A5DE24 (OCA1_PICGU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase OCA1
EC=3.1.3.48

Gene names

Name:	OCA1
ORF Names:	PGUG_01525

Organism

Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) [Complete proteome]

Taxonomic identifier

294746 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Meyerozyma › Meyerozyma guilliermondii

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative tyrosine-protein phosphatase required for protection against superoxide stress By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Putative tyrosine-protein phosphatase OCA1		PRO_0000333393
Sites
	Active site	116	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5DE24 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: 382D81D40AEF31C0	FASTA	185	21,040
	10 20 30 40 50 60 MSRKVVQPPS LRIIPPLNFC PVEKQLYRSG QPSIINQSFL QDLNLKTIIW LASEEPQEEF 70 80 90 100 110 120 LDYCSMNSIN IEFVGMINDD YSYQNVNPWD SLNETTIKKA LELICDRNNY PMLVCCGMGR 130 140 150 160 170 180 HRTGTVIGCL RRLQGWNLAS VSEEYRRFTG ARGGRILVEL LIEGFDISTV EIGSGKGSSM ARKKR

References

[1]

"Evolution of pathogenicity and sexual reproduction in eight Candida genomes." Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S., Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J. , Harris D., Hoyer L.L., Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D., Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T., Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C., Birren B.W., Kellis M., Cuomo C.A. Nature 459:657-662(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408156 Genomic DNA. Translation: EDK37427.2.
RefSeq	XP_001485854.1. XM_001485804.1.
3D structure databases
ProteinModelPortal	A5DE24.
ModBase	Search...
Protein-protein interaction databases
STRING	4929.A5DE24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5128470.
KEGG	pgu:PGUG_01525.
Phylogenomic databases
eggNOG	COG2365.
OrthoDB	EOG40VZZZ.
Family and domain databases
InterPro	IPR020428. Tyr_Pase_dualsp-Pase_euk. IPR004861. Tyr_Pase_SIW14-like. [Graphical view]
Pfam	PF03162. Y_phosphatase2. 1 hit. [Graphical view]
PRINTS	PR01911. PFDSPHPHTASE.
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OCA1_PICGU

Accession

Primary (citable) accession number: A5DE24

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 10, 2009
Last modified:	April 3, 2013
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program