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A5DVI3 (A5DVI3_LODEL) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1156 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity. PIRNR PIRNR037104

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037104 SAAS SAAS001214

Subunit structure

Component of the COMPASS (Set1C) complex By similarity. PIRNR PIRNR037104

Subcellular location

Nucleus By similarity PIRNR PIRNR037104.

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains SET domain.

Contains post-SET domain. SAAS SAAS001214

Sequences

Sequence LengthMass (Da)Tools
A5DVI3 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 51B9D9B9DFE0543A

FASTA1,156131,572
        10         20         30         40         50         60 
MAYGESYRSR GYRGDRGAGY YGDSSYRKPH SQRDDHGSSR SRLDDTRRNY SPSSGSGGFP 

        70         80         90        100        110        120 
SDGFNRRYAN KGRGSTYEKE DWSYRDKRRW HHSGAGVGAS GALANTSGKA TPLTNTSDRN 

       130        140        150        160        170        180 
SLDAVYSGTD TKTGVNRTDL EFTKLAHHTD FTNAITILNT DSSTPNNSSS SSSSSSNSKN 

       190        200        210        220        230        240 
YKVLYDPELD TSLSKAERKM KSKKLRFNGE GVPTDQLVDP RIANLSHYLL KPNKKSSKFP 

       250        260        270        280        290        300 
FKQLPQARFI YDSDSLGPAP LTTLVIWDLP ISVNMQYLKN YLGTYGLIEN IEIINDPNTA 

       310        320        330        340        350        360 
VPLGVATFRF KGTPEKSSDL ATKFVERVKI ELIKINGIAL KIGLNDSEDT LLNQKVNIAR 

       370        380        390        400        410        420 
GKIINQRLKR EQEEEKRRLK LQEEQKKQEE IAKKEAEIKK QQEIEEAKRR AAELKYKPNT 

       430        440        450        460        470        480 
TLLSSRHDHK VEEGVFLPNE LTKYIKNRPY LLIRDKYVPT KKVSSQEIKR TLKKYDWTRV 

       490        500        510        520        530        540 
LSDKTGYYVV FNSLKECIKC FEQEDCRKLF EFRLVMELAV PEGFEESQRG NDEADNDIIE 

       550        560        570        580        590        600 
EASNVLIKEF ESFLVKDIRE RIIAPHILKL LDHSHYPALV EELKAKEQQE AKAKIAATSN 

       610        620        630        640        650        660 
ASLKLNALSL LEKQKQNLKP KTKYFKQVED RFGSRKHGKK GAIIPMQHAL NDDDDDDDDH 

       670        680        690        700        710        720 
EDEDDDNDGE GASSDEDEIT SGSTTPMVRE PLKRVHSSSA TSIVDEFEVG EPERKKHKKL 

       730        740        750        760        770        780 
RKEMSTESDD EMESISGKNE EDTEDVKRDK KEEEEEEEAE KKEKSTEEQE PMDAEMDDVD 

       790        800        810        820        830        840 
QMSLDSKYRP TEKRPRTVYP ETTIPDTVDL RCLQEFIKDA EDLKFAQSIL GDVDVMESDV 

       850        860        870        880        890        900 
PVLKNIEYWA WKQGKNTNES EEIVERDEGF IDDEQEAEEI EEEPEEELPA HLESASGCFK 

       910        920        930        940        950        960 
SEGYKKIPDE DKNHYLPHRK RADKFIKTVQ YEEDDDEKAT EGSHSNNNSN SNNSNSINNG 

       970        980        990       1000       1010       1020 
SSSTTTNNSN SNTNAAQSSR VNRANNRRFA ADITAQIGTE SDVLSLNALT KRKKPVTFAR 

      1030       1040       1050       1060       1070       1080 
SSIHNWGLYA MEPIAAKEMI IEYVGERIRQ QVAEHREKSY LRTGIGSSYL FRIDENTVID 

      1090       1100       1110       1120       1130       1140 
ATKKGGIARF INHCCSPSCT AKIIKVDGKK RIVIYALRDI EANEELTYDY KFERETNDDE 

      1150 
RIRCLCGAPG CKGFLN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH981525 Genomic DNA. Translation: EDK43191.1.
RefSeqXP_001526541.1. XM_001526491.1.

3D structure databases

ProteinModelPortalA5DVI3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36914.A5DVI3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5234168.
KEGGlel:LELG_01369.

Phylogenomic databases

KOK11422.
OMACGAPGCK.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5DVI3_LODEL
AccessionPrimary (citable) accession number: A5DVI3
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: March 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)