A5E357 (A5E357_LODEL) Unreviewed, UniProtKB/TrEMBL
Last modified
April 3, 2013.
Version 50.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize orderNames and origin
| Protein names | Recommended name: Adenosylhomocysteinase RuleBase RU000548 EC=3.3.1.1 RuleBase RU000548 | ||
| Gene names |
| ||
| Organism | Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) [Complete proteome] EMBL EDK45865.1 | ||
| Taxonomic identifier | 379508 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Lodderomyces › ![]() |
Protein attributes
| Sequence length | 446 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548 |
| Cofactor | Binds 1 NAD per subunit By similarity. RuleBase RU000548 |
| Pathway | Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548 |
| Sequence similarities | Belongs to the adenosylhomocysteinase family. RuleBase RU004166 |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism RuleBase RU000548 |
| Ligand | NAD RuleBase RU000548 |
| Molecular function | Hydrolase RuleBase RU000548 |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular_function | adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Sites | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Binding site | 55 | 1 | Substrate By similarity PIRSR PIRSR001109-1 | ||||||
| Binding site | 131 | 1 | Substrate By similarity PIRSR PIRSR001109-1 | ||||||
| Binding site | 156 | 1 | Substrate By similarity PIRSR PIRSR001109-1 | ||||||
| Binding site | 186 | 1 | Substrate By similarity PIRSR PIRSR001109-1 | ||||||
| Binding site | 190 | 1 | Substrate By similarity PIRSR PIRSR001109-1 | ||||||
Sequences
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References
| [1] | "Evolution of pathogenicity and sexual reproduction in eight Candida genomes." Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S., Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J. Cuomo C.A.Nature 459:657-662(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CH981528 Genomic DNA. Translation: EDK45865.1. |
| RefSeq | XP_001525012.1. XM_001524962.1. |
3D structure databases | |
| ProteinModelPortal | A5E357. |
| SMR | A5E357. Positions 5-446. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 36914.A5E357. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5231904. |
| KEGG | lel:LELG_04044. |
Phylogenomic databases | |
| KO | K01251. |
| OMA | TIGMALH. |
| OrthoDB | EOG41G6CK. |
Enzyme and pathway databases | |
| UniPathway | UPA00314; UER00076. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| HAMAP | MF_00563. AdoHcyase. |
| InterPro | IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR016040. NAD(P)-bd_dom. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view] |
| PANTHER | PTHR23420. PTHR23420. 1 hit. |
| Pfam | PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view] |
| PIRSF | PIRSF001109. Ad_hcy_hydrolase. 1 hit. |
| SMART | SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00936. ahcY. 1 hit. |
| PROSITE | PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | A5E357_LODEL | ||||||||
| Accession | Primary (citable) accession number: A5E357 | ||||||||
| Entry history |
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| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||

Clusters with
