ID   A5DGL6_PICGU            Unreviewed;       512 AA.
AC   A5DGL6;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Aldehyde dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF00171};
GN   ORFNames=PGUG_02417 {ECO:0000313|EMBL:EDK38319.1};
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK38319.1, ECO:0000313|Proteomes:UP000001997};
RN   [1] {ECO:0000313|EMBL:EDK38319.1, ECO:0000313|Proteomes:UP000001997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324 {ECO:0000313|Proteomes:UP000001997};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CH408157; EDK38319.1; -; Genomic_DNA.
DR   RefSeq; XP_001484688.1; XM_001484638.1.
DR   AlphaFoldDB; A5DGL6; -.
DR   STRING; 294746.A5DGL6; -.
DR   GeneID; 5126721; -.
DR   KEGG; pgu:PGUG_02417; -.
DR   VEuPathDB; FungiDB:PGUG_02417; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   InParanoid; A5DGL6; -.
DR   OMA; TWINTHM; -.
DR   OrthoDB; 216092at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001997}.
FT   DOMAIN          32..495
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        265
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   512 AA;  55506 MW;  26FD06D6CE453126 CRC64;
     MSVTIQSYGD CKITIKTGLF INNEFKPSVG GTVMTTPNPA TGEDLATISS ATAEDVDIAV
     SAARLAFETT WGKKSTPDQR SSLLNKWAEL IEADIDSLAE LESLDNGKPV WMARDVDIVD
     SIGCLRYYAG LADKIEGRTI EQQEGIKLAF TRAEPIGVCG QIIPWNYPIQ MFMWKVAPAL
     AAGNTIVIKP AEQTPLSALR LAELAVEAGF PPGVLNVVNG PGAVTGDAIS RHMDIDKVAF
     TGSTVTGRKI MEAAAKSNLK KVTLELGGKS PVVVFDSVDI DQTANWVCMA ILFNHGQDCC
     AGSRLFVQDT IKDEFLATLK KKVEQVEIGD PSVKTTFIGP LVSKQQQEKV KKYIQYGKDE
     GAVCLTGGED KLADLPQKFK NGFFVPPTVY TDCKKGMKIV DDEIFGPVLA VQTFETEEEA
     IELANDTAYG LGAGIFSQNA SQCMRMVHAI KAGTVWCNQY MVLSNAVPFG GMKQSGFGRE
     LGIEGLKEYT QTKAVHWNYG EEIEWPLNGT NV
//