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A5DVI3

- A5DVI3_LODEL

UniProt

A5DVI3 - A5DVI3_LODEL

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Protein
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Gene
LELG_01369
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:LELG_01369Imported
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)Imported
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
ProteomesiUP000001996: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. Set1C/COMPASS complex Source: InterPro
  2. chromosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi36914.A5DVI3.

Structurei

3D structure databases

ProteinModelPortaliA5DVI3.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Phylogenomic databases

KOiK11422.
OMAiCGAPGCK.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DVI3-1 [UniParc]FASTAAdd to Basket

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MAYGESYRSR GYRGDRGAGY YGDSSYRKPH SQRDDHGSSR SRLDDTRRNY     50
SPSSGSGGFP SDGFNRRYAN KGRGSTYEKE DWSYRDKRRW HHSGAGVGAS 100
GALANTSGKA TPLTNTSDRN SLDAVYSGTD TKTGVNRTDL EFTKLAHHTD 150
FTNAITILNT DSSTPNNSSS SSSSSSNSKN YKVLYDPELD TSLSKAERKM 200
KSKKLRFNGE GVPTDQLVDP RIANLSHYLL KPNKKSSKFP FKQLPQARFI 250
YDSDSLGPAP LTTLVIWDLP ISVNMQYLKN YLGTYGLIEN IEIINDPNTA 300
VPLGVATFRF KGTPEKSSDL ATKFVERVKI ELIKINGIAL KIGLNDSEDT 350
LLNQKVNIAR GKIINQRLKR EQEEEKRRLK LQEEQKKQEE IAKKEAEIKK 400
QQEIEEAKRR AAELKYKPNT TLLSSRHDHK VEEGVFLPNE LTKYIKNRPY 450
LLIRDKYVPT KKVSSQEIKR TLKKYDWTRV LSDKTGYYVV FNSLKECIKC 500
FEQEDCRKLF EFRLVMELAV PEGFEESQRG NDEADNDIIE EASNVLIKEF 550
ESFLVKDIRE RIIAPHILKL LDHSHYPALV EELKAKEQQE AKAKIAATSN 600
ASLKLNALSL LEKQKQNLKP KTKYFKQVED RFGSRKHGKK GAIIPMQHAL 650
NDDDDDDDDH EDEDDDNDGE GASSDEDEIT SGSTTPMVRE PLKRVHSSSA 700
TSIVDEFEVG EPERKKHKKL RKEMSTESDD EMESISGKNE EDTEDVKRDK 750
KEEEEEEEAE KKEKSTEEQE PMDAEMDDVD QMSLDSKYRP TEKRPRTVYP 800
ETTIPDTVDL RCLQEFIKDA EDLKFAQSIL GDVDVMESDV PVLKNIEYWA 850
WKQGKNTNES EEIVERDEGF IDDEQEAEEI EEEPEEELPA HLESASGCFK 900
SEGYKKIPDE DKNHYLPHRK RADKFIKTVQ YEEDDDEKAT EGSHSNNNSN 950
SNNSNSINNG SSSTTTNNSN SNTNAAQSSR VNRANNRRFA ADITAQIGTE 1000
SDVLSLNALT KRKKPVTFAR SSIHNWGLYA MEPIAAKEMI IEYVGERIRQ 1050
QVAEHREKSY LRTGIGSSYL FRIDENTVID ATKKGGIARF INHCCSPSCT 1100
AKIIKVDGKK RIVIYALRDI EANEELTYDY KFERETNDDE RIRCLCGAPG 1150
CKGFLN 1156
Length:1,156
Mass (Da):131,572
Last modified:June 12, 2007 - v1
Checksum:i51B9D9B9DFE0543A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981525 Genomic DNA. Translation: EDK43191.1.
RefSeqiXP_001526541.1. XM_001526491.1.

Genome annotation databases

GeneIDi5234168.
KEGGilel:LELG_01369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH981525 Genomic DNA. Translation: EDK43191.1 .
RefSeqi XP_001526541.1. XM_001526491.1.

3D structure databases

ProteinModelPortali A5DVI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36914.A5DVI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5234168.
KEGGi lel:LELG_01369.

Phylogenomic databases

KOi K11422.
OMAi CGAPGCK.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239.

Entry informationi

Entry nameiA5DVI3_LODEL
AccessioniPrimary (citable) accession number: A5DVI3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3