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A5E751

- KEX1_LODEL

UniProt

A5E751 - KEX1_LODEL

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881PROSITE-ProRule annotation
Active sitei399 – 3991PROSITE-ProRule annotation
Active sitei457 – 4571PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:LELG_05440
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 702683Pheromone-processing carboxypeptidase KEX1PRO_0000411924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36914.A5E751.

Structurei

3D structure databases

ProteinModelPortaliA5E751.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 554535LumenalSequence AnalysisAdd
BLAST
Topological domaini576 – 702127CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei555 – 57521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiA5E751.
KOiK01288.
OMAiTSHLYFV.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5E751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLISSIYTIC LFIITSVLAI PPKEGSDSDP AKQYLVTDLP GLHENIDDDF
60 70 80 90 100
KPIMYAGQVE LFPENNTMYF FWKFTDPKKS TDSAYSKRSI FWLNGGPGCS
110 120 130 140 150
SMDGALLETG PFRINQDEKV VMNNGSWHKA GDVVYVDQPA GTGFSYTDQG
160 170 180 190 200
KWLHDLPDMA FYFLKFMEKY YEIYPEEIDN DIYFAGESYA GQYIPYIADA
210 220 230 240 250
ILKRNAKLEE GQKKYNLKSL LIGNGWVSPN EQSLSYLPFF IENKLIDKEN
260 270 280 290 300
PRWMELLGDH EKCQRIVDGI DSKFDDKELN PAELDSNLCE GILTKLLSAT
310 320 330 340 350
VNGDGADDDQ RCINMYDFTL RDSWPGCGIN WPFELKYVTP FLRNDEVKHD
360 370 380 390 400
LNLRVMKTWR ECSGRVGRNF NAQHSFPSVH LLPDLLKQVP IILFSGMNDI
410 420 430 440 450
ICNSKGTLQY VLKLNWNGRK GFENPDAKLD WIHDDKKVGY VIQERNLTFI
460 470 480 490 500
DIYNSSHMVP YDLPEVSRAL LEIATNNYDI RDVDETNQNL VTYPLGVQKK
510 520 530 540 550
GKIEVNPPST PSSNDDSTTS ETSDSQPDTV SSAGTSAEAE TETEAEPTVN
560 570 580 590 600
KVARLIQLAV ILIVIWGLYL LYASWRARPS PIMKKNGGNG RKKNVQWADQ
610 620 630 640 650
LSRFEEEADA SQLKGFFAKT MDRFRTTEGQ GSYARAQSDD YIDDIELGEG
660 670 680 690 700
IGETQLDDFI IGSDDEREGE LEQPTHKSGN MDTDTNKNMK NSSNESKNKN

TV
Length:702
Mass (Da):79,550
Last modified:June 12, 2007 - v1
Checksum:iC72913D44E37B44D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981533 Genomic DNA. Translation: EDK47259.1.
RefSeqiXP_001523214.1. XM_001523164.1.

Genome annotation databases

GeneIDi5230460.
KEGGilel:LELG_05440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981533 Genomic DNA. Translation: EDK47259.1 .
RefSeqi XP_001523214.1. XM_001523164.1.

3D structure databases

ProteinModelPortali A5E751.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5E751.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5230460.
KEGGi lel:LELG_05440.

Phylogenomic databases

InParanoidi A5E751.
KOi K01288.
OMAi TSHLYFV.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry nameiKEX1_LODEL
AccessioniPrimary (citable) accession number: A5E751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3