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Protein

Probable proteasome subunit beta type-4

Gene

PRO2

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.984

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-4 (EC:3.4.25.1)
Gene namesi
Name:PRO2
ORF Names:PGUG_00507
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002950321 – 194Probable proteasome subunit beta type-4Add BLAST194

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi4929.A5DB52

Structurei

3D structure databases

ProteinModelPortaliA5DB52
SMRiA5DB52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0177 Eukaryota
COG0638 LUCA
InParanoidiA5DB52
KOiK02734
OMAiQLYSMRN
OrthoDBiEOG092C3ZSC

Family and domain databases

CDDicd03758 proteasome_beta_type_2, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR035206 Proteasome_beta2
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF6 PTHR11599:SF6, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5DB52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIVLGIRVE DCTLVATSKA ATRGISVLKD TDDKTRQLNS HNLMAYSGEA
60 70 80 90 100
GDTVQFAEYI QANTQLYTMR ENDTELSPKA TASFVRNQLA TSIRSRKPYQ
110 120 130 140 150
VNVLLAGYDT NTGKPSLNWI DYLGTQVELP YAAHGYAGFY CTSLLDKHYK
160 170 180 190
KGMNFEDGLD LLKKCIKELE TRMPIDFKGC YIKVVDKEGI KLVE
Length:194
Mass (Da):21,766
Last modified:June 12, 2007 - v1
Checksum:i4D7964E1660B0634
GO

Sequence cautioni

The sequence AAN08876 differs from that shown. Reason: Frameshift at positions 16 and 23.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA Translation: EDK36409.1
AY138984 Genomic DNA Translation: AAN08876.1 Frameshift.
RefSeqiXP_001487130.1, XM_001487080.1

Genome annotation databases

EnsemblFungiiEDK36409; EDK36409; PGUG_00507
GeneIDi5129627
KEGGipgu:PGUG_00507

Similar proteinsi

Entry informationi

Entry nameiPSB4_PICGU
AccessioniPrimary (citable) accession number: A5DB52
Secondary accession number(s): Q6YJJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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