ID   A5DEC2_PICGU            Unreviewed;      1455 AA.
AC   A5DEC2;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 2.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Bud site selection protein 5 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PGUG_01623 {ECO:0000313|EMBL:EDK37525.2};
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK37525.2, ECO:0000313|Proteomes:UP000001997};
RN   [1] {ECO:0000313|EMBL:EDK37525.2, ECO:0000313|Proteomes:UP000001997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324 {ECO:0000313|Proteomes:UP000001997};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
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DR   EMBL; CH408156; EDK37525.2; -; Genomic_DNA.
DR   RefSeq; XP_001485952.1; XM_001485902.1.
DR   STRING; 294746.A5DEC2; -.
DR   GeneID; 5128542; -.
DR   KEGG; pgu:PGUG_01623; -.
DR   VEuPathDB; FungiDB:PGUG_01623; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_003150_0_0_1; -.
DR   InParanoid; A5DEC2; -.
DR   OMA; LYFRNFN; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          379..447
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          882..1009
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          1168..1413
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          178..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..234
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1455 AA;  164166 MW;  A1F3C3EC649D4331 CRC64;
     MPVHYSTSSS VYSPVESNFA FRRDELEQLN EDADEEYTNE QRQMNTEPST STFQTYVTAH
     SGSEQSENSL AVPGASAGVY DTTPKLDNVP DFVNDETPII GNDGFFQNGT GPSRSSLLPH
     QELHSRFKRL SVTLQSSSNG TSGDSYLFKN SFQQNVDRVN KDNNQLPYDN RTSAYYKRID
     EPYGPDSSFD DDTQIQNDAE SSVARDRSSV ISTSSFSRSS ASSSRASSIR NYVTNKERAR
     LAQDTETVTS GTDKTISNSS STNFNFNQDA SFVNFRGSRV SPTKPKAGST LEDVPIRRDL
     VYKFDQENGS KNELSEKEKN DLAIHSAAPS LVGDSYGDSS LDPRSADASH LDESSTAETT
     VDSIPNSMSS KIQVDEENLA SLFIRAIHPF DSSTLQSESD ASICLSFDKG DLAFVHTIDE
     SGWGEVTLVE SLQRGWIPMN YFTIGVEEDL DGAEPFDDDD IGAIPNSIYL KPLFHSCGKF
     LTNPLSHKNR HGKYTFSIRV INMIRDGVRL LLQETDCLSR ANEIVTKRPV VRKTRKSLLA
     DWYNLMLKAN DFKGTSNFNK IEVLTLMVYQ VIRKATAFLQ VWSIESRQIV KRDTERALQS
     DMNNHPLLPS PPQAKQRVTE INGLLYSYLG LIIGRLDLVE HNPVGCDMLE VLTHQIILLL
     RELLFISKTG SDFSAEKPAE LDDSLDSLLS LVSDLVTDVK ALVSKTLNET EEDKNVYLSK
     RANKSAGPKD YHYTAEGGAL IQIAAKMIKS ISGTVSAIRK LFEVTGDFKL NAERSYPDYA
     KMKIDPEEFV KKCTIGMVQY QDLTKKQMKE YMPAKKQASN RFSMMRRGQT GALDITPGGL
     SMLHDVMPNE NGKFGDDDAF KPFTNQSDTV KHNINDELLV DSNGNLLGAS FKGLVYTLTN
     EDSPPEYFFV STFFICFRTF TNGIDLIEEL ITRFELGNNS QNVDINYEIK LKNRRRLIVK
     MFQLWLESYW NHEADSPLLT TFINFFNEGV ANYLPLDAMK LLEVAAKLSS KPLIENQGKS
     RKAKPAKQLI TRSITVTRMN RKNATERTFV DSTLSSRYSM VDGYELSKIN TNSSTSSSLK
     SMTLPMPLGV GNQTSSANSL LTKNQLITIE NVNLTYRAIL GESWCSEKFI STKEFIPLPL
     GIMLDNWYKI CDQSWVLSNY RPNLLDFNGL EIAKQLTLVE SYIFCSIKPE ELLNENYTSK
     RAHLNLAPNV RKSVLFTNSL SSYVLESILQ PKINIKMRVN MVKTWLKVAI SCLYLRNFNS
     LAAIITALQS HLVTRLDRIW VELSDKYTEL YEYLSGIVHP NKNYNVYRTK LRNFLVANDY
     NIPIVPYFQL FLQDLTFVMD GNPNFRKANT FLNQKLINID KYLKVTRIIA DIESLQTPYG
     SQAISKEVSR NSFFGGNGKP QELEDYNIVA SPHLQELLLL EIWKVCQLNR KEDDRAWKLS
     CLIQPREGQT VNNVL
//