ID   HIS4_BRASB              Reviewed;         247 AA.
AC   A5E8E8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   16-JUN-2009, entry version 12.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=BBta_0145;
OS   Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=288000;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S.,
RA   Rouy Z., Mangenot S., Segurens B., Dossat C., Franck W.L.,
RA   Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P.,
RA   Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A.,
RA   Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic
RT   bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CP000494; ABQ32442.1; -; Genomic_DNA.
DR   RefSeq; YP_001236348.1; -.
DR   GeneID; 5149957; -.
DR   GenomeReviews; CP000494_GR; BBta_0145.
DR   KEGG; bbt:BBta_0145; -.
DR   OMA; A5E8E8; VATRGWL.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    247       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_1000063187.
FT   ACT_SITE      8      8       Proton acceptor (By similarity).
FT   ACT_SITE    129    129       Proton donor (By similarity).
SQ   SEQUENCE   247 AA;  25858 MW;  C55E48CC32172C72 CRC64;
     MILFPAIDLK NGQCVRLEQG DMARATVFNL DPAAQAKSFA DQGFDYLHVV DLDGAFAGKP
     MNAQAVEAML KVVKMPVQLG GGIRDLKTVE AWLNKGITRV IIGTAAVRDP ELVKTAAKAF
     PGRVAVGLDA RDGKVAVEGW AETSEVTALD IAKRFEDAGV AAIIFTDIAR DGLLKGLNLD
     ATIALGDAVS IPVIASGGLA SIEDVKAMLT PRARKLEGAI AGRALYDGRL DPAEALALIR
     AARKAGA
//