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Protein

Histone deacetylase

Gene

PGUG_02265

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108SubstrateUniRule annotation1
Active sitei150Proton acceptorUniRule annotation1
Binding sitei158Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi185Divalent metal cationUniRule annotation1
Metal bindingi187Divalent metal cationUniRule annotation1
Metal bindingi273Divalent metal cationUniRule annotation1
Binding sitei312SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:PGUG_02265Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DG64.

Structurei

3D structure databases

ProteinModelPortaliA5DG64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 322Hist_deacetylInterPro annotationAdd BLAST286

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili485 – 507Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiA5DG64.
KOiK06067.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A5DG64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSQLPFDEI KVDESQKKRV AYFYDADVGN YAYGAGHPMK PHRIRMAHSL
60 70 80 90 100
IMNYGLYKKM EIYRAKPATK QEMCQFHTDE YIDFLSRVTP DNLDMFAKEQ
110 120 130 140 150
IKFNVGDDCP VFDGLFEYCG ISGGGSMEGA ARLNRGKCDI AINYAGGLHH
160 170 180 190 200
AKKSEASGFC YLNDIVLGII ELLRYHPRVL YIDIDVHHGD GVEEAFYTTD
210 220 230 240 250
RVMTASFHKY GEFFPGTGEL RDVGIGKGKY HAINVPLRDG IDDSSYKSIF
260 270 280 290 300
EPVIQKIMEW YQPSCVVLQC GGDSLSGDRL GCFNLSMAGH ANCINFVKSF
310 320 330 340 350
NIPMMVVGGG GYTMRNVART WAFEAGLLNN VVLPSELPYN EYYEYYGPDY
360 370 380 390 400
KLDVRPSNMY NANSPEFLNK ILTYIISNFD NTKHAPSVQM NYTPHDPEDL
410 420 430 440 450
GDVDEDTPEA YDTKGGSQQA RDEMVVAPGE HYDDREPVRN IDEVTQTNGE
460 470 480 490 500
KADQNGNPNG SNGSQNGNSN HGNQNETGNQ ETDKLSLTDE EMKAIEELNQ

EADKKED
Length:507
Mass (Da):56,956
Last modified:July 22, 2008 - v2
Checksum:i2E8A106C52023A90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408156 Genomic DNA. Translation: EDK38167.2.
RefSeqiXP_001486594.1. XM_001486544.1.

Genome annotation databases

EnsemblFungiiEDK38167; EDK38167; PGUG_02265.
GeneIDi5128086.
KEGGipgu:PGUG_02265.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA5DG64_PICGU
AccessioniPrimary (citable) accession number: A5DG64
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: July 5, 2017
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported