Reviewed, UniProtKB/Swiss-Prot A5EDY0 (DCUP_BRASB)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	BBta_2192

Organism

Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]

Taxonomic identifier

288000 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325629
Regions
	Region	23 – 27	5	Substrate binding By similarity
Sites
	Binding site	73	1	Substrate By similarity
	Binding site	149	1	Substrate By similarity
	Binding site	204	1	Substrate By similarity
	Binding site	320	1	Substrate By similarity
	Site	73	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5EDY0-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: D2BE88E3937175D6	FASTA	343	37,176
	10 20 30 40 50 60 MNKPFIDVLA GQRQSAPPVW MMRQAGRYLP EYREVRAKAG GFLDLCFNPE MAAEVTLQPI 70 80 90 100 110 120 RRFGFDAAII FSDILVIPHA LGRSVRFEVG EGPRLDPLDT PEKIATLAGH ADLTKLDAVF 130 140 150 160 170 180 EALRRVRAEL PKSTALIGFC GAPWTVATYM VAGQGTPDQA PARLLAYAQP EAFSRIIDAL 190 200 210 220 230 240 VESSIAYLLK QLEAGADALQ IFDTWAGVLS PREFARWSAA PTRRIVEGVR NARPDAKIIG 250 260 270 280 290 300 FPRGAGALLP GYVAETAVDA VSIDWTAEPS LVRERVQSKV AVQGNLDPLA LMTGGAALDQ 310 320 330 340 AVDDVLASYA GGRHIFNLGH GILPETPIAH VEQMLKRVRA YKG

References

[1]

"Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia." Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C., Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L., Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z. , Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A., Medigue C., Sadowsky M. Science 316:1307-1312(2007) [PubMed: 17540897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000494 Genomic DNA. Translation: ABQ34374.1.
RefSeq	YP_001238280.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5EDY0.
Genome annotation databases
GeneID	5152355.
GenomeReviews	Gene locus BBta_2192 in contig CP000494_GR.
KEGG	bbt:BBta_2192.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VFTKGGG.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BRASB

Accession

Primary (citable) accession number: A5EDY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 12, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)