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A5DNQ2

- A5DNQ2_PICGU

UniProt

A5DNQ2 - A5DNQ2_PICGU

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
PGUG_04903
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Enzyme regulationi

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3 By similarity.UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferase
    Gene namesi
    ORF Names:PGUG_04903Imported
    OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
    Taxonomic identifieri294746 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
    ProteomesiUP000001997: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi4929.A5DNQ2.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5DNQ2-1 [UniParc]FASTAAdd to Basket

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    MAQIQGVECG VFSNPPNGVG INTYVDMHHT IHKETPEPLT PSDTNSVMSI    50
    KSIVTPSQDL PEEKQPNGGI SIENKEDLVS ILKDLVQVDL SMTSLRTKID 100
    VIDGEKIQNI LNTLEEYDPE ATTVEERQSI EKLATSNHTL KEIRQEHPFR 150
    DDVAVDRLST EFNPFLRRIK FKNNLDRLLY ISQWYTSSEF NAGKKPDGEI 200
    EDEAPTDGRR LRPRRKTKQV SPEPEKIEEE KPRTKRRRTK ATVKDETPES 250
    KDSGDKYNPF DPENILEDTF LPLHGRHAFA DSIYIDAPSL PPLVTNVEPK 300
    LGVSVDTSAS NLITQHTKHY KNLPSSFPTL FITNSDGQEV ANVNNRIRIR 350
    FLLYPMHCEE YVLAQPKSNQ LDPVDEIIKF FQVNYGLYFS GSTKIRNIIV 400
    TNYCQKLREA VDDDDLASFV TIIDKWNQLV LHLSPNPSFW SDINPEIRMY 450
    TKKIEEKFSE SDLKINIFHT EIAKLVAKHQ GDKQDKNQTN ETNDNDHTVI 500
    PGSNGSVLAG DSISRYKRDF FCQLASNQKI SRYALHQILS RVYARVVSIS 550
    SNKLRYYKAF TAEVYGELLP CFTSEVLTKV GMKPHHKFYD LGSGVGNTTL 600
    QAALEFGAAL SGGCELMAHA SKLTLEQSNM VQRNLSVFGL KQLNLEWALS 650
    QSFADNEQVR RTVIDCDILI VNNYLFDAEL NYKVGKLLYG LRPGSKIVSL 700
    RNFISPRYKA SFDDTVFDYL QVEKHEMEHN MSVSWTANKV PYYISVVQKE 750
    VCKQYL 756
    Length:756
    Mass (Da):86,139
    Last modified:July 22, 2008 - v2
    Checksum:i66B4EF1B62BEF45F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408160 Genomic DNA. Translation: EDK40806.2.
    RefSeqiXP_001482949.1. XM_001482899.1.

    Genome annotation databases

    GeneIDi5124947.
    KEGGipgu:PGUG_04903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408160 Genomic DNA. Translation: EDK40806.2 .
    RefSeqi XP_001482949.1. XM_001482899.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 4929.A5DNQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5124947.
    KEGGi pgu:PGUG_04903.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

    Entry informationi

    Entry nameiA5DNQ2_PICGU
    AccessioniPrimary (citable) accession number: A5DNQ2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: July 22, 2008
    Last modified: June 11, 2014
    This is version 36 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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