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A5EBP8 (HEMH_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:BBta_1357
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Ferrochelatase HAMAP MF_00323
PRO_1000019273

Sites

Metal binding2211Iron By similarity
Metal binding3021Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A5EBP8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 1690CA3733F1A046

FASTA35139,131
        10         20         30         40         50         60 
MTAAISFDNA RSPDNALPLP AASTARVGVL LVNLGTPDTA DAAGVRVYLK EFLSDRRVIE 

        70         80         90        100        110        120 
DQGLLWKIIL NGIILNVRPR KKAKDYQSIW NTEKNESPLK TITRAQSEKL SAALADRSHV 

       130        140        150        160        170        180 
IVDWAMRYGN PSIKAGVDGL MAKGCDRILV VPLYPQYSAA TSATVCDEAF RVLTELRAQP 

       190        200        210        220        230        240 
TLRVTPPYYN DDFYIEALAV SIEEHLKTLS YKPELIVASF HGMPKEYVDK GDPYREQCVA 

       250        260        270        280        290        300 
TTELLRKRLG MDDTKLLLTF QSRFGFSEWL QPYTDKTIEK LAKDGVKRIA VVMPGFAADC 

       310        320        330        340        350 
LETLEEISGE NCEIFKHNGG EEFSAVPCLN DSAPGMEVLR QLVLRELQGW L

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ33592.1.
RefSeqYP_001237498.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5EBP8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5EBP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5156027.
GenomeReviewsGene locus BBta_1357 in contig CP000494_GR.
KEGGbbt:BBta_1357.
PATRIC21203680. VBIBraSp29847_1527.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_BRASB
AccessionPrimary (citable) accession number: A5EBP8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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