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Protein

Histone deacetylase

Gene

PGUG_03521

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei122SubstrateUniRule annotation1
Active sitei164Proton acceptorUniRule annotation1
Binding sitei172Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi199Divalent metal cationUniRule annotation1
Metal bindingi201Divalent metal cationUniRule annotation1
Metal bindingi288Divalent metal cationUniRule annotation1
Binding sitei327SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:PGUG_03521Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DJS0.

Structurei

3D structure databases

ProteinModelPortaliA5DJS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 343Hist_deacetylInterPro annotationAdd BLAST294

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiA5DJS0.
KOiK11483.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

A5DJS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPVSETDT FSPDKKTAEN TPFYDSICKQ SNVSYHFNPE VSQYHFGPYH
60 70 80 90 100
PMKPFRLMLT DHLVISYKLY EKMDLYTPRR ATKEELLEFH SDDYIDFLAK
110 120 130 140 150
VTPETVTKLP ESTLAHFNIG DDCPVFDGMY DYSTIYAGAT LDASRKLISG
160 170 180 190 200
MSDIAINWSG GLHHAKKYEP SGFCYVNDIV LSIINLLRVH PRVMYIDIDL
210 220 230 240 250
HHGDGVQEAF YATDRVMTVS FHKYNGEFFP GTGSIDERGM DKGKNFAINV
260 270 280 290 300
PLKDGIDDES YVRLFKSIME PLITKFQPTC IVQQCGADSL GYDRLGCFNL
310 320 330 340 350
NIKAHGECVK FIKSFEIPML VLGGGGYTPR NVSRLWCYET SVLTDVTLNH
360 370 380 390 400
KIPNYLPSYD WFGPDFSLHP QLDGRIDNKN SKKYLESVKQ DILEQLRYLA
410 420 430 440 450
YAPSVQMQEI PPDITGLTED EDQIIKELNE EQDGTRETQN TKDEARVGEL

RE
Length:452
Mass (Da):51,577
Last modified:July 22, 2008 - v2
Checksum:i10390C4AB77FC29A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408158 Genomic DNA. Translation: EDK39423.2.
RefSeqiXP_001484140.1. XM_001484090.1.

Genome annotation databases

EnsemblFungiiEDK39423; EDK39423; PGUG_03521.
GeneIDi5126380.
KEGGipgu:PGUG_03521.

Similar proteinsi

Entry informationi

Entry nameiA5DJS0_PICGU
AccessioniPrimary (citable) accession number: A5DJS0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: November 22, 2017
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported