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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationSAAS annotationNote: Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADUniRule annotation
Binding sitei191 – 1911NADUniRule annotation
Binding sitei214 – 2141NADUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Metal bindingi262 – 2621ZincUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Active sitei327 – 3271Proton acceptorUniRule annotation
Active sitei328 – 3281Proton acceptorUniRule annotation
Binding sitei328 – 3281SubstrateUniRule annotation
Metal bindingi361 – 3611ZincUniRule annotation
Binding sitei361 – 3611SubstrateUniRule annotation
Binding sitei415 – 4151SubstrateUniRule annotation
Metal bindingi420 – 4201ZincUniRule annotation
Binding sitei420 – 4201SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciBSP288000:GJBR-861-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotationImported
Ordered Locus Names:BBta_0897Imported
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)Imported
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000000246: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi288000.BBta_0897.

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5EAG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIRLSRAHA DFDAQFRQFL AAKRETSADV EAAARAIVDD VAKRGDAALL
60 70 80 90 100
EATRKFDRLE LTAASLRVTA DEIEAAVTAC DAATLDALKF ARDRIEAFHL
110 120 130 140 150
KQLPQDQRFT DAAGVELGWR WSAIESAGLY VPGGTAAYPS SVLMNAIPAK
160 170 180 190 200
VAGVSRLVMV VPAPDGKLNP LVLAAAHLGG VSEIYRVGGA QAVAALAHGT
210 220 230 240 250
ATIAPVVKIV GPGNAYVAAA KRLVFGKVGI DMIAGPSEVL VIADDSGNAD
260 270 280 290 300
WIAADLLAQA EHDASAQSIL ITDSRRLADD VARAVEGQLK TLPRAQIAGA
310 320 330 340 350
SWADFGAIIE VEDLDQAVPL ADAIAAEHLE IMTRDPDAFA ARVRNAGAIF
360 370 380 390 400
LGAHTPEAIG DYVGGSNHVL PTARSARFSS GLGVLDFMKR TSLLKCGPEQ
410 420 430
LRALGPAAMT LGKAEGLDAH SRSVGIRLNL P
Length:431
Mass (Da):45,076
Last modified:June 12, 2007 - v1
Checksum:i2C77F0E4C8FF11EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000494 Genomic DNA. Translation: ABQ33155.1.
RefSeqiWP_012041205.1. NC_009485.1.
YP_001237061.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ33155; ABQ33155; BBta_0897.
GeneIDi5152187.
KEGGibbt:BBta_0897.
PATRICi21202774. VBIBraSp29847_1083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000494 Genomic DNA. Translation: ABQ33155.1.
RefSeqiWP_012041205.1. NC_009485.1.
YP_001237061.1. NC_009485.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288000.BBta_0897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ33155; ABQ33155; BBta_0897.
GeneIDi5152187.
KEGGibbt:BBta_0897.
PATRICi21202774. VBIBraSp29847_1083.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciBSP288000:GJBR-861-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BTAi1 / ATCC BAA-1182Imported.

Entry informationi

Entry nameiA5EAG1_BRASB
AccessioniPrimary (citable) accession number: A5EAG1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.