RSEGCFPEGT SRTDKYWCPV GRVDNVYGDR NLVCSCPPIG 950
    DYAQAAE 957
    Length:957
    Mass (Da):102,983
    Last modified:June 12, 2007 - v1
    Checksum:iCCCF1AE158731F2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000494 Genomic DNA. Translation: ABQ37416.1.
    RefSeqiWP_012045378.1. NC_009485.1.
    YP_001241322.1. NC_009485.1.

    Genome annotation databases

    EnsemblBacteriaiABQ37416; ABQ37416; BBta_5451.
    GeneIDi5149911.
    KEGGibbt:BBta_5451.
    PATRICi21211591. VBIBraSp29847_5451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000494 Genomic DNA. Translation: ABQ37416.1 .
    RefSeqi WP_012045378.1. NC_009485.1.
    YP_001241322.1. NC_009485.1.

    3D structure databases

    ProteinModelPortali A5EMM2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288000.BBta_5451.

    Proteomic databases

    PRIDEi A5EMM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ37416 ; ABQ37416 ; BBta_5451 .
    GeneIDi 5149911.
    KEGGi bbt:BBta_5451.
    PATRICi 21211591. VBIBraSp29847_5451.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BSP288000:GJBR-5211-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BTAi1 / ATCC BAA-1182.

    Entry informationi

    Entry nameiGCSP_BRASB
    AccessioniPrimary (citable) accession number: A5EMM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3