Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A5E751 (KEX1_LODEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:LELG_05440
OrganismLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) [Complete proteome]
Taxonomic identifier379508 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces

Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 702683Pheromone-processing carboxypeptidase KEX1
PRO_0000411924

Regions

Topological domain20 – 554535Lumenal Potential
Transmembrane555 – 57521Helical; Potential
Topological domain576 – 702127Cytoplasmic Potential

Sites

Active site1881 By similarity
Active site3991 By similarity
Active site4571 By similarity

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation4461N-linked (GlcNAc...) Potential
Glycosylation4541N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A5E751 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: C72913D44E37B44D

FASTA70279,550
        10         20         30         40         50         60 
MLISSIYTIC LFIITSVLAI PPKEGSDSDP AKQYLVTDLP GLHENIDDDF KPIMYAGQVE 

        70         80         90        100        110        120 
LFPENNTMYF FWKFTDPKKS TDSAYSKRSI FWLNGGPGCS SMDGALLETG PFRINQDEKV 

       130        140        150        160        170        180 
VMNNGSWHKA GDVVYVDQPA GTGFSYTDQG KWLHDLPDMA FYFLKFMEKY YEIYPEEIDN 

       190        200        210        220        230        240 
DIYFAGESYA GQYIPYIADA ILKRNAKLEE GQKKYNLKSL LIGNGWVSPN EQSLSYLPFF 

       250        260        270        280        290        300 
IENKLIDKEN PRWMELLGDH EKCQRIVDGI DSKFDDKELN PAELDSNLCE GILTKLLSAT 

       310        320        330        340        350        360 
VNGDGADDDQ RCINMYDFTL RDSWPGCGIN WPFELKYVTP FLRNDEVKHD LNLRVMKTWR 

       370        380        390        400        410        420 
ECSGRVGRNF NAQHSFPSVH LLPDLLKQVP IILFSGMNDI ICNSKGTLQY VLKLNWNGRK 

       430        440        450        460        470        480 
GFENPDAKLD WIHDDKKVGY VIQERNLTFI DIYNSSHMVP YDLPEVSRAL LEIATNNYDI 

       490        500        510        520        530        540 
RDVDETNQNL VTYPLGVQKK GKIEVNPPST PSSNDDSTTS ETSDSQPDTV SSAGTSAEAE 

       550        560        570        580        590        600 
TETEAEPTVN KVARLIQLAV ILIVIWGLYL LYASWRARPS PIMKKNGGNG RKKNVQWADQ 

       610        620        630        640        650        660 
LSRFEEEADA SQLKGFFAKT MDRFRTTEGQ GSYARAQSDD YIDDIELGEG IGETQLDDFI 

       670        680        690        700 
IGSDDEREGE LEQPTHKSGN MDTDTNKNMK NSSNESKNKN TV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH981533 Genomic DNA. Translation: EDK47259.1.
RefSeqXP_001523214.1. XM_001523164.1.

3D structure databases

ProteinModelPortalA5E751.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36914.A5E751.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5230460.
KEGGlel:LELG_05440.

Phylogenomic databases

KOK01288.
OMATSHLYFV.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_LODEL
AccessionPrimary (citable) accession number: A5E751
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries