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A5EIB4

- AMPA_BRASB

UniProt

A5EIB4 - AMPA_BRASB

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Protein
Probable cytosol aminopeptidase
Gene
pepA, BBta_3832
Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi263 – 2631Manganese 2 By similarity
Metal bindingi268 – 2681Manganese 1 By similarity
Metal bindingi268 – 2681Manganese 2 By similarity
Active sitei275 – 2751 Reviewed prediction
Metal bindingi286 – 2861Manganese 2 By similarity
Metal bindingi345 – 3451Manganese 1 By similarity
Metal bindingi347 – 3471Manganese 1 By similarity
Metal bindingi347 – 3471Manganese 2 By similarity
Active sitei349 – 3491 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBSP288000:GJBR-3656-MONOMER.

Protein family/group databases

MEROPSiM17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:BBta_3832
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000000246: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Probable cytosol aminopeptidaseUniRule annotation
PRO_1000019887Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288000.BBta_3832.

Structurei

3D structure databases

ProteinModelPortaliA5EIB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiDSQFADM.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5EIB4-1 [UniParc]FASTAAdd to Basket

« Hide

MSDTVKVGFV PLSTAPRGIL VAFCDESLRL GAATDKALGG AAELIQRAAA    50
AARFKGKDGA VLDLLAPQGI KIQRLLVIGT GKSGDHKEKD FLKYGGTLAG 100
KLNAGTEPVM VMAELPSGPM TPDQASSLAA GIRLRAYRFD RYKTKKKDEE 150
AAVSAAISLA VADVAAAKKA FAPRSHVTDG VILARDLVNE PPNVLYPEEF 200
AKRASALRKL GVTVEILDVP AMKKLGMGAL LGVGQGSARP SRTVVMRYNG 250
GKKGDQPVAF IGKGVCFDTG GISIKPAGSM EDMKGDMGGA ACVVGLMHAL 300
AARKAKANVI GAIGLVENMP DGNAQRPGDI VTSMSGQTIE IINTDAEGRL 350
VLADVLWYVA TKFKPKFMID LATLTGAIMV ALGTEHAGLF ANNDDLAEKL 400
LKAGQETGEK VWRMPLGPEY DKLIDSQFAD MKNTGGRHGG SITAAQFLQR 450
FVSDTPWAHL DIAGTAMGAP KSEVNQSWGS GYGVRLLDRL VWDCYEARS 499
Length:499
Mass (Da):52,627
Last modified:June 12, 2007 - v1
Checksum:i6CE6EBAE4B899EF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ35908.1.
RefSeqiWP_012043913.1. NC_009485.1.
YP_001239814.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ35908; ABQ35908; BBta_3832.
GeneIDi5154721.
KEGGibbt:BBta_3832.
PATRICi21208457. VBIBraSp29847_3903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ35908.1 .
RefSeqi WP_012043913.1. NC_009485.1.
YP_001239814.1. NC_009485.1.

3D structure databases

ProteinModelPortali A5EIB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288000.BBta_3832.

Protein family/group databases

MEROPSi M17.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ35908 ; ABQ35908 ; BBta_3832 .
GeneIDi 5154721.
KEGGi bbt:BBta_3832.
PATRICi 21208457. VBIBraSp29847_3903.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi DSQFADM.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci BSP288000:GJBR-3656-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BTAi1 / ATCC BAA-1182.

Entry informationi

Entry nameiAMPA_BRASB
AccessioniPrimary (citable) accession number: A5EIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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