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A5DVI3

- A5DVI3_LODEL

UniProt

A5DVI3 - A5DVI3_LODEL

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

LELG_01369

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:LELG_01369Imported
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)Imported
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi36914.A5DVI3.

Structurei

3D structure databases

ProteinModelPortaliA5DVI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

InParanoidiA5DVI3.
KOiK11422.
OMAiCGAPGCK.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DVI3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYGESYRSR GYRGDRGAGY YGDSSYRKPH SQRDDHGSSR SRLDDTRRNY
60 70 80 90 100
SPSSGSGGFP SDGFNRRYAN KGRGSTYEKE DWSYRDKRRW HHSGAGVGAS
110 120 130 140 150
GALANTSGKA TPLTNTSDRN SLDAVYSGTD TKTGVNRTDL EFTKLAHHTD
160 170 180 190 200
FTNAITILNT DSSTPNNSSS SSSSSSNSKN YKVLYDPELD TSLSKAERKM
210 220 230 240 250
KSKKLRFNGE GVPTDQLVDP RIANLSHYLL KPNKKSSKFP FKQLPQARFI
260 270 280 290 300
YDSDSLGPAP LTTLVIWDLP ISVNMQYLKN YLGTYGLIEN IEIINDPNTA
310 320 330 340 350
VPLGVATFRF KGTPEKSSDL ATKFVERVKI ELIKINGIAL KIGLNDSEDT
360 370 380 390 400
LLNQKVNIAR GKIINQRLKR EQEEEKRRLK LQEEQKKQEE IAKKEAEIKK
410 420 430 440 450
QQEIEEAKRR AAELKYKPNT TLLSSRHDHK VEEGVFLPNE LTKYIKNRPY
460 470 480 490 500
LLIRDKYVPT KKVSSQEIKR TLKKYDWTRV LSDKTGYYVV FNSLKECIKC
510 520 530 540 550
FEQEDCRKLF EFRLVMELAV PEGFEESQRG NDEADNDIIE EASNVLIKEF
560 570 580 590 600
ESFLVKDIRE RIIAPHILKL LDHSHYPALV EELKAKEQQE AKAKIAATSN
610 620 630 640 650
ASLKLNALSL LEKQKQNLKP KTKYFKQVED RFGSRKHGKK GAIIPMQHAL
660 670 680 690 700
NDDDDDDDDH EDEDDDNDGE GASSDEDEIT SGSTTPMVRE PLKRVHSSSA
710 720 730 740 750
TSIVDEFEVG EPERKKHKKL RKEMSTESDD EMESISGKNE EDTEDVKRDK
760 770 780 790 800
KEEEEEEEAE KKEKSTEEQE PMDAEMDDVD QMSLDSKYRP TEKRPRTVYP
810 820 830 840 850
ETTIPDTVDL RCLQEFIKDA EDLKFAQSIL GDVDVMESDV PVLKNIEYWA
860 870 880 890 900
WKQGKNTNES EEIVERDEGF IDDEQEAEEI EEEPEEELPA HLESASGCFK
910 920 930 940 950
SEGYKKIPDE DKNHYLPHRK RADKFIKTVQ YEEDDDEKAT EGSHSNNNSN
960 970 980 990 1000
SNNSNSINNG SSSTTTNNSN SNTNAAQSSR VNRANNRRFA ADITAQIGTE
1010 1020 1030 1040 1050
SDVLSLNALT KRKKPVTFAR SSIHNWGLYA MEPIAAKEMI IEYVGERIRQ
1060 1070 1080 1090 1100
QVAEHREKSY LRTGIGSSYL FRIDENTVID ATKKGGIARF INHCCSPSCT
1110 1120 1130 1140 1150
AKIIKVDGKK RIVIYALRDI EANEELTYDY KFERETNDDE RIRCLCGAPG

CKGFLN
Length:1,156
Mass (Da):131,572
Last modified:June 12, 2007 - v1
Checksum:i51B9D9B9DFE0543A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981525 Genomic DNA. Translation: EDK43191.1.
RefSeqiXP_001526541.1. XM_001526491.1.

Genome annotation databases

GeneIDi5234168.
KEGGilel:LELG_01369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981525 Genomic DNA. Translation: EDK43191.1 .
RefSeqi XP_001526541.1. XM_001526491.1.

3D structure databases

ProteinModelPortali A5DVI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5DVI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5234168.
KEGGi lel:LELG_01369.

Phylogenomic databases

InParanoidi A5DVI3.
KOi K11422.
OMAi CGAPGCK.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239Imported.

Entry informationi

Entry nameiA5DVI3_LODEL
AccessioniPrimary (citable) accession number: A5DVI3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3