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A5E751

- KEX1_LODEL

UniProt

A5E751 - KEX1_LODEL

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei188 – 1881PROSITE-ProRule annotation
    Active sitei399 – 3991PROSITE-ProRule annotation
    Active sitei457 – 4571PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:LELG_05440
    OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
    Taxonomic identifieri379508 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
    ProteomesiUP000001996: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 702683Pheromone-processing carboxypeptidase KEX1PRO_0000411924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi36914.A5E751.

    Structurei

    3D structure databases

    ProteinModelPortaliA5E751.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 554535LumenalSequence AnalysisAdd
    BLAST
    Topological domaini576 – 702127CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei555 – 57521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OMAiTSHLYFV.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5E751-1 [UniParc]FASTAAdd to Basket

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    MLISSIYTIC LFIITSVLAI PPKEGSDSDP AKQYLVTDLP GLHENIDDDF    50
    KPIMYAGQVE LFPENNTMYF FWKFTDPKKS TDSAYSKRSI FWLNGGPGCS 100
    SMDGALLETG PFRINQDEKV VMNNGSWHKA GDVVYVDQPA GTGFSYTDQG 150
    KWLHDLPDMA FYFLKFMEKY YEIYPEEIDN DIYFAGESYA GQYIPYIADA 200
    ILKRNAKLEE GQKKYNLKSL LIGNGWVSPN EQSLSYLPFF IENKLIDKEN 250
    PRWMELLGDH EKCQRIVDGI DSKFDDKELN PAELDSNLCE GILTKLLSAT 300
    VNGDGADDDQ RCINMYDFTL RDSWPGCGIN WPFELKYVTP FLRNDEVKHD 350
    LNLRVMKTWR ECSGRVGRNF NAQHSFPSVH LLPDLLKQVP IILFSGMNDI 400
    ICNSKGTLQY VLKLNWNGRK GFENPDAKLD WIHDDKKVGY VIQERNLTFI 450
    DIYNSSHMVP YDLPEVSRAL LEIATNNYDI RDVDETNQNL VTYPLGVQKK 500
    GKIEVNPPST PSSNDDSTTS ETSDSQPDTV SSAGTSAEAE TETEAEPTVN 550
    KVARLIQLAV ILIVIWGLYL LYASWRARPS PIMKKNGGNG RKKNVQWADQ 600
    LSRFEEEADA SQLKGFFAKT MDRFRTTEGQ GSYARAQSDD YIDDIELGEG 650
    IGETQLDDFI IGSDDEREGE LEQPTHKSGN MDTDTNKNMK NSSNESKNKN 700
    TV 702
    Length:702
    Mass (Da):79,550
    Last modified:June 12, 2007 - v1
    Checksum:iC72913D44E37B44D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981533 Genomic DNA. Translation: EDK47259.1.
    RefSeqiXP_001523214.1. XM_001523164.1.

    Genome annotation databases

    GeneIDi5230460.
    KEGGilel:LELG_05440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981533 Genomic DNA. Translation: EDK47259.1 .
    RefSeqi XP_001523214.1. XM_001523164.1.

    3D structure databases

    ProteinModelPortali A5E751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36914.A5E751.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5230460.
    KEGGi lel:LELG_05440.

    Phylogenomic databases

    KOi K01288.
    OMAi TSHLYFV.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

    Entry informationi

    Entry nameiKEX1_LODEL
    AccessioniPrimary (citable) accession number: A5E751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3