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A5E0Z9

- 3HAO_LODEL

UniProt

A5E0Z9 - 3HAO_LODEL

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451DioxygenUniRule annotation
Metal bindingi49 – 491Iron; catalyticUniRule annotation
Metal bindingi55 – 551Iron; catalyticUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Metal bindingi93 – 931Iron; catalyticUniRule annotation
Binding sitei97 – 971SubstrateUniRule annotation
Binding sitei107 – 1071SubstrateUniRule annotation
Metal bindingi122 – 1221Divalent metal cationUniRule annotation
Metal bindingi125 – 1251Divalent metal cationUniRule annotation
Metal bindingi159 – 1591Divalent metal cationUniRule annotation
Metal bindingi162 – 1621Divalent metal cationUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
ORF Names:LELG_03286
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1751753-hydroxyanthranilate 3,4-dioxygenasePRO_0000361988Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36914.A5E0Z9.

Structurei

3D structure databases

ProteinModelPortaliA5E0Z9.
SMRiA5E0Z9. Positions 6-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
InParanoidiA5E0Z9.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG7QK0Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

A5E0Z9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLPEPLNIK AWVEENEHLL KPPVNNFCLH RGGFTVMIVG GPNERSDYHI
60 70 80 90 100
NQTPEYFYQY KGTMCLKVVD EGKFRDIYIR EGDTFLLPPN VPHNPCRFEN
110 120 130 140 150
TVGIVVEQDR PKGVNDRIRW YCARCESIVC EEEFYLTDLG TQIKDAIVAF
160 170
DSNIEAKTCK NCGHVNSSKR EPAEF
Length:175
Mass (Da):20,157
Last modified:June 12, 2007 - v1
Checksum:i6ABC58FEBA0680A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981527 Genomic DNA. Translation: EDK45107.1.
RefSeqiXP_001525358.1. XM_001525308.1.

Genome annotation databases

GeneIDi5232567.
KEGGilel:LELG_03286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981527 Genomic DNA. Translation: EDK45107.1 .
RefSeqi XP_001525358.1. XM_001525308.1.

3D structure databases

ProteinModelPortali A5E0Z9.
SMRi A5E0Z9. Positions 6-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5E0Z9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5232567.
KEGGi lel:LELG_03286.

Phylogenomic databases

eggNOGi NOG77058.
InParanoidi A5E0Z9.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG7QK0Q0.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry namei3HAO_LODEL
AccessioniPrimary (citable) accession number: A5E0Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 12, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3