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A5DNX9

- EIF3G_PICGU

UniProt

A5DNX9 - EIF3G_PICGU

Protein

Eukaryotic translation initiation factor 3 subunit G

Gene

TIF35

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. This subunit can bind 18S rRNA.UniRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    2. regulation of translational initiation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit GUniRule annotation
    Short name:
    eIF3gUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 RNA-binding subunitUniRule annotation
    Short name:
    eIF-3 RNA-binding subunitUniRule annotation
    Translation initiation factor eIF3 p33 subunit homologUniRule annotation
    Short name:
    eIF3 p33 homologUniRule annotation
    Gene namesi
    Name:TIF35UniRule annotation
    ORF Names:PGUG_04980
    OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
    Taxonomic identifieri294746 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
    ProteomesiUP000001997: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Eukaryotic translation initiation factor 3 subunit GPRO_0000366893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei146 – 1461PhosphoserineUniRule annotation
    Modified residuei164 – 1641PhosphoserineUniRule annotation
    Modified residuei171 – 1711PhosphoserineUniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi4929.A5DNX9.

    Structurei

    3D structure databases

    ProteinModelPortaliA5DNX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 27080RRMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit G family.UniRule annotation
    Contains 1 RRM (RNA recognition motif) domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0724.
    KOiK03248.
    OrthoDBiEOG7J44J3.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    HAMAPiMF_03006. eIF3g.
    InterProiIPR017334. eIF3_g.
    IPR024675. eIF3g_N.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PANTHERiPTHR10352. PTHR10352. 1 hit.
    PfamiPF12353. eIF3g. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5DNX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSVIKSWA DAEDEIPAAE VINNPDGTKT VINYRMNANG QKIRHIQKIR    50
    EVKVKEKVHP LIAMRKNWSK YGKEKDMPAG PDARTTQLGE VVELKLGTSW 100
    KEIEKEEEEQ KAEQTQQIVS NQRIKCRTCG GNHFTSKCPF KDTLISDSAN 150
    TSAAATPEPD TDASGKYVPP SLRKGAGAVR DMSGRDRDDS TTLKISQLNT 200
    FVDEDMLRNE LLKRFHPLQR VTIVRNRETG ESRGFAYVSF VTERQAEEAL 250
    NTLNGKGYHS LILHLEWPKK RKAN 274
    Length:274
    Mass (Da):30,908
    Last modified:June 12, 2007 - v1
    Checksum:iD530A9B3AAF553DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408160 Genomic DNA. Translation: EDK40882.1.
    RefSeqiXP_001483025.1. XM_001482975.1.

    Genome annotation databases

    GeneIDi5124807.
    KEGGipgu:PGUG_04980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408160 Genomic DNA. Translation: EDK40882.1 .
    RefSeqi XP_001483025.1. XM_001482975.1.

    3D structure databases

    ProteinModelPortali A5DNX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4929.A5DNX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5124807.
    KEGGi pgu:PGUG_04980.

    Phylogenomic databases

    eggNOGi COG0724.
    KOi K03248.
    OrthoDBi EOG7J44J3.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    HAMAPi MF_03006. eIF3g.
    InterProi IPR017334. eIF3_g.
    IPR024675. eIF3g_N.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    PANTHERi PTHR10352. PTHR10352. 1 hit.
    Pfami PF12353. eIF3g. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

    Entry informationi

    Entry nameiEIF3G_PICGU
    AccessioniPrimary (citable) accession number: A5DNX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3