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A5EKH9 (A5EKH9_BRASB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase 2 HAMAP MF_00178
Short name=DMRL synthase 2 HAMAP MF_00178
Short name=Lumazine synthase 2 HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178
Alternative name(s):
Riboflavin synthase beta chain 2 HAMAP MF_00178
Gene names
Name:ribH EMBL ABQ36673.1
Synonyms:ribH2 HAMAP MF_00178
Ordered Locus Names:BBta_4645
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP] EMBL ABQ36673.1
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178

Sequence similarities

Belongs to the DMRL synthase family. HAMAP MF_00178

Ontologies

Keywords
   Biological processRiboflavin biosynthesis HAMAP MF_00178
   Molecular functionTransferase HAMAP MF_00178 EMBL ABQ36673.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processriboflavin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentriboflavin synthase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionriboflavin synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A5EKH9 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 01904CC5CD39D4FA

FASTA16317,298
        10         20         30         40         50         60 
MADARRAPLK DQTDITGARA LIVEARFYDD IQDAMLEGAT AELKAAGVGY DVLTVTGSLE 

        70         80         90        100        110        120 
IPATIAIALD AATQHGKPYD LAIALGCVIR GDTIHFEIVS QESSRALMDL SVARGLPLGN 

       130        140        150        160 
GILTVNNEDQ AWARARVSEM NKGGDAARAA LAVLRIKRRL ARG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ36673.1.
RefSeqYP_001240579.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5EKH9.
SMRA5EKH9. Positions 21-161.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5EKH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5149075.
GenomeReviewsGene locus BBta_4645 in contig CP000494_GR.
KEGGbbt:BBta_4645.
PATRIC21210049. VBIBraSp29847_4688.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0054.
HOGENOMHBG311126.
OMASSRALMD.
ProtClustDBPRK00061.

Family and domain databases

HAMAPMF_00178. Lumazine_synth.
[Tree]
InterProIPR002180. DMRL_synthase.
[Graphical view]
Gene3DG3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KOK00794.
PANTHERPTHR21058. DMRL_synthase. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. Lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5EKH9_BRASB
AccessionPrimary (citable) accession number: A5EKH9
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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