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A5DVI3

- A5DVI3_LODEL

UniProt

A5DVI3 - A5DVI3_LODEL

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

LELG_01369

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    ORF Names:LELG_01369Imported
    OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)Imported
    Taxonomic identifieri379508 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeLodderomyces
    ProteomesiUP000001996: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi36914.A5DVI3.

    Structurei

    3D structure databases

    ProteinModelPortaliA5DVI3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    KOiK11422.
    OMAiCGAPGCK.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5DVI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYGESYRSR GYRGDRGAGY YGDSSYRKPH SQRDDHGSSR SRLDDTRRNY     50
    SPSSGSGGFP SDGFNRRYAN KGRGSTYEKE DWSYRDKRRW HHSGAGVGAS 100
    GALANTSGKA TPLTNTSDRN SLDAVYSGTD TKTGVNRTDL EFTKLAHHTD 150
    FTNAITILNT DSSTPNNSSS SSSSSSNSKN YKVLYDPELD TSLSKAERKM 200
    KSKKLRFNGE GVPTDQLVDP RIANLSHYLL KPNKKSSKFP FKQLPQARFI 250
    YDSDSLGPAP LTTLVIWDLP ISVNMQYLKN YLGTYGLIEN IEIINDPNTA 300
    VPLGVATFRF KGTPEKSSDL ATKFVERVKI ELIKINGIAL KIGLNDSEDT 350
    LLNQKVNIAR GKIINQRLKR EQEEEKRRLK LQEEQKKQEE IAKKEAEIKK 400
    QQEIEEAKRR AAELKYKPNT TLLSSRHDHK VEEGVFLPNE LTKYIKNRPY 450
    LLIRDKYVPT KKVSSQEIKR TLKKYDWTRV LSDKTGYYVV FNSLKECIKC 500
    FEQEDCRKLF EFRLVMELAV PEGFEESQRG NDEADNDIIE EASNVLIKEF 550
    ESFLVKDIRE RIIAPHILKL LDHSHYPALV EELKAKEQQE AKAKIAATSN 600
    ASLKLNALSL LEKQKQNLKP KTKYFKQVED RFGSRKHGKK GAIIPMQHAL 650
    NDDDDDDDDH EDEDDDNDGE GASSDEDEIT SGSTTPMVRE PLKRVHSSSA 700
    TSIVDEFEVG EPERKKHKKL RKEMSTESDD EMESISGKNE EDTEDVKRDK 750
    KEEEEEEEAE KKEKSTEEQE PMDAEMDDVD QMSLDSKYRP TEKRPRTVYP 800
    ETTIPDTVDL RCLQEFIKDA EDLKFAQSIL GDVDVMESDV PVLKNIEYWA 850
    WKQGKNTNES EEIVERDEGF IDDEQEAEEI EEEPEEELPA HLESASGCFK 900
    SEGYKKIPDE DKNHYLPHRK RADKFIKTVQ YEEDDDEKAT EGSHSNNNSN 950
    SNNSNSINNG SSSTTTNNSN SNTNAAQSSR VNRANNRRFA ADITAQIGTE 1000
    SDVLSLNALT KRKKPVTFAR SSIHNWGLYA MEPIAAKEMI IEYVGERIRQ 1050
    QVAEHREKSY LRTGIGSSYL FRIDENTVID ATKKGGIARF INHCCSPSCT 1100
    AKIIKVDGKK RIVIYALRDI EANEELTYDY KFERETNDDE RIRCLCGAPG 1150
    CKGFLN 1156
    Length:1,156
    Mass (Da):131,572
    Last modified:June 12, 2007 - v1
    Checksum:i51B9D9B9DFE0543A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981525 Genomic DNA. Translation: EDK43191.1.
    RefSeqiXP_001526541.1. XM_001526491.1.

    Genome annotation databases

    GeneIDi5234168.
    KEGGilel:LELG_01369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH981525 Genomic DNA. Translation: EDK43191.1 .
    RefSeqi XP_001526541.1. XM_001526491.1.

    3D structure databases

    ProteinModelPortali A5DVI3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36914.A5DVI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5234168.
    KEGGi lel:LELG_01369.

    Phylogenomic databases

    KOi K11422.
    OMAi CGAPGCK.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239Imported.

    Entry informationi

    Entry nameiA5DVI3_LODEL
    AccessioniPrimary (citable) accession number: A5DVI3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3