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Protein

Histone-lysine N-methyltransferase

Gene

PGUG_01518

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:PGUG_01518Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DE17

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 106AWSInterPro annotationAdd BLAST57
Domaini108 – 225SETInterPro annotationAdd BLAST118
Domaini232 – 248Post-SETInterPro annotationAdd BLAST17
Domaini464 – 498WWInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili527 – 552Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442 Eukaryota
COG2940 LUCA
InParanoidiA5DE17
KOiK11423
OMAiCYVDKWV
OrthoDBiEOG092C3T9B

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di1.10.1740.100, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5DE17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSASPVKK SRTPPLFLDS QDKTDEARTS FQEISECIYA NKQLGHSGQN
60 70 80 90 100
EQMTCDCHEK WDQATQRNLA CGEHSECINR ATSVECVNKS CGCGDDCQNQ
110 120 130 140 150
RFQKKEYANV SVIQTELKGY GLRANEEINE SGFIYEYVGE VINEESFRKR
160 170 180 190 200
MVEYDEKKFP HFYFMMLKKD SFIDATIKGS LARFCNHSCS PNAYVDKWVV
210 220 230 240 250
GDKLRMGIFA KRLIQAGEEI TFDYNVDRYG AQSQPCYCGE PNCIKVMGGK
260 270 280 290 300
TQTDAALLLP DGISEALGVT HQMERQWLKE NKHLRSKQQK DDSIINEAFV
310 320 330 340 350
KSIEVTPIED SEVSKVMGAL MKEQDVNITR KLVERIYLTE EPTIHSSIVR
360 370 380 390 400
MHGYKTLSQV LQTCDNDTST IIQTLTILSK WPKVTRNKIS SSQIEDVVRQ
410 420 430 440 450
LHKQSKNKKI TQLSSDLLKE WGNLQMAYRI PKNVNGERGS SSPSVYGRGA
460 470 480 490 500
RSKSPEPTEP APEEPLPEGW NMTIDPNTQK PYYYHMQLGI SRWDRPVSEP
510 520 530 540 550
PKGPSFPKGP KNEPQRKRTG NFAEDILARQ EEERLKQERE NQFKEIQQKE
560 570 580 590 600
RMLQDVILQS QRQAEEKRQA DEKARLEKLA KSRERHQKHQ KHKKNKSDNN
610 620 630 640 650
VSIEQQWAKL FAKHIPNMIK KHEKTIGHDN VKGCAKDLVK ILASKEIKKH
660 670 680 690 700
PDTAPPTELD RAKLKKIKEF SSMFMDKFLQ KYEAKRDGKR KQDNGEDEAE

AKKHKKE
Length:707
Mass (Da):81,329
Last modified:July 22, 2008 - v2
Checksum:iBBE0963B4FA7346B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408156 Genomic DNA Translation: EDK37420.2
RefSeqiXP_001485847.1, XM_001485797.1

Genome annotation databases

EnsemblFungiiEDK37420; EDK37420; PGUG_01518
GeneIDi5128463
KEGGipgu:PGUG_01518

Similar proteinsi

Entry informationi

Entry nameiA5DE17_PICGU
AccessioniPrimary (citable) accession number: A5DE17
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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