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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi593Zinc; catalyticPROSITE-ProRule annotation1
Active sitei594PROSITE-ProRule annotation1
Metal bindingi597Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi600Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:LELG_04645
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
Proteomesi
  • UP000001996 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000033858626 – 811Mitochondrial intermediate peptidaseAdd BLAST786

Proteomic databases

PRIDEiA5E4V6

Interactioni

Protein-protein interaction databases

STRINGi379508.XP_001523832.1

Structurei

3D structure databases

ProteinModelPortaliA5E4V6
SMRiA5E4V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 58Poly-Asn4
Compositional biasi431 – 444Poly-ThrAdd BLAST14
Compositional biasi447 – 452Poly-Thr6

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
InParanoidiA5E4V6
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 2 hits
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5E4V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGSRLSNY LVRLSGRVSF TQKRSLTNVK LPSNVNYERL KAAFDSDEHT
60 70 80 90 100
LNGKNNNNEG KLFSKTALFQ GQKDGSASTG LFKNSYLTSP QGLVQFSKKS
110 120 130 140 150
KLQAQTLVDE MTRDVLTHQG KLDYIKKLDQ LSDILCRTID VAEFIRVVHD
160 170 180 190 200
DQKWVDAAQQ THEIIFEYMN QLNTNVELYA NLVKILEDKD LISQLSDEEI
210 220 230 240 250
KVGEYLRQDF ERSGIHMDPQ SRDQFVSLTQ EISIMGSHFN NESSSLKSDW
260 270 280 290 300
ISITSNEFSA IEDRFIQSEV MRASALYPGK KESGTYYIPL ASAIPYRIMI
310 320 330 340 350
QCGSGNLRKK MWIGLHEASD EQVQVLNHFV AYRALLAKML GYDSYAHYQL
360 370 380 390 400
EHKMAKKPEN VLSFLTNLQE NLKNSQVLKE LRALSALQQG YSLLSDEELI
410 420 430 440 450
RQIKPWDRDF LLKSFEAKKL SSTENGEKAS TDTSTSTTTS TTTTDSTTTT
460 470 480 490 500
ATFSNSTDSV AIKRLCEYFS IGTVIAGLSK LFSALYNISF VVEPTVKGEV
510 520 530 540 550
WNEKRVRKLN VLNNSNGETM GYLYLDFCSP KVFPSHFTVV CLRQLNKAES
560 570 580 590 600
VSEHGDMVQL SKDYQLPVVA LVCNFTSGNP TLLSLDQVDT IFHEMGHAMH
610 620 630 640 650
SMIGRTQLHN LSGTRCATDF VEIPSVLMES FSKDPRVLSE IGCHYRTGEP
660 670 680 690 700
VPINLLEQAQ SQRSALEACE TFVQSKMAML DQELHSKEIV ELLRQGLEAI
710 720 730 740 750
NSTEIYHQVE RDLEIFADEW STWHGKFPHL FSYGAVYYSY LLDRAIANVL
760 770 780 790 800
WQKLFAKDPW SRDAGIKYKE EILKWGGTKD PWACLADALQ MEELRKGDAH
810
AMQIIGENSK L
Length:811
Mass (Da):91,934
Last modified:June 12, 2007 - v1
Checksum:iE9995C8F9BF12958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981530 Genomic DNA Translation: EDK46464.1
RefSeqiXP_001523832.1, XM_001523782.1

Genome annotation databases

EnsemblFungiiEDK46464; EDK46464; LELG_04645
GeneIDi5231285
KEGGilel:LELG_04645

Entry informationi

Entry nameiPMIP_LODEL
AccessioniPrimary (citable) accession number: A5E4V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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