A5EG87 (TYPH_BRASB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

BBta_3062

Organism

Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]

Taxonomic identifier

288000 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Sequence caution	The sequence ABQ35181.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314697

Sequences

	Sequence		Length	Mass (Da)
	A5EG87 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 02CE1A5A2442C6FD	FASTA	511	54,383
	10 20 30 40 50 60 MSTIDSARPQ LKIRSVALDT GRENVVVISR RSRALRPEVF SGFSRVELRC NSRTLLATLL 70 80 90 100 110 120 ITDDDALVGP DEIGLSQPAL RRFAEPAGTF ATVSPATPPD SLEAVRAKIR GETLSDQAIS 130 140 150 160 170 180 AVIDDLAHYR YSDMEIAAFL IGSASFMTSG ELLALTRAMA NAGTQLKWPE PVVVDKHCIG 190 200 210 220 230 240 GIPGNRTSMV VVPIVAAHGL TIPKTSSRAI TSPAGTADTM EVLARVNVGA EEMKSIVAAC 250 260 270 280 290 300 NGCVIWGGHV NLSPADDILI SVERPLSLDT REQMVASILS KKLAAGSTHL LLDLPVGPTA 310 320 330 340 350 360 KLSSGAEAMR LRKLFEFVGD RFGLNVEVIT TDGRQPIGNG IGPVLEARDV MAVLGNEPGA 370 380 390 400 410 420 PADLREKSLR LAAHLLEYDP KLRGGAGYQR ARELLDSGAA LKQMQKIIDA QGPTTSRNEL 430 440 450 460 470 480 GDLAFDVKAG RDGIVSAIDC LRLNRLARTA GAPINKGAGI RLFKKIGDRV DQGEPLYRVF 490 500 510 TCDPSEHDLA VAAAAADHGY GFADEPNGHQ R

References

[1]

"Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia." Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C., Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L., Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z. , Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A., Medigue C., Sadowsky M. Science 316:1307-1312(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BTAi1 / ATCC BAA-1182.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000494 Genomic DNA. Translation: ABQ35181.1. Different initiation.
RefSeq	YP_001239087.1. NC_009485.1.
3D structure databases
ProteinModelPortal	A5EG87.
ModBase	Search...
Protein-protein interaction databases
STRING	288000.BBta_3062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ35181; ABQ35181; BBta_3062.
GeneID	5149443.
KEGG	bbt:BBta_3062.
PATRIC	21206947. VBIBraSp29847_3156.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	BSP288000:GJBR-2911-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_BRASB

Accession

Primary (citable) accession number: A5EG87

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program