Reviewed, UniProtKB/Swiss-Prot A5EEP1 (AROC_BRASB)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BBta_2470

Organism

Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]

Taxonomic identifier

288000 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Chorismate synthase HAMAP MF_00300		PRO_1000022463

Sequences

	Sequence		Length	Mass (Da)
	A5EEP1-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 62EC6C41D0549332	FASTA	361	38,700
	10 20 30 40 50 60 MSFNTFGHMF RVTTFGESHG VAIGCVVDGC PPRIPLEPAE IQVDLDRRRP GQSRFTTQRQ 70 80 90 100 110 120 EPDQVKILSG VMPDPDTGAQ VTTGTPIALL IENTDQRSKD YSEIKDKFRP GHADFTYEAK 130 140 150 160 170 180 YGLRDYRGGG RSSARETATR VAAGAIARKI LAGVKVRGAL VQMGPHKIDR AKWDWDEIAR 190 200 210 220 230 240 NPFFCPDKDK AAFFEDYLDG IRKSGSSIGA VLEITAEGVP AGLGAPLYGK LDADLAAAMM 250 260 270 280 290 300 SINAVKGVEI GAGFAAAELT GEENADEMRS ANDGTRFLSN NAGGILGGIA TGQPIVVRFA 310 320 330 340 350 360 VKPTSSILTP RQTVDRAGHE TEILTKGRHD PCVGIRAVPV GEAMMACVLA DHLLRHRGQV G

References

[1]

"Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia." Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C., Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L., Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z. , Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A., Medigue C., Sadowsky M. Science 316:1307-1312(2007) [PubMed: 17540897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000494 Genomic DNA. Translation: ABQ34635.1.
RefSeq	YP_001238541.1.
3D structure databases
SMR	A5EEP1. Positions 3-359.
ModBase	Search...
Protein-protein interaction databases
STRING	A5EEP1.
Genome annotation databases
GeneID	5152219.
GenomeReviews	Gene locus BBta_2470 in contig CP000494_GR.
KEGG	bbt:BBta_2470.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	SRFTTQR.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BRASB

Accession

Primary (citable) accession number: A5EEP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 12, 2007
Last modified:	February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)