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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45DioxygenUniRule annotation1
Metal bindingi49Iron; catalyticUniRule annotation1
Metal bindingi55Iron; catalyticUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi93Iron; catalyticUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei107SubstrateUniRule annotation1
Metal bindingi122Divalent metal cationUniRule annotation1
Metal bindingi125Divalent metal cationUniRule annotation1
Metal bindingi159Divalent metal cationUniRule annotation1
Metal bindingi162Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
ORF Names:LELG_03286
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
Proteomesi
  • UP000001996 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003619881 – 1753-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST175

Proteomic databases

PRIDEiA5E0Z9

Interactioni

Protein-protein interaction databases

STRINGi379508.XP_001525358.1

Structurei

3D structure databases

ProteinModelPortaliA5E0Z9
SMRiA5E0Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3995 Eukaryota
ENOG4111GH8 LUCA
InParanoidiA5E0Z9
KOiK00452
OMAiNARKDYH
OrthoDBiEOG092C5CUF

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00825 3_HAO, 1 hit
InterProiView protein in InterPro
IPR010329 3hydroanth_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR15497 PTHR15497, 1 hit
PfamiView protein in Pfam
PF06052 3-HAO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR03037 anthran_nbaC, 1 hit

Sequencei

Sequence statusi: Complete.

A5E0Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPEPLNIK AWVEENEHLL KPPVNNFCLH RGGFTVMIVG GPNERSDYHI
60 70 80 90 100
NQTPEYFYQY KGTMCLKVVD EGKFRDIYIR EGDTFLLPPN VPHNPCRFEN
110 120 130 140 150
TVGIVVEQDR PKGVNDRIRW YCARCESIVC EEEFYLTDLG TQIKDAIVAF
160 170
DSNIEAKTCK NCGHVNSSKR EPAEF
Length:175
Mass (Da):20,157
Last modified:June 12, 2007 - v1
Checksum:i6ABC58FEBA0680A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981527 Genomic DNA Translation: EDK45107.1
RefSeqiXP_001525358.1, XM_001525308.1

Genome annotation databases

EnsemblFungiiEDK45107; EDK45107; LELG_03286
GeneIDi5232567
KEGGilel:LELG_03286

Similar proteinsi

Entry informationi

Entry namei3HAO_LODEL
AccessioniPrimary (citable) accession number: A5E0Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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