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A5E708

- NTE1_LODEL

UniProt

A5E708 - NTE1_LODEL

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1169 – 11691By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi619 – 750132cNMP 1Add
    BLAST
    Nucleotide bindingi746 – 871126cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:LELG_05397
    OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
    Taxonomic identifieri379508 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
    ProteomesiUP000001996: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14431443Lysophospholipase NTE1PRO_0000295323Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi36914.A5E708.

    Structurei

    3D structure databases

    ProteinModelPortaliA5E708.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5959LumenalBy similarityAdd
    BLAST
    Topological domaini81 – 14431363CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1136 – 1300165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1167 – 11715GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 2246Poly-Glu
    Compositional biasi351 – 3544Poly-Lys

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5E708-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEELAIEDL PRLTGTVSLN NGLLHSIYNE TTVFKILRWS LVEIPKYILK     50
    LMSKNLEINL NVSSILIITL LIAAGILVIV RYKFLTGYSE DIKKGGSNAN 100
    TKALGQQSTN YPKSTSSGLF VEKSKDKKPS NYLDEFLMAI KVFGYLDKQV 150
    FHELTKSMTT QKLSRDEVMC LDEKIGFLIV VEGTAQVYTK VTKKSNRNKY 200
    DELGQNGRDE GEEADEDDEE EEKEVGDDGD DEMDVEAMRN RGNGTKNGKM 250
    HGLDTDNFEE NDDFLKLGEQ NYQLLNEVKS GAALSSLIST LDLFKPLKSE 300
    STLTPLDSMG SGVSLNLDYL DRAGARLKAL ENDSDADTRD STYPDIIVRP 350
    KKKKHSDTIT VAIIPQSAFE RVQMKYPKST SHIVTMVLTR LYKVTMTTIH 400
    NYLGLTGEIF KLEIELNKSC ELGLPRYLVD GLIERLSQGG SNERKQQAKH 450
    FRRSPLERTQ SRYVLLNSRV KSNNPGDLLS SVPISRDDPK LRVNKSSAPT 500
    LVDGSNRINF TDNIEETEEN SLRIAIIENI FKIVGINEAQ NLPHEQAPFR 550
    SLNSSANSSS IALNSPGYFS PNLPATTGRH HNVLKFSSND SLMNTISLSQ 600
    LKSQKTHSIS RGSTTQKQLY KRRNPITEMN IKDAFAKVME LKYIEPNTTV 650
    VQQNSVFCGL YYVINGSLEV HYKQAETYSK SATSKHVYTV GAGGIAGYMS 700
    CVVGFRSLVS IKTPKKTGAV VAYIAKNDYN QLLDKFYFLQ LPMATKLKSL 750
    LSKQVMTIDY ALEWCHIPAG NVLCSQGDLA NGFHVVLSGR FRVVRKEKRK 800
    GSNRDEVKVL GEYGHGESIG EVEVLTASRR SNSLIAVRDS ETARIPRTLF 850
    EILSFQNPSI MVKVSRLVAS KVLSSEKTLS QATHSFITSS SNESFISADY 900
    KTITILPTVS GLPVRDFADK LVHSLKAIGR NVIALDQALT LTHLGRHAFD 950
    ESLVRLKLSG YFAYLEEEYE TVVYICDTPV QSNWTSTCIS QGDCVLLLAD 1000
    ADDQYTASSV GEYEQLLIKM KTTARTDLCL IHQEKFVVSG STSRWLKNRM 1050
    WVQGHHHIQM YIERNNETIG PGKKSFINEM AAKFVQNKSL ISKFEEARSK 1100
    ALSWRREEQL KDLTLGSHKS DFLRLARILS NEAVGLVLGG GGSRGISHVG 1150
    VVTALERHGI PVDLIGGTSI GSFVGGLYAK DYNIVSIYGR AKKFSKRVSS 1200
    VWRMIFDLTY PVTSYITGYE FNRGIWKVFG FTEIEDFWIK YFCNSTNITN 1250
    STMDIHESGY AWRFIRASMS LAGLLPPIAF KGCMLLDGGY LDNLPVMEMK 1300
    RRGAKHIFAV DVGSVDDRTP MDYGDTLSGF WVVFNKWNPF SKHPNVPNMM 1350
    DIQLRLAYVA SVNALEEAKR TPGVYYLRPP IDNYATLDFG KFDEIYQVGL 1400
    GYADKLFTEW ENKKQLPEIA GFVKRDGMQN GGERIKMYRR NTM 1443
    Length:1,443
    Mass (Da):161,900
    Last modified:June 12, 2007 - v1
    Checksum:i339E4C844D414585
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981532 Genomic DNA. Translation: EDK47216.1.
    RefSeqiXP_001523551.1. XM_001523501.1.

    Genome annotation databases

    GeneIDi5230489.
    KEGGilel:LELG_05397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981532 Genomic DNA. Translation: EDK47216.1 .
    RefSeqi XP_001523551.1. XM_001523501.1.

    3D structure databases

    ProteinModelPortali A5E708.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36914.A5E708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5230489.
    KEGGi lel:LELG_05397.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

    Entry informationi

    Entry nameiNTE1_LODEL
    AccessioniPrimary (citable) accession number: A5E708
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3