Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A5DB52 (PSB4_PICGU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence caution

The sequence AAN08876.1 differs from that shown. Reason: Frameshift at positions 16 and 23.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
Proteasome
   Molecular functionHydrolase
Protease
Threonine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis involved in cellular protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

proteasome core complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionthreonine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Probable proteasome subunit beta type-4
PRO_0000295032

Sequences

Sequence LengthMass (Da)Tools
A5DB52 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 4D7964E1660B0634

FASTA19421,766
        10         20         30         40         50         60 
MDIVLGIRVE DCTLVATSKA ATRGISVLKD TDDKTRQLNS HNLMAYSGEA GDTVQFAEYI 

        70         80         90        100        110        120 
QANTQLYTMR ENDTELSPKA TASFVRNQLA TSIRSRKPYQ VNVLLAGYDT NTGKPSLNWI 

       130        140        150        160        170        180 
DYLGTQVELP YAAHGYAGFY CTSLLDKHYK KGMNFEDGLD LLKKCIKELE TRMPIDFKGC 

       190 
YIKVVDKEGI KLVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408155 Genomic DNA. Translation: EDK36409.1.
AY138984 Genomic DNA. Translation: AAN08876.1. Frameshift.
RefSeqXP_001487130.1. XM_001487080.1.

3D structure databases

ProteinModelPortalA5DB52.
SMRA5DB52. Positions 1-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4929.A5DB52.

Protein family/group databases

MEROPST01.984.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5129627.
KEGGpgu:PGUG_00507.

Phylogenomic databases

eggNOGCOG0638.
KOK02734.
OrthoDBEOG7SJDGT.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB4_PICGU
AccessionPrimary (citable) accession number: A5DB52
Secondary accession number(s): Q6YJJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries