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Protein

Eukaryotic translation initiation factor 3 subunit G

Gene

TIF35

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. This subunit can bind 18S rRNA.UniRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit GUniRule annotation
Short name:
eIF3gUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 RNA-binding subunitUniRule annotation
Short name:
eIF-3 RNA-binding subunitUniRule annotation
Translation initiation factor eIF3 p33 subunit homologUniRule annotation
Short name:
eIF3 p33 homologUniRule annotation
Gene namesi
Name:TIF35UniRule annotation
ORF Names:PGUG_04980
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Eukaryotic translation initiation factor 3 subunit GPRO_0000366893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461PhosphoserineUniRule annotation
Modified residuei164 – 1641PhosphoserineUniRule annotation
Modified residuei171 – 1711PhosphoserineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi4929.A5DNX9.

Structurei

3D structure databases

ProteinModelPortaliA5DNX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 27080RRMUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit G family.UniRule annotation
Contains 1 RRM (RNA recognition motif) domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0724.
InParanoidiA5DNX9.
KOiK03248.
OrthoDBiEOG7J44J3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_03006. eIF3g.
InterProiIPR017334. eIF3_g.
IPR024675. eIF3g_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR10352. PTHR10352. 1 hit.
PfamiPF12353. eIF3g. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DNX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSVIKSWA DAEDEIPAAE VINNPDGTKT VINYRMNANG QKIRHIQKIR
60 70 80 90 100
EVKVKEKVHP LIAMRKNWSK YGKEKDMPAG PDARTTQLGE VVELKLGTSW
110 120 130 140 150
KEIEKEEEEQ KAEQTQQIVS NQRIKCRTCG GNHFTSKCPF KDTLISDSAN
160 170 180 190 200
TSAAATPEPD TDASGKYVPP SLRKGAGAVR DMSGRDRDDS TTLKISQLNT
210 220 230 240 250
FVDEDMLRNE LLKRFHPLQR VTIVRNRETG ESRGFAYVSF VTERQAEEAL
260 270
NTLNGKGYHS LILHLEWPKK RKAN
Length:274
Mass (Da):30,908
Last modified:June 12, 2007 - v1
Checksum:iD530A9B3AAF553DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408160 Genomic DNA. Translation: EDK40882.1.
RefSeqiXP_001483025.1. XM_001482975.1.

Genome annotation databases

GeneIDi5124807.
KEGGipgu:PGUG_04980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408160 Genomic DNA. Translation: EDK40882.1.
RefSeqiXP_001483025.1. XM_001482975.1.

3D structure databases

ProteinModelPortaliA5DNX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4929.A5DNX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5124807.
KEGGipgu:PGUG_04980.

Phylogenomic databases

eggNOGiCOG0724.
InParanoidiA5DNX9.
KOiK03248.
OrthoDBiEOG7J44J3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_03006. eIF3g.
InterProiIPR017334. eIF3_g.
IPR024675. eIF3g_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR10352. PTHR10352. 1 hit.
PfamiPF12353. eIF3g. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiEIF3G_PICGU
AccessioniPrimary (citable) accession number: A5DNX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 12, 2007
Last modified: January 7, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.