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A5DI46

- PMIP_PICGU

UniProt

A5DI46 - PMIP_PICGU

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
Active sitei568 – 5681PROSITE-ProRule annotation
Metal bindingi571 – 5711Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:PGUG_02947
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 786757Mitochondrial intermediate peptidasePRO_0000338592Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DI46.

Structurei

3D structure databases

ProteinModelPortaliA5DI46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
InParanoidiA5DI46.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5DI46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSILLRSYR HHAKVWTRPS SKSSFIRSLA SRSNPTSSFE HVRRVFDDDK
60 70 80 90 100
YYQDFNNGTL SRKIFSGPRT GLFKNEKLTT PQGLIDFSGQ CLTEAQTLVD
110 120 130 140 150
TMIREAETSD QGKIHYIRRL DQLSDILCRV IDVAEFIRVA HPNSKWTHAA
160 170 180 190 200
QQTHELMFEY MNQLNTNVQL HTILGNILAD KSITSKLSSE EIMVGEYLKQ
210 220 230 240 250
DFERSGIYME PHTRENFVAL TQEISVLGSH FNNGIHELKD YWCEISQQEY
260 270 280 290 300
EAIDNADLKR EIRRFQQKSP RSSRNSVYIP LAGSLPYSIL QRCSMESVRR
310 320 330 340 350
KVWIALHNAS EEQISTLNLF LKYRATLSKM LGYESFAHYQ LEHKMAKNPE
360 370 380 390 400
NVLTFLENLQ RKMVDGENSG LISELESLYA MSNHWKPGAS KSDIIHAIQP
410 420 430 440 450
WDRDYLLHKL QEEKKETQLD DNISEYLSVG TIMSGLSQLF HSIYSIELLP
460 470 480 490 500
EPSASGETWA SQVRKIKVFD NETQSTLGFL YLDFWSPNVL PSHFTIVCSR
510 520 530 540 550
QLNKDLGEKV EVMKPLVQLD ETESHQLPVI SLVCNFHQGN SFIGRFAGLE
560 570 580 590 600
TSKPTLLTLD QVDTIFHEMG HAMHSMIGRT KLQNLSGTRC STDFVELPSV
610 620 630 640 650
LMESFSKDPR VLGRIARHYS TNELLPHDIL AKHQHYRNVL ENSETYMQSK
660 670 680 690 700
MAMLDQVLHG KSIVKQLEMA RDDIDSTTMY HSLEKELKVF SDQWSTWHGK
710 720 730 740 750
FPHLFSYGAV YFSYLFDRAI AEKIWKSLFQ NDPWSREAGT TYKEAILKWG
760 770 780
GTRDPWHCLA DALSNQELSK GDEKAMRIIG GETKDL
Length:786
Mass (Da):90,517
Last modified:February 10, 2009 - v2
Checksum:i784FAB0D1430E2E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38849.2.
RefSeqiXP_001485218.1. XM_001485168.1.

Genome annotation databases

GeneIDi5127052.
KEGGipgu:PGUG_02947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38849.2 .
RefSeqi XP_001485218.1. XM_001485168.1.

3D structure databases

ProteinModelPortali A5DI46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4929.A5DI46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5127052.
KEGGi pgu:PGUG_02947.

Phylogenomic databases

eggNOGi COG0339.
InParanoidi A5DI46.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiPMIP_PICGU
AccessioniPrimary (citable) accession number: A5DI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3