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A5DHA3

- NTE1_PICGU

UniProt

A5DHA3 - NTE1_PICGU

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1164 – 11641By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi590 – 720131cNMP 1Add
BLAST
Nucleotide bindingi707 – 856150cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:PGUG_02654
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14381438Lysophospholipase NTE1PRO_0000295328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DHA3.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicBy similarityAdd
BLAST
Topological domaini47 – 6418LumenalBy similarityAdd
BLAST
Topological domaini86 – 14381353CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1131 – 1295165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1162 – 11665GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiA5DHA3.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DHA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDTSSADF HSTETLVSTP KYSYGVLINV ILLVSWTCFR VVNWFLVTLP
60 70 80 90 100
SILLGMLSKT FQITLSLSSI LMFVVAVTAI CFLVVRYKYL TRYSRNSAAK
110 120 130 140 150
EPAKKSFDID DLSKKKKSSS KTSSNYLDQF LSAIQVFGYL EGPVFHELTR
160 170 180 190 200
NMTTQKVLPN EVLYLDESLG FSIVVEGTMQ VYTKVTNLSN SSLNAEDDGL
210 220 230 240 250
DLRYENDDVL CIGNDKYQLL NEVKSGAPLS SLMSTLDLFT SNEVPLSPTK
260 270 280 290 300
FGSYSLTAVT PLELSPNNTG GNSPPPSLAP EIVARPKGTT STTLAIIPYT
310 320 330 340 350
AFQRLHKKYP KATSHIVTMV LTRLYKVSMN TIYNYLGLSK DILDCERNLN
360 370 380 390 400
AETNERLPSY LSKGIIEKFH KTEESASVEG SPTLPRRSTV NLRALTRQAS
410 420 430 440 450
SSRYVVLASR SKSTHPGDLL SSVPLSRRSD YYETQTIPNE SEDSPTIQRS
460 470 480 490 500
SLRRRASHST SLRKSNSVLE DIRVRGFSNE REETEETSLR TAIVEQIFTH
510 520 530 540 550
LGISEDDPTV MNINPTSASS SASSSIVGIS KLNYGSLDSI NSPRVDPMTS
560 570 580 590 600
IRSSLASNGN KVYQTINQHT KEADVLQEKP KKVVLPGSRG DDSDFVAVKD
610 620 630 640 650
EFARAIQMKY IQPGKTIIEQ DSFHTGIFYV IDGSLDVIQE SNGKSKKIYT
660 670 680 690 700
VKAGGITGYL NCLIGMKSLV SVKASEDSSA IVAHIPSHMY SKLIDKFYFL
710 720 730 740 750
QLPIARRLKR LLSKQFLTID YALEWCHISA GDILSKEGEP ANGFHIVLSG
760 770 780 790 800
RFRVVKFKTP FKPVASKAGH DTYDYNDNLI DESNKKYTSN DVEILGEYGH
810 820 830 840 850
GESIGEVEVL TASLRKNTLI AVRDSETARI PRALFELLSL QNPSIMVKVS
860 870 880 890 900
RIVANRLSKK DSEEILDKPL AMTSSDSPYI SSNFKTITIL PTVSQLPVRE
910 920 930 940 950
FADKLVQALK AIGRNVIALD QASTLTHLGK HAFDERLAEL KLSGYFAYLE
960 970 980 990 1000
EKYETIVYVC DTPVKSNWTS TCISQGDCIL LLADADDEDT AESIGSYERL
1010 1020 1030 1040 1050
LIKLKTTART DLCLIHPEKY VTPGSTSIWL KNRVWVQGHH HIQMEISPTQ
1060 1070 1080 1090 1100
TTSVMKPKIP IISELAKKIK DRANPNIKLK LEEVKGKALA SFVKLNNKIN
1110 1120 1130 1140 1150
AHGRMSFNGV SVHKNDFLRL ARILSNEAVG LVLGGGGSRG ISHVGVVIAL
1160 1170 1180 1190 1200
EKHGIPIDLV GGTSIGSFVG GLYAMDYNTV SIYGRAKKFA KRVSSFWRIL
1210 1220 1230 1240 1250
TDLTYPVTSY MTGYEFNRGI WKIFGFTEIE DFWLRYFCNS TNITNSTMDI
1260 1270 1280 1290 1300
HETGYSWRFI RASMSLAGLL PPITYNGSML LDGGYLDNLP VSEMKKKGAK
1310 1320 1330 1340 1350
YIIAVDVGSV DDRTPMNYGD TLSGFWVLLN RWNPFSKHPD VPNMMDIQLR
1360 1370 1380 1390 1400
LAYVASVNAL EISKKTPGVM YLRPPIENYA TLDFAKYDEI YRVGYVYADE
1410 1420 1430
LFTSWKSSGK LPDIAGMGDK VRKDMSGEHV SLSRRNSI
Length:1,438
Mass (Da):160,000
Last modified:February 10, 2009 - v2
Checksum:i4961090B281985BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38556.2.
RefSeqiXP_001484925.1. XM_001484875.1.

Genome annotation databases

GeneIDi5127010.
KEGGipgu:PGUG_02654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38556.2 .
RefSeqi XP_001484925.1. XM_001484875.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4929.A5DHA3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5127010.
KEGGi pgu:PGUG_02654.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi A5DHA3.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiNTE1_PICGU
AccessioniPrimary (citable) accession number: A5DHA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3