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A5DHA3

- NTE1_PICGU

UniProt

A5DHA3 - NTE1_PICGU

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1164 – 11641By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi590 – 720131cNMP 1Add
    BLAST
    Nucleotide bindingi707 – 856150cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:PGUG_02654
    OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
    Taxonomic identifieri294746 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
    ProteomesiUP000001997: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14381438Lysophospholipase NTE1PRO_0000295328Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4929.A5DHA3.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525CytoplasmicBy similarityAdd
    BLAST
    Topological domaini47 – 6418LumenalBy similarityAdd
    BLAST
    Topological domaini86 – 14381353CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1131 – 1295165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1162 – 11665GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5DHA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDTSSADF HSTETLVSTP KYSYGVLINV ILLVSWTCFR VVNWFLVTLP     50
    SILLGMLSKT FQITLSLSSI LMFVVAVTAI CFLVVRYKYL TRYSRNSAAK 100
    EPAKKSFDID DLSKKKKSSS KTSSNYLDQF LSAIQVFGYL EGPVFHELTR 150
    NMTTQKVLPN EVLYLDESLG FSIVVEGTMQ VYTKVTNLSN SSLNAEDDGL 200
    DLRYENDDVL CIGNDKYQLL NEVKSGAPLS SLMSTLDLFT SNEVPLSPTK 250
    FGSYSLTAVT PLELSPNNTG GNSPPPSLAP EIVARPKGTT STTLAIIPYT 300
    AFQRLHKKYP KATSHIVTMV LTRLYKVSMN TIYNYLGLSK DILDCERNLN 350
    AETNERLPSY LSKGIIEKFH KTEESASVEG SPTLPRRSTV NLRALTRQAS 400
    SSRYVVLASR SKSTHPGDLL SSVPLSRRSD YYETQTIPNE SEDSPTIQRS 450
    SLRRRASHST SLRKSNSVLE DIRVRGFSNE REETEETSLR TAIVEQIFTH 500
    LGISEDDPTV MNINPTSASS SASSSIVGIS KLNYGSLDSI NSPRVDPMTS 550
    IRSSLASNGN KVYQTINQHT KEADVLQEKP KKVVLPGSRG DDSDFVAVKD 600
    EFARAIQMKY IQPGKTIIEQ DSFHTGIFYV IDGSLDVIQE SNGKSKKIYT 650
    VKAGGITGYL NCLIGMKSLV SVKASEDSSA IVAHIPSHMY SKLIDKFYFL 700
    QLPIARRLKR LLSKQFLTID YALEWCHISA GDILSKEGEP ANGFHIVLSG 750
    RFRVVKFKTP FKPVASKAGH DTYDYNDNLI DESNKKYTSN DVEILGEYGH 800
    GESIGEVEVL TASLRKNTLI AVRDSETARI PRALFELLSL QNPSIMVKVS 850
    RIVANRLSKK DSEEILDKPL AMTSSDSPYI SSNFKTITIL PTVSQLPVRE 900
    FADKLVQALK AIGRNVIALD QASTLTHLGK HAFDERLAEL KLSGYFAYLE 950
    EKYETIVYVC DTPVKSNWTS TCISQGDCIL LLADADDEDT AESIGSYERL 1000
    LIKLKTTART DLCLIHPEKY VTPGSTSIWL KNRVWVQGHH HIQMEISPTQ 1050
    TTSVMKPKIP IISELAKKIK DRANPNIKLK LEEVKGKALA SFVKLNNKIN 1100
    AHGRMSFNGV SVHKNDFLRL ARILSNEAVG LVLGGGGSRG ISHVGVVIAL 1150
    EKHGIPIDLV GGTSIGSFVG GLYAMDYNTV SIYGRAKKFA KRVSSFWRIL 1200
    TDLTYPVTSY MTGYEFNRGI WKIFGFTEIE DFWLRYFCNS TNITNSTMDI 1250
    HETGYSWRFI RASMSLAGLL PPITYNGSML LDGGYLDNLP VSEMKKKGAK 1300
    YIIAVDVGSV DDRTPMNYGD TLSGFWVLLN RWNPFSKHPD VPNMMDIQLR 1350
    LAYVASVNAL EISKKTPGVM YLRPPIENYA TLDFAKYDEI YRVGYVYADE 1400
    LFTSWKSSGK LPDIAGMGDK VRKDMSGEHV SLSRRNSI 1438
    Length:1,438
    Mass (Da):160,000
    Last modified:February 10, 2009 - v2
    Checksum:i4961090B281985BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408157 Genomic DNA. Translation: EDK38556.2.
    RefSeqiXP_001484925.1. XM_001484875.1.

    Genome annotation databases

    GeneIDi5127010.
    KEGGipgu:PGUG_02654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408157 Genomic DNA. Translation: EDK38556.2 .
    RefSeqi XP_001484925.1. XM_001484875.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4929.A5DHA3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5127010.
    KEGGi pgu:PGUG_02654.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

    Entry informationi

    Entry nameiNTE1_PICGU
    AccessioniPrimary (citable) accession number: A5DHA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3