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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44DioxygenUniRule annotation1
Metal bindingi48Iron; catalyticUniRule annotation1
Metal bindingi54Iron; catalyticUniRule annotation1
Binding sitei54SubstrateUniRule annotation1
Metal bindingi92Iron; catalyticUniRule annotation1
Binding sitei96SubstrateUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Metal bindingi121Divalent metal cationUniRule annotation1
Metal bindingi124Divalent metal cationUniRule annotation1
Metal bindingi158Divalent metal cationUniRule annotation1
Metal bindingi160Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
ORF Names:PGUG_04264
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003619921 – 1693-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST169

Proteomic databases

PRIDEiA5DLW3

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DLW3

Structurei

3D structure databases

SMRiA5DLW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3995 Eukaryota
ENOG4111GH8 LUCA
InParanoidiA5DLW3
KOiK00452
OMAiNARKDYH
OrthoDBiEOG092C5CUF

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00825 3_HAO, 1 hit
InterProiView protein in InterPro
IPR010329 3hydroanth_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR15497 PTHR15497, 1 hit
PfamiView protein in Pfam
PF06052 3-HAO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR03037 anthran_nbaC, 1 hit

Sequencei

Sequence statusi: Complete.

A5DLW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAEPINLQS WISENKDLLQ PPVNNYCLHR GGATVMIVGG PNERTDYHVN
60 70 80 90 100
QTPEYFHQIK GDMTLKVVDD GKFRDITIRE GDSFLLPGNV PHNPVRYADT
110 120 130 140 150
IGLVVEQDRP KGVNDKIRWY CSNCREIVHQ VEFYCYDLGT QVKDAILAFD
160
GDDEARTCKC GTYNYSRPN
Length:169
Mass (Da):19,284
Last modified:July 22, 2008 - v2
Checksum:i8E7F890431BA2F0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408159 Genomic DNA Translation: EDK40166.2
RefSeqiXP_001483535.1, XM_001483485.1

Genome annotation databases

EnsemblFungiiEDK40166; EDK40166; PGUG_04264
GeneIDi5125307
KEGGipgu:PGUG_04264

Similar proteinsi

Entry informationi

Entry namei3HAO_PICGU
AccessioniPrimary (citable) accession number: A5DLW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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