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A5E4V6

- PMIP_LODEL

UniProt

A5E4V6 - PMIP_LODEL

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi593 – 5931Zinc; catalyticPROSITE-ProRule annotation
Active sitei594 – 5941PROSITE-ProRule annotation
Metal bindingi597 – 5971Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi600 – 6001Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:LELG_04645
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
BLAST
Chaini26 – 811786Mitochondrial intermediate peptidasePRO_0000338586Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36914.A5E4V6.

Structurei

3D structure databases

ProteinModelPortaliA5E4V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 584Poly-Asn
Compositional biasi431 – 44414Poly-ThrAdd
BLAST
Compositional biasi447 – 4526Poly-Thr

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
InParanoidiA5E4V6.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 2 hits.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5E4V6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSGSRLSNY LVRLSGRVSF TQKRSLTNVK LPSNVNYERL KAAFDSDEHT
60 70 80 90 100
LNGKNNNNEG KLFSKTALFQ GQKDGSASTG LFKNSYLTSP QGLVQFSKKS
110 120 130 140 150
KLQAQTLVDE MTRDVLTHQG KLDYIKKLDQ LSDILCRTID VAEFIRVVHD
160 170 180 190 200
DQKWVDAAQQ THEIIFEYMN QLNTNVELYA NLVKILEDKD LISQLSDEEI
210 220 230 240 250
KVGEYLRQDF ERSGIHMDPQ SRDQFVSLTQ EISIMGSHFN NESSSLKSDW
260 270 280 290 300
ISITSNEFSA IEDRFIQSEV MRASALYPGK KESGTYYIPL ASAIPYRIMI
310 320 330 340 350
QCGSGNLRKK MWIGLHEASD EQVQVLNHFV AYRALLAKML GYDSYAHYQL
360 370 380 390 400
EHKMAKKPEN VLSFLTNLQE NLKNSQVLKE LRALSALQQG YSLLSDEELI
410 420 430 440 450
RQIKPWDRDF LLKSFEAKKL SSTENGEKAS TDTSTSTTTS TTTTDSTTTT
460 470 480 490 500
ATFSNSTDSV AIKRLCEYFS IGTVIAGLSK LFSALYNISF VVEPTVKGEV
510 520 530 540 550
WNEKRVRKLN VLNNSNGETM GYLYLDFCSP KVFPSHFTVV CLRQLNKAES
560 570 580 590 600
VSEHGDMVQL SKDYQLPVVA LVCNFTSGNP TLLSLDQVDT IFHEMGHAMH
610 620 630 640 650
SMIGRTQLHN LSGTRCATDF VEIPSVLMES FSKDPRVLSE IGCHYRTGEP
660 670 680 690 700
VPINLLEQAQ SQRSALEACE TFVQSKMAML DQELHSKEIV ELLRQGLEAI
710 720 730 740 750
NSTEIYHQVE RDLEIFADEW STWHGKFPHL FSYGAVYYSY LLDRAIANVL
760 770 780 790 800
WQKLFAKDPW SRDAGIKYKE EILKWGGTKD PWACLADALQ MEELRKGDAH
810
AMQIIGENSK L
Length:811
Mass (Da):91,934
Last modified:June 12, 2007 - v1
Checksum:iE9995C8F9BF12958
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981530 Genomic DNA. Translation: EDK46464.1.
RefSeqiXP_001523832.1. XM_001523782.1.

Genome annotation databases

GeneIDi5231285.
KEGGilel:LELG_04645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981530 Genomic DNA. Translation: EDK46464.1 .
RefSeqi XP_001523832.1. XM_001523782.1.

3D structure databases

ProteinModelPortali A5E4V6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5E4V6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5231285.
KEGGi lel:LELG_04645.

Phylogenomic databases

eggNOGi COG0339.
InParanoidi A5E4V6.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 2 hits.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry nameiPMIP_LODEL
AccessioniPrimary (citable) accession number: A5E4V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3