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A5E4V6

- PMIP_LODEL

UniProt

A5E4V6 - PMIP_LODEL

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Protein

Mitochondrial intermediate peptidase

Gene
OCT1, LELG_04645
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi593 – 5931Zinc; catalytic By similarity
Active sitei594 – 5941 By similarity
Metal bindingi597 – 5971Zinc; catalytic By similarity
Metal bindingi600 – 6001Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:LELG_04645
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion Reviewed predictionAdd
BLAST
Chaini26 – 811786Mitochondrial intermediate peptidasePRO_0000338586Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36914.A5E4V6.

Structurei

3D structure databases

ProteinModelPortaliA5E4V6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 584Poly-Asn
Compositional biasi431 – 44414Poly-ThrAdd
BLAST
Compositional biasi447 – 4526Poly-Thr

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 2 hits.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5E4V6-1 [UniParc]FASTAAdd to Basket

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MRSGSRLSNY LVRLSGRVSF TQKRSLTNVK LPSNVNYERL KAAFDSDEHT    50
LNGKNNNNEG KLFSKTALFQ GQKDGSASTG LFKNSYLTSP QGLVQFSKKS 100
KLQAQTLVDE MTRDVLTHQG KLDYIKKLDQ LSDILCRTID VAEFIRVVHD 150
DQKWVDAAQQ THEIIFEYMN QLNTNVELYA NLVKILEDKD LISQLSDEEI 200
KVGEYLRQDF ERSGIHMDPQ SRDQFVSLTQ EISIMGSHFN NESSSLKSDW 250
ISITSNEFSA IEDRFIQSEV MRASALYPGK KESGTYYIPL ASAIPYRIMI 300
QCGSGNLRKK MWIGLHEASD EQVQVLNHFV AYRALLAKML GYDSYAHYQL 350
EHKMAKKPEN VLSFLTNLQE NLKNSQVLKE LRALSALQQG YSLLSDEELI 400
RQIKPWDRDF LLKSFEAKKL SSTENGEKAS TDTSTSTTTS TTTTDSTTTT 450
ATFSNSTDSV AIKRLCEYFS IGTVIAGLSK LFSALYNISF VVEPTVKGEV 500
WNEKRVRKLN VLNNSNGETM GYLYLDFCSP KVFPSHFTVV CLRQLNKAES 550
VSEHGDMVQL SKDYQLPVVA LVCNFTSGNP TLLSLDQVDT IFHEMGHAMH 600
SMIGRTQLHN LSGTRCATDF VEIPSVLMES FSKDPRVLSE IGCHYRTGEP 650
VPINLLEQAQ SQRSALEACE TFVQSKMAML DQELHSKEIV ELLRQGLEAI 700
NSTEIYHQVE RDLEIFADEW STWHGKFPHL FSYGAVYYSY LLDRAIANVL 750
WQKLFAKDPW SRDAGIKYKE EILKWGGTKD PWACLADALQ MEELRKGDAH 800
AMQIIGENSK L 811
Length:811
Mass (Da):91,934
Last modified:June 12, 2007 - v1
Checksum:iE9995C8F9BF12958
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981530 Genomic DNA. Translation: EDK46464.1.
RefSeqiXP_001523832.1. XM_001523782.1.

Genome annotation databases

GeneIDi5231285.
KEGGilel:LELG_04645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981530 Genomic DNA. Translation: EDK46464.1 .
RefSeqi XP_001523832.1. XM_001523782.1.

3D structure databases

ProteinModelPortali A5E4V6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5E4V6.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5231285.
KEGGi lel:LELG_04645.

Phylogenomic databases

eggNOGi COG0339.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 2 hits.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry nameiPMIP_LODEL
AccessioniPrimary (citable) accession number: A5E4V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3