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A5E708 (NTE1_LODEL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:LELG_05397
OrganismLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) [Complete proteome]
Taxonomic identifier379508 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces

Protein attributes

Sequence length1443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14431443Lysophospholipase NTE1
PRO_0000295323

Regions

Topological domain1 – 5959Lumenal By similarity
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 14431363Cytoplasmic By similarity
Domain1136 – 1300165Patatin
Nucleotide binding619 – 750132cNMP 1
Nucleotide binding746 – 871126cNMP 2
Motif1167 – 11715GXSXG
Compositional bias219 – 2246Poly-Glu
Compositional bias351 – 3544Poly-Lys

Sites

Active site11691 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5E708 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 339E4C844D414585

FASTA1,443161,900
        10         20         30         40         50         60 
MEEELAIEDL PRLTGTVSLN NGLLHSIYNE TTVFKILRWS LVEIPKYILK LMSKNLEINL 

        70         80         90        100        110        120 
NVSSILIITL LIAAGILVIV RYKFLTGYSE DIKKGGSNAN TKALGQQSTN YPKSTSSGLF 

       130        140        150        160        170        180 
VEKSKDKKPS NYLDEFLMAI KVFGYLDKQV FHELTKSMTT QKLSRDEVMC LDEKIGFLIV 

       190        200        210        220        230        240 
VEGTAQVYTK VTKKSNRNKY DELGQNGRDE GEEADEDDEE EEKEVGDDGD DEMDVEAMRN 

       250        260        270        280        290        300 
RGNGTKNGKM HGLDTDNFEE NDDFLKLGEQ NYQLLNEVKS GAALSSLIST LDLFKPLKSE 

       310        320        330        340        350        360 
STLTPLDSMG SGVSLNLDYL DRAGARLKAL ENDSDADTRD STYPDIIVRP KKKKHSDTIT 

       370        380        390        400        410        420 
VAIIPQSAFE RVQMKYPKST SHIVTMVLTR LYKVTMTTIH NYLGLTGEIF KLEIELNKSC 

       430        440        450        460        470        480 
ELGLPRYLVD GLIERLSQGG SNERKQQAKH FRRSPLERTQ SRYVLLNSRV KSNNPGDLLS 

       490        500        510        520        530        540 
SVPISRDDPK LRVNKSSAPT LVDGSNRINF TDNIEETEEN SLRIAIIENI FKIVGINEAQ 

       550        560        570        580        590        600 
NLPHEQAPFR SLNSSANSSS IALNSPGYFS PNLPATTGRH HNVLKFSSND SLMNTISLSQ 

       610        620        630        640        650        660 
LKSQKTHSIS RGSTTQKQLY KRRNPITEMN IKDAFAKVME LKYIEPNTTV VQQNSVFCGL 

       670        680        690        700        710        720 
YYVINGSLEV HYKQAETYSK SATSKHVYTV GAGGIAGYMS CVVGFRSLVS IKTPKKTGAV 

       730        740        750        760        770        780 
VAYIAKNDYN QLLDKFYFLQ LPMATKLKSL LSKQVMTIDY ALEWCHIPAG NVLCSQGDLA 

       790        800        810        820        830        840 
NGFHVVLSGR FRVVRKEKRK GSNRDEVKVL GEYGHGESIG EVEVLTASRR SNSLIAVRDS 

       850        860        870        880        890        900 
ETARIPRTLF EILSFQNPSI MVKVSRLVAS KVLSSEKTLS QATHSFITSS SNESFISADY 

       910        920        930        940        950        960 
KTITILPTVS GLPVRDFADK LVHSLKAIGR NVIALDQALT LTHLGRHAFD ESLVRLKLSG 

       970        980        990       1000       1010       1020 
YFAYLEEEYE TVVYICDTPV QSNWTSTCIS QGDCVLLLAD ADDQYTASSV GEYEQLLIKM 

      1030       1040       1050       1060       1070       1080 
KTTARTDLCL IHQEKFVVSG STSRWLKNRM WVQGHHHIQM YIERNNETIG PGKKSFINEM 

      1090       1100       1110       1120       1130       1140 
AAKFVQNKSL ISKFEEARSK ALSWRREEQL KDLTLGSHKS DFLRLARILS NEAVGLVLGG 

      1150       1160       1170       1180       1190       1200 
GGSRGISHVG VVTALERHGI PVDLIGGTSI GSFVGGLYAK DYNIVSIYGR AKKFSKRVSS 

      1210       1220       1230       1240       1250       1260 
VWRMIFDLTY PVTSYITGYE FNRGIWKVFG FTEIEDFWIK YFCNSTNITN STMDIHESGY 

      1270       1280       1290       1300       1310       1320 
AWRFIRASMS LAGLLPPIAF KGCMLLDGGY LDNLPVMEMK RRGAKHIFAV DVGSVDDRTP 

      1330       1340       1350       1360       1370       1380 
MDYGDTLSGF WVVFNKWNPF SKHPNVPNMM DIQLRLAYVA SVNALEEAKR TPGVYYLRPP 

      1390       1400       1410       1420       1430       1440 
IDNYATLDFG KFDEIYQVGL GYADKLFTEW ENKKQLPEIA GFVKRDGMQN GGERIKMYRR 


NTM 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH981532 Genomic DNA. Translation: EDK47216.1.
RefSeqXP_001523551.1. XM_001523501.1.

3D structure databases

ProteinModelPortalA5E708.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36914.A5E708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5230489.
KEGGlel:LELG_05397.

Phylogenomic databases

eggNOGCOG0664.
KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_LODEL
AccessionPrimary (citable) accession number: A5E708
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families