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A5EE78 (A5EE78_BRASB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:BBta_2296
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP] EMBL ABQ34472.1
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Ontologies

Keywords
   Biological processPorphyrin biosynthesis HAMAP MF_00333
   Cellular componentCytoplasm HAMAP MF_00333
   Molecular functionOxidoreductase HAMAP MF_00333 EMBL ABQ34472.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: HAMAP

protein homodimerization activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region68 – 7710Important for dimerization By similarity HAMAP MF_00333
Region128 – 1303Substrate binding By similarity HAMAP MF_00333
Region260 – 29536Important for dimerization By similarity HAMAP MF_00333
Region278 – 2836Substrate binding By similarity HAMAP MF_00333

Sites

Active site1261Proton donor By similarity HAMAP MF_00333
Binding site1121Substrate By similarity HAMAP MF_00333
Site1951Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
A5EE78 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: A4A3C262E4DDB9A8

FASTA29533,322
        10         20         30         40         50         60 
MTTAAIEDRK ARARAWFESL RDQICAAFEQ LEDEAPAALY PRQPGRFVRT PWQRTDHSGA 

        70         80         90        100        110        120 
PGGGGVMGMM HGRLFEKVGV HCSTVHGEFA PEFRSQIPGA SEDPRFWASG ISLIAHLWSP 

       130        140        150        160        170        180 
HVPAVHMNTR FVVTTKAWFG GGADLTPVLD RRRNQEDPDT LAFHAALQGA CDAHATVAPY 

       190        200        210        220        230        240 
DKYKRWCDEY FYLPHRKEPR GIGGIFYDHH DSGDWEADLA FTQDVGRAFL KVYPELVRRN 

       250        260        270        280        290 
FGAAWTEADR EEQLIRRGRY VEFNLLYDRG TTFGLKTGGN VESILSSMPP EVKWP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ34472.1.
RefSeqYP_001238378.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5EE78.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5EE78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5153906.
GenomeReviewsGene locus BBta_2296 in contig CP000494_GR.
KEGGbbt:BBta_2296.
PATRIC21205467. VBIBraSp29847_2418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5EE78_BRASB
AccessionPrimary (citable) accession number: A5EE78
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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