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Protein

Histone-lysine N-methyltransferase

Gene

PGUG_01518

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:PGUG_01518Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DE17.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

InParanoidiA5DE17.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DE17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSASPVKK SRTPPLFLDS QDKTDEARTS FQEISECIYA NKQLGHSGQN
60 70 80 90 100
EQMTCDCHEK WDQATQRNLA CGEHSECINR ATSVECVNKS CGCGDDCQNQ
110 120 130 140 150
RFQKKEYANV SVIQTELKGY GLRANEEINE SGFIYEYVGE VINEESFRKR
160 170 180 190 200
MVEYDEKKFP HFYFMMLKKD SFIDATIKGS LARFCNHSCS PNAYVDKWVV
210 220 230 240 250
GDKLRMGIFA KRLIQAGEEI TFDYNVDRYG AQSQPCYCGE PNCIKVMGGK
260 270 280 290 300
TQTDAALLLP DGISEALGVT HQMERQWLKE NKHLRSKQQK DDSIINEAFV
310 320 330 340 350
KSIEVTPIED SEVSKVMGAL MKEQDVNITR KLVERIYLTE EPTIHSSIVR
360 370 380 390 400
MHGYKTLSQV LQTCDNDTST IIQTLTILSK WPKVTRNKIS SSQIEDVVRQ
410 420 430 440 450
LHKQSKNKKI TQLSSDLLKE WGNLQMAYRI PKNVNGERGS SSPSVYGRGA
460 470 480 490 500
RSKSPEPTEP APEEPLPEGW NMTIDPNTQK PYYYHMQLGI SRWDRPVSEP
510 520 530 540 550
PKGPSFPKGP KNEPQRKRTG NFAEDILARQ EEERLKQERE NQFKEIQQKE
560 570 580 590 600
RMLQDVILQS QRQAEEKRQA DEKARLEKLA KSRERHQKHQ KHKKNKSDNN
610 620 630 640 650
VSIEQQWAKL FAKHIPNMIK KHEKTIGHDN VKGCAKDLVK ILASKEIKKH
660 670 680 690 700
PDTAPPTELD RAKLKKIKEF SSMFMDKFLQ KYEAKRDGKR KQDNGEDEAE

AKKHKKE
Length:707
Mass (Da):81,329
Last modified:July 22, 2008 - v2
Checksum:iBBE0963B4FA7346B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408156 Genomic DNA. Translation: EDK37420.2.
RefSeqiXP_001485847.1. XM_001485797.1.

Genome annotation databases

GeneIDi5128463.
KEGGipgu:PGUG_01518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408156 Genomic DNA. Translation: EDK37420.2.
RefSeqiXP_001485847.1. XM_001485797.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4929.A5DE17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5128463.
KEGGipgu:PGUG_01518.

Phylogenomic databases

InParanoidiA5DE17.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324Imported.

Entry informationi

Entry nameiA5DE17_PICGU
AccessioniPrimary (citable) accession number: A5DE17
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: March 4, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.