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Protein

Eukaryotic translation initiation factor 3 subunit G

Gene

TIF35

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit GUniRule annotation
Short name:
eIF3gUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 RNA-binding subunitUniRule annotation
Short name:
eIF-3 RNA-binding subunitUniRule annotation
Translation initiation factor eIF3 p33 subunit homologUniRule annotation
Short name:
eIF3 p33 homologUniRule annotation
Gene namesi
Name:TIF35UniRule annotation
ORF Names:PGUG_04980
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003668931 – 274Eukaryotic translation initiation factor 3 subunit GAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineUniRule annotation1
Modified residuei164PhosphoserineUniRule annotation1
Modified residuei171PhosphoserineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA5DNX9

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi4929.A5DNX9

Structurei

3D structure databases

ProteinModelPortaliA5DNX9
SMRiA5DNX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 270RRMUniRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the eIF-3 subunit G family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0122 Eukaryota
ENOG410Y3CW LUCA
InParanoidiA5DNX9
KOiK03248
OMAiKMDGFGF
OrthoDBiEOG092C4BPC

Family and domain databases

CDDicd12933 eIF3G, 1 hit
cd12408 RRM_eIF3G_like, 1 hit
HAMAPiMF_03006 eIF3g, 1 hit
InterProiView protein in InterPro
IPR017334 eIF3_g
IPR024675 eIF3g_N
IPR034240 eIF3G_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10352:SF0 PTHR10352:SF0, 1 hit
PfamiView protein in Pfam
PF12353 eIF3g, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

A5DNX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSVIKSWA DAEDEIPAAE VINNPDGTKT VINYRMNANG QKIRHIQKIR
60 70 80 90 100
EVKVKEKVHP LIAMRKNWSK YGKEKDMPAG PDARTTQLGE VVELKLGTSW
110 120 130 140 150
KEIEKEEEEQ KAEQTQQIVS NQRIKCRTCG GNHFTSKCPF KDTLISDSAN
160 170 180 190 200
TSAAATPEPD TDASGKYVPP SLRKGAGAVR DMSGRDRDDS TTLKISQLNT
210 220 230 240 250
FVDEDMLRNE LLKRFHPLQR VTIVRNRETG ESRGFAYVSF VTERQAEEAL
260 270
NTLNGKGYHS LILHLEWPKK RKAN
Length:274
Mass (Da):30,908
Last modified:June 12, 2007 - v1
Checksum:iD530A9B3AAF553DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408160 Genomic DNA Translation: EDK40882.1
RefSeqiXP_001483025.1, XM_001482975.1

Genome annotation databases

EnsemblFungiiEDK40882; EDK40882; PGUG_04980
GeneIDi5124807
KEGGipgu:PGUG_04980

Similar proteinsi

Entry informationi

Entry nameiEIF3G_PICGU
AccessioniPrimary (citable) accession number: A5DNX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families
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