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A5E8V7

- PNCB_BRASB

UniProt

A5E8V7 - PNCB_BRASB

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBSP288000:GJBR-301-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BBta_0308
OrganismiBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Taxonomic identifieri288000 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000000246: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146833Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288000.BBta_0308.

Structurei

3D structure databases

ProteinModelPortaliA5E8V7.
SMRiA5E8V7. Positions 1-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A5E8V7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVTDIASRT YNHGWRLDPI VRSLLDTDFY KLLMLQMIRE FYPDQKVTFS
60 70 80 90 100
VINRTKRVRL GDVIDEGELR AQLDHARTIR FTKKELIWLA GNTFYGKTHM
110 120 130 140 150
FSPDFLAWLA HFRLPDYELH KADGQYELHF HGPWTHTTMW EIPALAIVNE
160 170 180 190 200
LRSRQAMKGQ GRFALDVLFA RAKAKLWAKV ERLRRLEGLR LSDFGTRRRH
210 220 230 240 250
GFLWQRWCVE AVKEGLGPSF TGTSNVLLAM DNDLEAIGTN AHELPMVAAA
260 270 280 290 300
LARDDDELRF APYRILDQWR QTYAGNLLIA LPDAFGTKAF LRDAPDWVAD
310 320 330 340 350
WTGFRPDSAP PIEAGEEIIA WWKSKGRDPK QKLLVFSDAM DVESIEQIHH
360 370 380 390 400
RFSDRVRLSF GWGTNLTNDF VGCAPDGSVD LDPISLVCKV TSVDGQPAVK
410 420 430
LSDNPEKATG DPAEIARYLR VFGDAGRVRT PVVV
Length:434
Mass (Da):49,497
Last modified:June 12, 2007 - v1
Checksum:i7A1EE8DE95BB03E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ32601.1.
RefSeqiWP_012040655.1. NC_009485.1.
YP_001236507.1. NC_009485.1.

Genome annotation databases

EnsemblBacteriaiABQ32601; ABQ32601; BBta_0308.
GeneIDi5153185.
KEGGibbt:BBta_0308.
PATRICi21201632. VBIBraSp29847_0516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000494 Genomic DNA. Translation: ABQ32601.1 .
RefSeqi WP_012040655.1. NC_009485.1.
YP_001236507.1. NC_009485.1.

3D structure databases

ProteinModelPortali A5E8V7.
SMRi A5E8V7. Positions 1-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288000.BBta_0308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ32601 ; ABQ32601 ; BBta_0308 .
GeneIDi 5153185.
KEGGi bbt:BBta_0308.
PATRICi 21201632. VBIBraSp29847_0516.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BSP288000:GJBR-301-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BTAi1 / ATCC BAA-1182.

Entry informationi

Entry nameiPNCB_BRASB
AccessioniPrimary (citable) accession number: A5E8V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 12, 2007
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3