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A5E357 (A5E357_LODEL) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site551Substrate By similarity PIRSR PIRSR001109-1
Binding site1311Substrate By similarity PIRSR PIRSR001109-1
Binding site1561Substrate By similarity PIRSR PIRSR001109-1
Binding site1861Substrate By similarity PIRSR PIRSR001109-1
Binding site1901Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
A5E357 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 792EDCADF4D9DB0D

FASTA44648,823
        10         20         30         40         50         60 
MASNYKVADI SLAAFGRKDI ELSENEMPGL MYIRKKYGPS QPLKGARIAG CLHMTIQTAV 

        70         80         90        100        110        120 
LIETLVALGA EVTWTSCNIF STQDHAAAAI AAAGVPVFAW KGETEEEYQW CIEQQLFAFK 

       130        140        150        160        170        180 
DGKKLNLILD DGGDLTSLVH EKYPEMLEDC YGLSEETTTG VHHLYKALRD GKLKVPAINV 

       190        200        210        220        230        240 
NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG FGDVGKGCAM ALQGMGARVI 

       250        260        270        280        290        300 
VTEIDPINAL QAAVSGYQVA PLDEVASIGQ IFVTTTGCRD IIVGKHFEKM PEDAIVCNIG 

       310        320        330        340        350        360 
HFDIEIDVAW LKANAESVVN IKPQVDRYLM KNGRHIILLA DGRLVNLGCA TGHSSFVMSC 

       370        380        390        400        410        420 
SFSNQVLAQI ALFNDKNKEF KEKFPEFAKT GPFDVNVHLL PKILDETVAK CHLDHLNARL 

       430        440 
TTLTDVQAEY LGIPKEGPFK ADIYRY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH981528 Genomic DNA. Translation: EDK45865.1.
RefSeqXP_001525012.1. XM_001524962.1.

3D structure databases

ProteinModelPortalA5E357.
SMRA5E357. Positions 5-446.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5E357.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5231904.
KEGGlel:LELG_04044.

Phylogenomic databases

OMASAQVWVT.
OrthoDBEOG41G6CK.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5E357_LODEL
AccessionPrimary (citable) accession number: A5E357
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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