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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi567Zinc; catalyticPROSITE-ProRule annotation1
Active sitei568PROSITE-ProRule annotation1
Metal bindingi571Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi574Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:PGUG_02947
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000033859230 – 786Mitochondrial intermediate peptidaseAdd BLAST757

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DI46

Structurei

3D structure databases

ProteinModelPortaliA5DI46
SMRiA5DI46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
InParanoidiA5DI46
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5DI46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSILLRSYR HHAKVWTRPS SKSSFIRSLA SRSNPTSSFE HVRRVFDDDK
60 70 80 90 100
YYQDFNNGTL SRKIFSGPRT GLFKNEKLTT PQGLIDFSGQ CLTEAQTLVD
110 120 130 140 150
TMIREAETSD QGKIHYIRRL DQLSDILCRV IDVAEFIRVA HPNSKWTHAA
160 170 180 190 200
QQTHELMFEY MNQLNTNVQL HTILGNILAD KSITSKLSSE EIMVGEYLKQ
210 220 230 240 250
DFERSGIYME PHTRENFVAL TQEISVLGSH FNNGIHELKD YWCEISQQEY
260 270 280 290 300
EAIDNADLKR EIRRFQQKSP RSSRNSVYIP LAGSLPYSIL QRCSMESVRR
310 320 330 340 350
KVWIALHNAS EEQISTLNLF LKYRATLSKM LGYESFAHYQ LEHKMAKNPE
360 370 380 390 400
NVLTFLENLQ RKMVDGENSG LISELESLYA MSNHWKPGAS KSDIIHAIQP
410 420 430 440 450
WDRDYLLHKL QEEKKETQLD DNISEYLSVG TIMSGLSQLF HSIYSIELLP
460 470 480 490 500
EPSASGETWA SQVRKIKVFD NETQSTLGFL YLDFWSPNVL PSHFTIVCSR
510 520 530 540 550
QLNKDLGEKV EVMKPLVQLD ETESHQLPVI SLVCNFHQGN SFIGRFAGLE
560 570 580 590 600
TSKPTLLTLD QVDTIFHEMG HAMHSMIGRT KLQNLSGTRC STDFVELPSV
610 620 630 640 650
LMESFSKDPR VLGRIARHYS TNELLPHDIL AKHQHYRNVL ENSETYMQSK
660 670 680 690 700
MAMLDQVLHG KSIVKQLEMA RDDIDSTTMY HSLEKELKVF SDQWSTWHGK
710 720 730 740 750
FPHLFSYGAV YFSYLFDRAI AEKIWKSLFQ NDPWSREAGT TYKEAILKWG
760 770 780
GTRDPWHCLA DALSNQELSK GDEKAMRIIG GETKDL
Length:786
Mass (Da):90,517
Last modified:February 10, 2009 - v2
Checksum:i784FAB0D1430E2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408157 Genomic DNA Translation: EDK38849.2
RefSeqiXP_001485218.1, XM_001485168.1

Genome annotation databases

EnsemblFungiiEDK38849; EDK38849; PGUG_02947
GeneIDi5127052
KEGGipgu:PGUG_02947

Similar proteinsi

Entry informationi

Entry nameiPMIP_PICGU
AccessioniPrimary (citable) accession number: A5DI46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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