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A5E4V6

- PMIP_LODEL

UniProt

A5E4V6 - PMIP_LODEL

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi593 – 5931Zinc; catalyticPROSITE-ProRule annotation
    Active sitei594 – 5941PROSITE-ProRule annotation
    Metal bindingi597 – 5971Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi600 – 6001Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:LELG_04645
    OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
    Taxonomic identifieri379508 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
    ProteomesiUP000001996: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
    BLAST
    Chaini26 – 811786Mitochondrial intermediate peptidasePRO_0000338586Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi36914.A5E4V6.

    Structurei

    3D structure databases

    ProteinModelPortaliA5E4V6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 584Poly-Asn
    Compositional biasi431 – 44414Poly-ThrAdd
    BLAST
    Compositional biasi447 – 4526Poly-Thr

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01410.
    OMAiLQVFYSA.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 2 hits.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5E4V6-1 [UniParc]FASTAAdd to Basket

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    MRSGSRLSNY LVRLSGRVSF TQKRSLTNVK LPSNVNYERL KAAFDSDEHT    50
    LNGKNNNNEG KLFSKTALFQ GQKDGSASTG LFKNSYLTSP QGLVQFSKKS 100
    KLQAQTLVDE MTRDVLTHQG KLDYIKKLDQ LSDILCRTID VAEFIRVVHD 150
    DQKWVDAAQQ THEIIFEYMN QLNTNVELYA NLVKILEDKD LISQLSDEEI 200
    KVGEYLRQDF ERSGIHMDPQ SRDQFVSLTQ EISIMGSHFN NESSSLKSDW 250
    ISITSNEFSA IEDRFIQSEV MRASALYPGK KESGTYYIPL ASAIPYRIMI 300
    QCGSGNLRKK MWIGLHEASD EQVQVLNHFV AYRALLAKML GYDSYAHYQL 350
    EHKMAKKPEN VLSFLTNLQE NLKNSQVLKE LRALSALQQG YSLLSDEELI 400
    RQIKPWDRDF LLKSFEAKKL SSTENGEKAS TDTSTSTTTS TTTTDSTTTT 450
    ATFSNSTDSV AIKRLCEYFS IGTVIAGLSK LFSALYNISF VVEPTVKGEV 500
    WNEKRVRKLN VLNNSNGETM GYLYLDFCSP KVFPSHFTVV CLRQLNKAES 550
    VSEHGDMVQL SKDYQLPVVA LVCNFTSGNP TLLSLDQVDT IFHEMGHAMH 600
    SMIGRTQLHN LSGTRCATDF VEIPSVLMES FSKDPRVLSE IGCHYRTGEP 650
    VPINLLEQAQ SQRSALEACE TFVQSKMAML DQELHSKEIV ELLRQGLEAI 700
    NSTEIYHQVE RDLEIFADEW STWHGKFPHL FSYGAVYYSY LLDRAIANVL 750
    WQKLFAKDPW SRDAGIKYKE EILKWGGTKD PWACLADALQ MEELRKGDAH 800
    AMQIIGENSK L 811
    Length:811
    Mass (Da):91,934
    Last modified:June 12, 2007 - v1
    Checksum:iE9995C8F9BF12958
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981530 Genomic DNA. Translation: EDK46464.1.
    RefSeqiXP_001523832.1. XM_001523782.1.

    Genome annotation databases

    GeneIDi5231285.
    KEGGilel:LELG_04645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981530 Genomic DNA. Translation: EDK46464.1 .
    RefSeqi XP_001523832.1. XM_001523782.1.

    3D structure databases

    ProteinModelPortali A5E4V6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36914.A5E4V6.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5231285.
    KEGGi lel:LELG_04645.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01410.
    OMAi LQVFYSA.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 2 hits.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

    Entry informationi

    Entry nameiPMIP_LODEL
    AccessioniPrimary (citable) accession number: A5E4V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3