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A5EAG1 (A5EAG1_BRASB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024 PIRNR PIRNR000099 SAAS SAAS012131

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024 PIRNR PIRNR000099 SAAS SAAS012131

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024 PIRSR PIRSR000099-4 SAAS SAAS012131

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024 PIRNR PIRNR000099 SAAS SAAS012131

Sequence similarities

Belongs to the histidinol dehydrogenase family. RuleBase RU004175 HAMAP-Rule MF_01024 PIRNR PIRNR000099

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3271Proton acceptor By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-1
Active site3281Proton acceptor By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-1
Metal binding2591Zinc By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-4
Metal binding2621Zinc By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-4
Metal binding3611Zinc By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-4
Metal binding4201Zinc By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-4
Binding site1301NAD By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-2
Binding site1911NAD By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-2
Binding site2141NAD By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-2
Binding site2371Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3
Binding site2591Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3
Binding site2621Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3
Binding site3281Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3
Binding site3611Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3
Binding site4151Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3
Binding site4201Substrate By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-3

Sequences

Sequence LengthMass (Da)Tools
A5EAG1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 2C77F0E4C8FF11EC

FASTA43145,076
        10         20         30         40         50         60 
MPIRLSRAHA DFDAQFRQFL AAKRETSADV EAAARAIVDD VAKRGDAALL EATRKFDRLE 

        70         80         90        100        110        120 
LTAASLRVTA DEIEAAVTAC DAATLDALKF ARDRIEAFHL KQLPQDQRFT DAAGVELGWR 

       130        140        150        160        170        180 
WSAIESAGLY VPGGTAAYPS SVLMNAIPAK VAGVSRLVMV VPAPDGKLNP LVLAAAHLGG 

       190        200        210        220        230        240 
VSEIYRVGGA QAVAALAHGT ATIAPVVKIV GPGNAYVAAA KRLVFGKVGI DMIAGPSEVL 

       250        260        270        280        290        300 
VIADDSGNAD WIAADLLAQA EHDASAQSIL ITDSRRLADD VARAVEGQLK TLPRAQIAGA 

       310        320        330        340        350        360 
SWADFGAIIE VEDLDQAVPL ADAIAAEHLE IMTRDPDAFA ARVRNAGAIF LGAHTPEAIG 

       370        380        390        400        410        420 
DYVGGSNHVL PTARSARFSS GLGVLDFMKR TSLLKCGPEQ LRALGPAAMT LGKAEGLDAH 

       430 
SRSVGIRLNL P

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000494 Genomic DNA. Translation: ABQ33155.1.
RefSeqYP_001237061.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5EAG1.
ModBaseSearch...

Protein-protein interaction databases

STRING288000.BBta_0897.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ33155; ABQ33155; BBta_0897.
GeneID5152187.
KEGGbbt:BBta_0897.
PATRIC21202774. VBIBraSp29847_1083.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPEHLEVW.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycBSP288000:GJBR-861-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5EAG1_BRASB
AccessionPrimary (citable) accession number: A5EAG1
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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