A5E598 (KAD1_LODEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 1
Short name=AK 1
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 1
Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	LELG_04787

Organism

Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) [Complete proteome]

Taxonomic identifier

379508 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Lodderomyces

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Adenylate kinase 1		PRO_0000365677
Regions
	Nucleotide binding	44 – 52	9	ATP By similarity
	Nucleotide binding	67 – 96	30	AMP By similarity
Sites
	Binding site	68	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5E598 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: C9AA5F0EEC7A9B3F	FASTA	252	28,214
	10 20 30 40 50 60 MSVEELKDTV HKLHERIQQL EKKVGVLPSS QPDFAKQLRL VLIGAPGSGK GTQSTDLKDK 70 80 90 100 110 120 FCACHLATGD MLRSQVKQGT PLGLEAKKIM DQGGLVNDEI MIGMIKQELE TNQDCKKGFI 130 140 150 160 170 180 LDGFPRTIPQ AEKLDSMLKD RKTPLENAIE LKIDDELLVD RITGRLVHPA SGRSYHKIFS 190 200 210 220 230 240 PPKKEMTDDI TGEPLVQRSD DNEAALKKRL VTYHAQTEPI VEYYKKTGIW QGIDASQKPA 250 KVWKDILKCL GQ

References

[1]

"Evolution of pathogenicity and sexual reproduction in eight Candida genomes." Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S., Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J. , Harris D., Hoyer L.L., Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D., Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T., Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C., Birren B.W., Kellis M., Cuomo C.A. Nature 459:657-662(2009) [PubMed: 19465905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH981530 Genomic DNA. Translation: EDK46606.1.
RefSeq	XP_001523974.1. XM_001523924.1.
3D structure databases
ProteinModelPortal	A5E598.
SMR	A5E598. Positions 36-252.
ModBase	Search...
Protein-protein interaction databases
STRING	A5E598.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5230965.
KEGG	lel:LELG_04787.
Phylogenomic databases
OMA	HCLCHLA.
OrthoDB	EOG4X0R28.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_LODEL

Accession

Primary (citable) accession number: A5E598

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	June 12, 2007
Last modified:	November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program