A5DNX8 (BNA7_PICGU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable kynurenine formamidase
EC=3.5.1.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 7
Probable N-formylkynurenine formamidase

Gene names

Name:	BNA7
ORF Names:	PGUG_04979

Organism

Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) [Complete proteome]

Taxonomic identifier

294746 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Meyerozyma

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H) By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the BNA7 family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Probable kynurenine formamidase		PRO_0000361883
Sites
	Active site	34	1	Potential
	Active site	103	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A5DNX8 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: 949D4D76B64A8318	FASTA	259	29,091
	10 20 30 40 50 60 MSSSKLLKYG SDDLQTIRVY RHDSGNHLSI IFIHGGAWRD PRNTFNDFEE LVGKLPSTIN 70 80 90 100 110 120 TFGINYRLSP AVKHPAHLED VVSAIEYLAK NYKVENVGLV GHSVGATLAL QILNYKTILP 130 140 150 160 170 180 GLERPLGIKM KFLVFLDGIY DVPKLVEEYP TYSSFVNEAF KTKQDYMRAT PVSSEMPQFD 190 200 210 220 230 240 ISVEKCVILL VQSTEDELLS VQQTELMADF LQAKSIPFEK HLGAFGAHEQ VYRHHKVAKL 250 ITDAIGANLD GLVRARPQN

References

[1]

"Evolution of pathogenicity and sexual reproduction in eight Candida genomes." Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S., Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J. , Harris D., Hoyer L.L., Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D., Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T., Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C., Birren B.W., Kellis M., Cuomo C.A. Nature 459:657-662(2009) [PubMed: 19465905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408160 Genomic DNA. Translation: EDK40881.2.
RefSeq	XP_001483024.1. XM_001482974.1.
3D structure databases
ProteinModelPortal	A5DNX8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5125016.
KEGG	pgu:PGUG_04979.
Phylogenomic databases
OrthoDB	EOG4GMZ6M.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
KO	K14263.
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BNA7_PICGU

Accession

Primary (citable) accession number: A5DNX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 22, 2008
Last modified:	December 14, 2011
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program