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A5E708

- NTE1_LODEL

UniProt

A5E708 - NTE1_LODEL

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Protein

Lysophospholipase NTE1

Gene
NTE1, LELG_05397
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1169 – 11691 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi619 – 750132cNMP 1Add
BLAST
Nucleotide bindingi746 – 871126cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:LELG_05397
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959Lumenal By similarityAdd
BLAST
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Topological domaini81 – 14431363Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14431443Lysophospholipase NTE1PRO_0000295323Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36914.A5E708.

Structurei

3D structure databases

ProteinModelPortaliA5E708.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1136 – 1300165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1167 – 11715GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2246Poly-Glu
Compositional biasi351 – 3544Poly-Lys

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5E708-1 [UniParc]FASTAAdd to Basket

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MEEELAIEDL PRLTGTVSLN NGLLHSIYNE TTVFKILRWS LVEIPKYILK     50
LMSKNLEINL NVSSILIITL LIAAGILVIV RYKFLTGYSE DIKKGGSNAN 100
TKALGQQSTN YPKSTSSGLF VEKSKDKKPS NYLDEFLMAI KVFGYLDKQV 150
FHELTKSMTT QKLSRDEVMC LDEKIGFLIV VEGTAQVYTK VTKKSNRNKY 200
DELGQNGRDE GEEADEDDEE EEKEVGDDGD DEMDVEAMRN RGNGTKNGKM 250
HGLDTDNFEE NDDFLKLGEQ NYQLLNEVKS GAALSSLIST LDLFKPLKSE 300
STLTPLDSMG SGVSLNLDYL DRAGARLKAL ENDSDADTRD STYPDIIVRP 350
KKKKHSDTIT VAIIPQSAFE RVQMKYPKST SHIVTMVLTR LYKVTMTTIH 400
NYLGLTGEIF KLEIELNKSC ELGLPRYLVD GLIERLSQGG SNERKQQAKH 450
FRRSPLERTQ SRYVLLNSRV KSNNPGDLLS SVPISRDDPK LRVNKSSAPT 500
LVDGSNRINF TDNIEETEEN SLRIAIIENI FKIVGINEAQ NLPHEQAPFR 550
SLNSSANSSS IALNSPGYFS PNLPATTGRH HNVLKFSSND SLMNTISLSQ 600
LKSQKTHSIS RGSTTQKQLY KRRNPITEMN IKDAFAKVME LKYIEPNTTV 650
VQQNSVFCGL YYVINGSLEV HYKQAETYSK SATSKHVYTV GAGGIAGYMS 700
CVVGFRSLVS IKTPKKTGAV VAYIAKNDYN QLLDKFYFLQ LPMATKLKSL 750
LSKQVMTIDY ALEWCHIPAG NVLCSQGDLA NGFHVVLSGR FRVVRKEKRK 800
GSNRDEVKVL GEYGHGESIG EVEVLTASRR SNSLIAVRDS ETARIPRTLF 850
EILSFQNPSI MVKVSRLVAS KVLSSEKTLS QATHSFITSS SNESFISADY 900
KTITILPTVS GLPVRDFADK LVHSLKAIGR NVIALDQALT LTHLGRHAFD 950
ESLVRLKLSG YFAYLEEEYE TVVYICDTPV QSNWTSTCIS QGDCVLLLAD 1000
ADDQYTASSV GEYEQLLIKM KTTARTDLCL IHQEKFVVSG STSRWLKNRM 1050
WVQGHHHIQM YIERNNETIG PGKKSFINEM AAKFVQNKSL ISKFEEARSK 1100
ALSWRREEQL KDLTLGSHKS DFLRLARILS NEAVGLVLGG GGSRGISHVG 1150
VVTALERHGI PVDLIGGTSI GSFVGGLYAK DYNIVSIYGR AKKFSKRVSS 1200
VWRMIFDLTY PVTSYITGYE FNRGIWKVFG FTEIEDFWIK YFCNSTNITN 1250
STMDIHESGY AWRFIRASMS LAGLLPPIAF KGCMLLDGGY LDNLPVMEMK 1300
RRGAKHIFAV DVGSVDDRTP MDYGDTLSGF WVVFNKWNPF SKHPNVPNMM 1350
DIQLRLAYVA SVNALEEAKR TPGVYYLRPP IDNYATLDFG KFDEIYQVGL 1400
GYADKLFTEW ENKKQLPEIA GFVKRDGMQN GGERIKMYRR NTM 1443
Length:1,443
Mass (Da):161,900
Last modified:June 12, 2007 - v1
Checksum:i339E4C844D414585
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981532 Genomic DNA. Translation: EDK47216.1.
RefSeqiXP_001523551.1. XM_001523501.1.

Genome annotation databases

GeneIDi5230489.
KEGGilel:LELG_05397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981532 Genomic DNA. Translation: EDK47216.1 .
RefSeqi XP_001523551.1. XM_001523501.1.

3D structure databases

ProteinModelPortali A5E708.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5E708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5230489.
KEGGi lel:LELG_05397.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry nameiNTE1_LODEL
AccessioniPrimary (citable) accession number: A5E708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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