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A5DHA3

- NTE1_PICGU

UniProt

A5DHA3 - NTE1_PICGU

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Protein
Lysophospholipase NTE1
Gene
NTE1, PGUG_02654
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1164 – 11641 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi590 – 720131cNMP 1
Add
BLAST
Nucleotide bindingi707 – 856150cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:PGUG_02654
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic By similarity
Add
BLAST
Transmembranei26 – 4621Helical; Reviewed prediction
Add
BLAST
Topological domaini47 – 6418Lumenal By similarity
Add
BLAST
Transmembranei65 – 8521Helical; Reviewed prediction
Add
BLAST
Topological domaini86 – 14381353Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14381438Lysophospholipase NTE1
PRO_0000295328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DHA3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1131 – 1295165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1162 – 11665GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DHA3-1 [UniParc]FASTAAdd to Basket

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MDSDTSSADF HSTETLVSTP KYSYGVLINV ILLVSWTCFR VVNWFLVTLP     50
SILLGMLSKT FQITLSLSSI LMFVVAVTAI CFLVVRYKYL TRYSRNSAAK 100
EPAKKSFDID DLSKKKKSSS KTSSNYLDQF LSAIQVFGYL EGPVFHELTR 150
NMTTQKVLPN EVLYLDESLG FSIVVEGTMQ VYTKVTNLSN SSLNAEDDGL 200
DLRYENDDVL CIGNDKYQLL NEVKSGAPLS SLMSTLDLFT SNEVPLSPTK 250
FGSYSLTAVT PLELSPNNTG GNSPPPSLAP EIVARPKGTT STTLAIIPYT 300
AFQRLHKKYP KATSHIVTMV LTRLYKVSMN TIYNYLGLSK DILDCERNLN 350
AETNERLPSY LSKGIIEKFH KTEESASVEG SPTLPRRSTV NLRALTRQAS 400
SSRYVVLASR SKSTHPGDLL SSVPLSRRSD YYETQTIPNE SEDSPTIQRS 450
SLRRRASHST SLRKSNSVLE DIRVRGFSNE REETEETSLR TAIVEQIFTH 500
LGISEDDPTV MNINPTSASS SASSSIVGIS KLNYGSLDSI NSPRVDPMTS 550
IRSSLASNGN KVYQTINQHT KEADVLQEKP KKVVLPGSRG DDSDFVAVKD 600
EFARAIQMKY IQPGKTIIEQ DSFHTGIFYV IDGSLDVIQE SNGKSKKIYT 650
VKAGGITGYL NCLIGMKSLV SVKASEDSSA IVAHIPSHMY SKLIDKFYFL 700
QLPIARRLKR LLSKQFLTID YALEWCHISA GDILSKEGEP ANGFHIVLSG 750
RFRVVKFKTP FKPVASKAGH DTYDYNDNLI DESNKKYTSN DVEILGEYGH 800
GESIGEVEVL TASLRKNTLI AVRDSETARI PRALFELLSL QNPSIMVKVS 850
RIVANRLSKK DSEEILDKPL AMTSSDSPYI SSNFKTITIL PTVSQLPVRE 900
FADKLVQALK AIGRNVIALD QASTLTHLGK HAFDERLAEL KLSGYFAYLE 950
EKYETIVYVC DTPVKSNWTS TCISQGDCIL LLADADDEDT AESIGSYERL 1000
LIKLKTTART DLCLIHPEKY VTPGSTSIWL KNRVWVQGHH HIQMEISPTQ 1050
TTSVMKPKIP IISELAKKIK DRANPNIKLK LEEVKGKALA SFVKLNNKIN 1100
AHGRMSFNGV SVHKNDFLRL ARILSNEAVG LVLGGGGSRG ISHVGVVIAL 1150
EKHGIPIDLV GGTSIGSFVG GLYAMDYNTV SIYGRAKKFA KRVSSFWRIL 1200
TDLTYPVTSY MTGYEFNRGI WKIFGFTEIE DFWLRYFCNS TNITNSTMDI 1250
HETGYSWRFI RASMSLAGLL PPITYNGSML LDGGYLDNLP VSEMKKKGAK 1300
YIIAVDVGSV DDRTPMNYGD TLSGFWVLLN RWNPFSKHPD VPNMMDIQLR 1350
LAYVASVNAL EISKKTPGVM YLRPPIENYA TLDFAKYDEI YRVGYVYADE 1400
LFTSWKSSGK LPDIAGMGDK VRKDMSGEHV SLSRRNSI 1438
Length:1,438
Mass (Da):160,000
Last modified:February 10, 2009 - v2
Checksum:i4961090B281985BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38556.2.
RefSeqiXP_001484925.1. XM_001484875.1.

Genome annotation databases

GeneIDi5127010.
KEGGipgu:PGUG_02654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408157 Genomic DNA. Translation: EDK38556.2 .
RefSeqi XP_001484925.1. XM_001484875.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4929.A5DHA3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5127010.
KEGGi pgu:PGUG_02654.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiNTE1_PICGU
AccessioniPrimary (citable) accession number: A5DHA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 10, 2009
Last modified: February 19, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi