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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1169 – 11691By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi619 – 750132cNMP 1Add
BLAST
Nucleotide bindingi746 – 871126cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:LELG_05397
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959LumenalBy similarityAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 14431363CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14431443Lysophospholipase NTE1PRO_0000295323Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36914.A5E708.

Structurei

3D structure databases

ProteinModelPortaliA5E708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1136 – 1300165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1167 – 11715GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2246Poly-Glu
Compositional biasi351 – 3544Poly-Lys

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiA5E708.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5E708-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEELAIEDL PRLTGTVSLN NGLLHSIYNE TTVFKILRWS LVEIPKYILK
60 70 80 90 100
LMSKNLEINL NVSSILIITL LIAAGILVIV RYKFLTGYSE DIKKGGSNAN
110 120 130 140 150
TKALGQQSTN YPKSTSSGLF VEKSKDKKPS NYLDEFLMAI KVFGYLDKQV
160 170 180 190 200
FHELTKSMTT QKLSRDEVMC LDEKIGFLIV VEGTAQVYTK VTKKSNRNKY
210 220 230 240 250
DELGQNGRDE GEEADEDDEE EEKEVGDDGD DEMDVEAMRN RGNGTKNGKM
260 270 280 290 300
HGLDTDNFEE NDDFLKLGEQ NYQLLNEVKS GAALSSLIST LDLFKPLKSE
310 320 330 340 350
STLTPLDSMG SGVSLNLDYL DRAGARLKAL ENDSDADTRD STYPDIIVRP
360 370 380 390 400
KKKKHSDTIT VAIIPQSAFE RVQMKYPKST SHIVTMVLTR LYKVTMTTIH
410 420 430 440 450
NYLGLTGEIF KLEIELNKSC ELGLPRYLVD GLIERLSQGG SNERKQQAKH
460 470 480 490 500
FRRSPLERTQ SRYVLLNSRV KSNNPGDLLS SVPISRDDPK LRVNKSSAPT
510 520 530 540 550
LVDGSNRINF TDNIEETEEN SLRIAIIENI FKIVGINEAQ NLPHEQAPFR
560 570 580 590 600
SLNSSANSSS IALNSPGYFS PNLPATTGRH HNVLKFSSND SLMNTISLSQ
610 620 630 640 650
LKSQKTHSIS RGSTTQKQLY KRRNPITEMN IKDAFAKVME LKYIEPNTTV
660 670 680 690 700
VQQNSVFCGL YYVINGSLEV HYKQAETYSK SATSKHVYTV GAGGIAGYMS
710 720 730 740 750
CVVGFRSLVS IKTPKKTGAV VAYIAKNDYN QLLDKFYFLQ LPMATKLKSL
760 770 780 790 800
LSKQVMTIDY ALEWCHIPAG NVLCSQGDLA NGFHVVLSGR FRVVRKEKRK
810 820 830 840 850
GSNRDEVKVL GEYGHGESIG EVEVLTASRR SNSLIAVRDS ETARIPRTLF
860 870 880 890 900
EILSFQNPSI MVKVSRLVAS KVLSSEKTLS QATHSFITSS SNESFISADY
910 920 930 940 950
KTITILPTVS GLPVRDFADK LVHSLKAIGR NVIALDQALT LTHLGRHAFD
960 970 980 990 1000
ESLVRLKLSG YFAYLEEEYE TVVYICDTPV QSNWTSTCIS QGDCVLLLAD
1010 1020 1030 1040 1050
ADDQYTASSV GEYEQLLIKM KTTARTDLCL IHQEKFVVSG STSRWLKNRM
1060 1070 1080 1090 1100
WVQGHHHIQM YIERNNETIG PGKKSFINEM AAKFVQNKSL ISKFEEARSK
1110 1120 1130 1140 1150
ALSWRREEQL KDLTLGSHKS DFLRLARILS NEAVGLVLGG GGSRGISHVG
1160 1170 1180 1190 1200
VVTALERHGI PVDLIGGTSI GSFVGGLYAK DYNIVSIYGR AKKFSKRVSS
1210 1220 1230 1240 1250
VWRMIFDLTY PVTSYITGYE FNRGIWKVFG FTEIEDFWIK YFCNSTNITN
1260 1270 1280 1290 1300
STMDIHESGY AWRFIRASMS LAGLLPPIAF KGCMLLDGGY LDNLPVMEMK
1310 1320 1330 1340 1350
RRGAKHIFAV DVGSVDDRTP MDYGDTLSGF WVVFNKWNPF SKHPNVPNMM
1360 1370 1380 1390 1400
DIQLRLAYVA SVNALEEAKR TPGVYYLRPP IDNYATLDFG KFDEIYQVGL
1410 1420 1430 1440
GYADKLFTEW ENKKQLPEIA GFVKRDGMQN GGERIKMYRR NTM
Length:1,443
Mass (Da):161,900
Last modified:June 12, 2007 - v1
Checksum:i339E4C844D414585
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981532 Genomic DNA. Translation: EDK47216.1.
RefSeqiXP_001523551.1. XM_001523501.1.

Genome annotation databases

GeneIDi5230489.
KEGGilel:LELG_05397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981532 Genomic DNA. Translation: EDK47216.1.
RefSeqiXP_001523551.1. XM_001523501.1.

3D structure databases

ProteinModelPortaliA5E708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36914.A5E708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5230489.
KEGGilel:LELG_05397.

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiA5E708.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry nameiNTE1_LODEL
AccessioniPrimary (citable) accession number: A5E708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.