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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

LELG_01369

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:LELG_01369Imported
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)Imported
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
Proteomesi
  • UP000001996 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi379508.XP_001526541.1.

Structurei

3D structure databases

ProteinModelPortaliA5DVI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 347RRM (RNA recognition motif)InterPro annotationAdd BLAST86
Domaini1014 – 1131SETInterPro annotationAdd BLAST118
Domaini1140 – 1156Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili365 – 417Sequence analysisAdd BLAST53
Coiled coili739 – 770Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.SAAS annotation
Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1080. Eukaryota.
COG2940. LUCA.
InParanoidiA5DVI3.
KOiK11422.
OMAiCGAPGCK.
OrthoDBiEOG092C3T9B.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM01291. N-SET. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DVI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYGESYRSR GYRGDRGAGY YGDSSYRKPH SQRDDHGSSR SRLDDTRRNY
60 70 80 90 100
SPSSGSGGFP SDGFNRRYAN KGRGSTYEKE DWSYRDKRRW HHSGAGVGAS
110 120 130 140 150
GALANTSGKA TPLTNTSDRN SLDAVYSGTD TKTGVNRTDL EFTKLAHHTD
160 170 180 190 200
FTNAITILNT DSSTPNNSSS SSSSSSNSKN YKVLYDPELD TSLSKAERKM
210 220 230 240 250
KSKKLRFNGE GVPTDQLVDP RIANLSHYLL KPNKKSSKFP FKQLPQARFI
260 270 280 290 300
YDSDSLGPAP LTTLVIWDLP ISVNMQYLKN YLGTYGLIEN IEIINDPNTA
310 320 330 340 350
VPLGVATFRF KGTPEKSSDL ATKFVERVKI ELIKINGIAL KIGLNDSEDT
360 370 380 390 400
LLNQKVNIAR GKIINQRLKR EQEEEKRRLK LQEEQKKQEE IAKKEAEIKK
410 420 430 440 450
QQEIEEAKRR AAELKYKPNT TLLSSRHDHK VEEGVFLPNE LTKYIKNRPY
460 470 480 490 500
LLIRDKYVPT KKVSSQEIKR TLKKYDWTRV LSDKTGYYVV FNSLKECIKC
510 520 530 540 550
FEQEDCRKLF EFRLVMELAV PEGFEESQRG NDEADNDIIE EASNVLIKEF
560 570 580 590 600
ESFLVKDIRE RIIAPHILKL LDHSHYPALV EELKAKEQQE AKAKIAATSN
610 620 630 640 650
ASLKLNALSL LEKQKQNLKP KTKYFKQVED RFGSRKHGKK GAIIPMQHAL
660 670 680 690 700
NDDDDDDDDH EDEDDDNDGE GASSDEDEIT SGSTTPMVRE PLKRVHSSSA
710 720 730 740 750
TSIVDEFEVG EPERKKHKKL RKEMSTESDD EMESISGKNE EDTEDVKRDK
760 770 780 790 800
KEEEEEEEAE KKEKSTEEQE PMDAEMDDVD QMSLDSKYRP TEKRPRTVYP
810 820 830 840 850
ETTIPDTVDL RCLQEFIKDA EDLKFAQSIL GDVDVMESDV PVLKNIEYWA
860 870 880 890 900
WKQGKNTNES EEIVERDEGF IDDEQEAEEI EEEPEEELPA HLESASGCFK
910 920 930 940 950
SEGYKKIPDE DKNHYLPHRK RADKFIKTVQ YEEDDDEKAT EGSHSNNNSN
960 970 980 990 1000
SNNSNSINNG SSSTTTNNSN SNTNAAQSSR VNRANNRRFA ADITAQIGTE
1010 1020 1030 1040 1050
SDVLSLNALT KRKKPVTFAR SSIHNWGLYA MEPIAAKEMI IEYVGERIRQ
1060 1070 1080 1090 1100
QVAEHREKSY LRTGIGSSYL FRIDENTVID ATKKGGIARF INHCCSPSCT
1110 1120 1130 1140 1150
AKIIKVDGKK RIVIYALRDI EANEELTYDY KFERETNDDE RIRCLCGAPG

CKGFLN
Length:1,156
Mass (Da):131,572
Last modified:June 12, 2007 - v1
Checksum:i51B9D9B9DFE0543A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981525 Genomic DNA. Translation: EDK43191.1.
RefSeqiXP_001526541.1. XM_001526491.1.

Genome annotation databases

EnsemblFungiiEDK43191; EDK43191; LELG_01369.
GeneIDi5234168.
KEGGilel:LELG_01369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981525 Genomic DNA. Translation: EDK43191.1.
RefSeqiXP_001526541.1. XM_001526491.1.

3D structure databases

ProteinModelPortaliA5DVI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi379508.XP_001526541.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDK43191; EDK43191; LELG_01369.
GeneIDi5234168.
KEGGilel:LELG_01369.

Phylogenomic databases

eggNOGiKOG1080. Eukaryota.
COG2940. LUCA.
InParanoidiA5DVI3.
KOiK11422.
OMAiCGAPGCK.
OrthoDBiEOG092C3T9B.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM01291. N-SET. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA5DVI3_LODEL
AccessioniPrimary (citable) accession number: A5DVI3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.