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A5DI46

- PMIP_PICGU

UniProt

A5DI46 - PMIP_PICGU

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Protein

Mitochondrial intermediate peptidase

Gene
OCT1, PGUG_02947
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi567 – 5671Zinc; catalytic By similarity
Active sitei568 – 5681 By similarity
Metal bindingi571 – 5711Zinc; catalytic By similarity
Metal bindingi574 – 5741Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:PGUG_02947
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion Reviewed predictionAdd
BLAST
Chaini30 – 786757Mitochondrial intermediate peptidasePRO_0000338592Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DI46.

Structurei

3D structure databases

ProteinModelPortaliA5DI46.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5DI46-1 [UniParc]FASTAAdd to Basket

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MSSILLRSYR HHAKVWTRPS SKSSFIRSLA SRSNPTSSFE HVRRVFDDDK    50
YYQDFNNGTL SRKIFSGPRT GLFKNEKLTT PQGLIDFSGQ CLTEAQTLVD 100
TMIREAETSD QGKIHYIRRL DQLSDILCRV IDVAEFIRVA HPNSKWTHAA 150
QQTHELMFEY MNQLNTNVQL HTILGNILAD KSITSKLSSE EIMVGEYLKQ 200
DFERSGIYME PHTRENFVAL TQEISVLGSH FNNGIHELKD YWCEISQQEY 250
EAIDNADLKR EIRRFQQKSP RSSRNSVYIP LAGSLPYSIL QRCSMESVRR 300
KVWIALHNAS EEQISTLNLF LKYRATLSKM LGYESFAHYQ LEHKMAKNPE 350
NVLTFLENLQ RKMVDGENSG LISELESLYA MSNHWKPGAS KSDIIHAIQP 400
WDRDYLLHKL QEEKKETQLD DNISEYLSVG TIMSGLSQLF HSIYSIELLP 450
EPSASGETWA SQVRKIKVFD NETQSTLGFL YLDFWSPNVL PSHFTIVCSR 500
QLNKDLGEKV EVMKPLVQLD ETESHQLPVI SLVCNFHQGN SFIGRFAGLE 550
TSKPTLLTLD QVDTIFHEMG HAMHSMIGRT KLQNLSGTRC STDFVELPSV 600
LMESFSKDPR VLGRIARHYS TNELLPHDIL AKHQHYRNVL ENSETYMQSK 650
MAMLDQVLHG KSIVKQLEMA RDDIDSTTMY HSLEKELKVF SDQWSTWHGK 700
FPHLFSYGAV YFSYLFDRAI AEKIWKSLFQ NDPWSREAGT TYKEAILKWG 750
GTRDPWHCLA DALSNQELSK GDEKAMRIIG GETKDL 786
Length:786
Mass (Da):90,517
Last modified:February 10, 2009 - v2
Checksum:i784FAB0D1430E2E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38849.2.
RefSeqiXP_001485218.1. XM_001485168.1.

Genome annotation databases

GeneIDi5127052.
KEGGipgu:PGUG_02947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38849.2 .
RefSeqi XP_001485218.1. XM_001485168.1.

3D structure databases

ProteinModelPortali A5DI46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4929.A5DI46.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5127052.
KEGGi pgu:PGUG_02947.

Phylogenomic databases

eggNOGi COG0339.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiPMIP_PICGU
AccessioniPrimary (citable) accession number: A5DI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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