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A5EAG1

- A5EAG1_BRASB

UniProt

A5EAG1 - A5EAG1_BRASB

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Protein
Histidinol dehydrogenase
Gene
hisD, BBta_0897
Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarityUniRule annotation
Binding sitei191 – 1911NAD By similarityUniRule annotation
Binding sitei214 – 2141NAD By similarityUniRule annotation
Binding sitei237 – 2371Substrate By similarityUniRule annotation
Metal bindingi259 – 2591Zinc By similarityUniRule annotation
Binding sitei259 – 2591Substrate By similarityUniRule annotation
Metal bindingi262 – 2621Zinc By similarityUniRule annotation
Binding sitei262 – 2621Substrate By similarityUniRule annotation
Active sitei327 – 3271Proton acceptor By similarityUniRule annotation
Active sitei328 – 3281Proton acceptor By similarityUniRule annotation
Binding sitei328 – 3281Substrate By similarityUniRule annotation
Metal bindingi361 – 3611Zinc By similarityUniRule annotation
Binding sitei361 – 3611Substrate By similarityUniRule annotation
Binding sitei415 – 4151Substrate By similarityUniRule annotation
Metal bindingi420 – 4201Zinc By similarityUniRule annotation
Binding sitei420 – 4201Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, NADUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBSP288000:GJBR-861-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
Gene namesi
Name:hisDUniRule annotationImported
Ordered Locus Names:BBta_0897Imported
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)Imported
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000000246: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi288000.BBta_0897.

Structurei

3D structure databases

ProteinModelPortaliA5EAG1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5EAG1-1 [UniParc]FASTAAdd to Basket

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MPIRLSRAHA DFDAQFRQFL AAKRETSADV EAAARAIVDD VAKRGDAALL    50
EATRKFDRLE LTAASLRVTA DEIEAAVTAC DAATLDALKF ARDRIEAFHL 100
KQLPQDQRFT DAAGVELGWR WSAIESAGLY VPGGTAAYPS SVLMNAIPAK 150
VAGVSRLVMV VPAPDGKLNP LVLAAAHLGG VSEIYRVGGA QAVAALAHGT 200
ATIAPVVKIV GPGNAYVAAA KRLVFGKVGI DMIAGPSEVL VIADDSGNAD 250
WIAADLLAQA EHDASAQSIL ITDSRRLADD VARAVEGQLK TLPRAQIAGA 300
SWADFGAIIE VEDLDQAVPL ADAIAAEHLE IMTRDPDAFA ARVRNAGAIF 350
LGAHTPEAIG DYVGGSNHVL PTARSARFSS GLGVLDFMKR TSLLKCGPEQ 400
LRALGPAAMT LGKAEGLDAH SRSVGIRLNL P 431
Length:431
Mass (Da):45,076
Last modified:June 12, 2007 - v1
Checksum:i2C77F0E4C8FF11EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ33155.1.
RefSeqiWP_012041205.1. NC_009485.1.
YP_001237061.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ33155; ABQ33155; BBta_0897.
GeneIDi5152187.
KEGGibbt:BBta_0897.
PATRICi21202774. VBIBraSp29847_1083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ33155.1 .
RefSeqi WP_012041205.1. NC_009485.1.
YP_001237061.1. NC_009485.1.

3D structure databases

ProteinModelPortali A5EAG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288000.BBta_0897.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ33155 ; ABQ33155 ; BBta_0897 .
GeneIDi 5152187.
KEGGi bbt:BBta_0897.
PATRICi 21202774. VBIBraSp29847_1083.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BSP288000:GJBR-861-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BTAi1 / ATCC BAA-1182.

Entry informationi

Entry nameiA5EAG1_BRASB
AccessioniPrimary (citable) accession number: A5EAG1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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