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A5DI46

- PMIP_PICGU

UniProt

A5DI46 - PMIP_PICGU

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
    Active sitei568 – 5681PROSITE-ProRule annotation
    Metal bindingi571 – 5711Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:PGUG_02947
    OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
    Taxonomic identifieri294746 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
    ProteomesiUP000001997: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 786757Mitochondrial intermediate peptidasePRO_0000338592Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4929.A5DI46.

    Structurei

    3D structure databases

    ProteinModelPortaliA5DI46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5DI46-1 [UniParc]FASTAAdd to Basket

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    MSSILLRSYR HHAKVWTRPS SKSSFIRSLA SRSNPTSSFE HVRRVFDDDK    50
    YYQDFNNGTL SRKIFSGPRT GLFKNEKLTT PQGLIDFSGQ CLTEAQTLVD 100
    TMIREAETSD QGKIHYIRRL DQLSDILCRV IDVAEFIRVA HPNSKWTHAA 150
    QQTHELMFEY MNQLNTNVQL HTILGNILAD KSITSKLSSE EIMVGEYLKQ 200
    DFERSGIYME PHTRENFVAL TQEISVLGSH FNNGIHELKD YWCEISQQEY 250
    EAIDNADLKR EIRRFQQKSP RSSRNSVYIP LAGSLPYSIL QRCSMESVRR 300
    KVWIALHNAS EEQISTLNLF LKYRATLSKM LGYESFAHYQ LEHKMAKNPE 350
    NVLTFLENLQ RKMVDGENSG LISELESLYA MSNHWKPGAS KSDIIHAIQP 400
    WDRDYLLHKL QEEKKETQLD DNISEYLSVG TIMSGLSQLF HSIYSIELLP 450
    EPSASGETWA SQVRKIKVFD NETQSTLGFL YLDFWSPNVL PSHFTIVCSR 500
    QLNKDLGEKV EVMKPLVQLD ETESHQLPVI SLVCNFHQGN SFIGRFAGLE 550
    TSKPTLLTLD QVDTIFHEMG HAMHSMIGRT KLQNLSGTRC STDFVELPSV 600
    LMESFSKDPR VLGRIARHYS TNELLPHDIL AKHQHYRNVL ENSETYMQSK 650
    MAMLDQVLHG KSIVKQLEMA RDDIDSTTMY HSLEKELKVF SDQWSTWHGK 700
    FPHLFSYGAV YFSYLFDRAI AEKIWKSLFQ NDPWSREAGT TYKEAILKWG 750
    GTRDPWHCLA DALSNQELSK GDEKAMRIIG GETKDL 786
    Length:786
    Mass (Da):90,517
    Last modified:February 10, 2009 - v2
    Checksum:i784FAB0D1430E2E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408157 Genomic DNA. Translation: EDK38849.2.
    RefSeqiXP_001485218.1. XM_001485168.1.

    Genome annotation databases

    GeneIDi5127052.
    KEGGipgu:PGUG_02947.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408157 Genomic DNA. Translation: EDK38849.2 .
    RefSeqi XP_001485218.1. XM_001485168.1.

    3D structure databases

    ProteinModelPortali A5DI46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4929.A5DI46.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5127052.
    KEGGi pgu:PGUG_02947.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

    Entry informationi

    Entry nameiPMIP_PICGU
    AccessioniPrimary (citable) accession number: A5DI46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3