Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5DB51

- RISA_PICGU

UniProt

A5DB51 - RISA_PICGU

Protein

Riboflavin synthase

Gene

RIB5

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 3 (10 Feb 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

    Catalytic activityi

    2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity Source: InterPro
    2. riboflavin synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00275; UER00405.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin synthase (EC:2.5.1.9)
    Short name:
    RS
    Gene namesi
    Name:RIB5
    Synonyms:RIB7
    ORF Names:PGUG_00506
    OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
    Taxonomic identifieri294746 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
    ProteomesiUP000001997: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Riboflavin synthasePRO_0000295039Add
    BLAST

    Expressioni

    Inductioni

    Repressed by iron.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi4929.A5DB51.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 105105Lumazine-binding 1Add
    BLAST
    Repeati106 – 205100Lumazine-binding 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 935Lumazine bindingCurated
    Regioni189 – 1935Lumazine bindingCurated

    Sequence similaritiesi

    Contains 2 lumazine-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0307.
    KOiK00793.
    OrthoDBiEOG793BMH.

    Family and domain databases

    Gene3Di2.40.30.20. 2 hits.
    InterProiIPR023366. ATPase_asu-like.
    IPR001783. Lumazine-bd.
    IPR026017. Lumazine-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PANTHERiPTHR21098. PTHR21098. 1 hit.
    PfamiPF00677. Lum_binding. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
    SUPFAMiSSF63380. SSF63380. 2 hits.
    TIGRFAMsiTIGR00187. ribE. 1 hit.
    PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5DB51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTGLVEHIG TVLQVTEKDT TASGGDGVSM VIGDCSKILE DVQLGDSICT    50
    NGVCLTVTEF DMARSQFKVG ISPETLRRSD LGELKPGSKV NLERAVKADV 100
    RMGGHVVQGH VDTIATIVNR RGDGNAINFT FKLRDSQYGK YIVEKGFIAI 150
    DGTSLTVTDV DHEQSEFSIS MVSYTQEKVI MPLKNSGDSV NIEVDLTGKL 200
    IEKQIELSLL SYIKDETSPL STLIGKLVEK KVDDVLKRN 239
    Length:239
    Mass (Da):26,044
    Last modified:February 10, 2009 - v3
    Checksum:i64DA06FEFB2D59B2
    GO

    Sequence cautioni

    The sequence EDK36408.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF459790 Genomic DNA. Translation: AAL66353.2.
    AY138984 Genomic DNA. Translation: AAN08875.2.
    CH408155 Genomic DNA. Translation: EDK36408.2. Different initiation.
    RefSeqiXP_001487129.1. XM_001487079.1.

    Genome annotation databases

    GeneIDi5129626.
    KEGGipgu:PGUG_00506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF459790 Genomic DNA. Translation: AAL66353.2 .
    AY138984 Genomic DNA. Translation: AAN08875.2 .
    CH408155 Genomic DNA. Translation: EDK36408.2 . Different initiation.
    RefSeqi XP_001487129.1. XM_001487079.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4929.A5DB51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5129626.
    KEGGi pgu:PGUG_00506.

    Phylogenomic databases

    eggNOGi COG0307.
    KOi K00793.
    OrthoDBi EOG793BMH.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00405 .

    Family and domain databases

    Gene3Di 2.40.30.20. 2 hits.
    InterProi IPR023366. ATPase_asu-like.
    IPR001783. Lumazine-bd.
    IPR026017. Lumazine-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    PANTHERi PTHR21098. PTHR21098. 1 hit.
    Pfami PF00677. Lum_binding. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000498. Riboflavin_syn_A. 1 hit.
    SUPFAMi SSF63380. SSF63380. 2 hits.
    TIGRFAMsi TIGR00187. ribE. 1 hit.
    PROSITEi PS51177. LUMAZINE_BIND. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection of mutants defective in transcriptional repression of riboflavin synthesis by iron in the flavinogenic yeast Pichia guilliermondii."
      Boretsky Y.R., Kapustyak K.Y., Fayura L.R., Stasyk O.V., Stenchuk M.M., Bobak Y.P., Drobot L.B., Sibirny A.A.
      FEMS Yeast Res. 5:829-837(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

    Entry informationi

    Entry nameiRISA_PICGU
    AccessioniPrimary (citable) accession number: A5DB51
    Secondary accession number(s): Q8X181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3