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A5E8I8 (NTPA_BRASB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:BBta_0185
OrganismBradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) [Complete proteome] [HAMAP]
Taxonomic identifier288000 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
PRO_1000087376

Regions

Region16 – 216Substrate binding By similarity
Region77 – 782Substrate binding By similarity

Sites

Metal binding481Magnesium or manganese By similarity
Metal binding771Magnesium or manganese By similarity
Binding site1661Substrate By similarity
Binding site1861Substrate By similarity
Binding site1991Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A5E8I8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 2ADDBB8ADCB2E626

FASTA21422,849
        10         20         30         40         50         60 
MSSSHRKLSG RIVIATHNPG KLAEMRELLA PYGVEAVSAG ELSLGEPDET GETFQANARI 

        70         80         90        100        110        120 
KAVAAADAAQ LPAFADDSGI VVHALDGAPG IYSARWAGPD KDFTAAMTRI ERLLQERGAT 

       130        140        150        160        170        180 
GPDKRGAHFV SALCVAWPDG HVEEVEARVD GTLVWPPRGS AGFGYDPMFL PEGHDRTFGE 

       190        200        210 
MTSLEKHGLP PLGLGLSHRA RAFVKLAEIC LDQR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000494 Genomic DNA. Translation: ABQ32482.1.
RefSeqYP_001236388.1. NC_009485.1.

3D structure databases

ProteinModelPortalA5E8I8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5E8I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5149121.
GenomeReviewsGene locus BBta_0185 in contig CP000494_GR.
KEGGbbt:BBta_0185.
PATRIC21201370. VBIBraSp29847_0389.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHBG697237.
OMAGVYTADW.
ProtClustDBPRK00120.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_BRASB
AccessionPrimary (citable) accession number: A5E8I8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families