ID   GSM1_PICGU              Reviewed;         520 AA.
AC   A5DRJ2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Glucose starvation modulator protein 1;
GN   Name=GSM1; ORFNames=PGUG_05893;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408162; EDK41795.2; -; Genomic_DNA.
DR   RefSeq; XP_001482130.1; XM_001482080.1.
DR   AlphaFoldDB; A5DRJ2; -.
DR   GeneID; 5123950; -.
DR   KEGG; pgu:PGUG_05893; -.
DR   VEuPathDB; FungiDB:PGUG_05893; -.
DR   eggNOG; ENOG502R2ZP; Eukaryota.
DR   HOGENOM; CLU_010748_2_2_1; -.
DR   InParanoid; A5DRJ2; -.
DR   OMA; FCHEKHL; -.
DR   OrthoDB; 5483783at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   InterPro; IPR001138; Zn2Cys6_DnaBD.
DR   PANTHER; PTHR47659:SF1; TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1; 1.
DR   PANTHER; PTHR47659; ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..520
FT                   /note="Glucose starvation modulator protein 1"
FT                   /id="PRO_0000406488"
FT   DOMAIN          376..445
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        20..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          63..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  59038 MW;  D996B569CABA4CF0 CRC64;
     MTKKLSPLEK QARRPASRAC SFCHSKHLQC SNNRPCKNCV KRNIADQCRD VERKRANYMT
     LAAKNKQGSP NTVSLESSSS PFSPLHKGHI NSQSSQPLDP SSGRVNTDFF SQSETTVPSP
     WPMDLESKER TNAILNTTDD VLNKILYDEQ ASKVPSAQAS EMTPSNSSID GVFNSNYLNQ
     EYLMLGDIIL NSKPASPTPS STSEYQTIPP NEMMGTVDYN EVYRDTKSKK LKESRPFISL
     GFSNPPDLDN RKLPGEINIA NEIMDPSKRA QVTTTNDYVS PLVTRHIYQS VQDIYANKII
     NYEYPTSYHA LTFFLKKRFS GTSLPPEQKQ QKRNNLLIIL KLIASYRPTF ISAHKSLLKP
     YDLMFLEMTF QRSLIDYEKL SHLNSSPTII WRRTGEIVSI SDEILSLLGY SLNSILSKRT
     FIMELMYDDE SIINYFKLFK SVAVGNLHSS IITRCKLMKN PDRDRSTRAS TTGTEQQLTE
     ADYIEFCAVW TVKRDLFDLP MLIMGQFLPV LPAGDGVRRY
//