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A5DAT0 (KEX1_PICGU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:PGUG_00385
OrganismMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) [Complete proteome]
Taxonomic identifier294746 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 656639Pheromone-processing carboxypeptidase KEX1
PRO_0000411938

Regions

Topological domain18 – 536519Lumenal Potential
Transmembrane537 – 55721Helical; Potential
Topological domain558 – 65699Cytoplasmic Potential
Compositional bias642 – 6454Poly-Glu

Sites

Active site1801 By similarity
Active site3881 By similarity
Active site4451 By similarity

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A5DAT0 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 0A0643FE4686AA27

FASTA65673,287
        10         20         30         40         50         60 
MFFHAILVLI QVALALGASP RAGSSERSKY FVTSLPGMYS NLPKEEIPIM FSGQLELFPE 

        70         80         90        100        110        120 
NNTHYYFWKF VNPNPIAEAE RRTIFWLNGG PGCSSMDGAL MEAGPFRVND DKEIVYNNGS 

       130        140        150        160        170        180 
WHKAGDIVFV DQPAGTGFSY SDEYEHELPD VSVHFLKFLE KYFEVFPEDR QNQIFFAGES 

       190        200        210        220        230        240 
YAGQYIPYIA DGILKRNKNL KAGESPYDLR GLLIGNGWIA PNEQSLSYVQ YALQAGFVSP 

       250        260        270        280        290        300 
SMPGWSRLLA SQERCQNVVN SVNTQDDSVS DYKVVSDVCD QVLNTLLEVA RDRDAPADQQ 

       310        320        330        340        350        360 
CVNMYDYTLR DEFPSCGMNW PPDLVNVKPF LNIPGVQSQL NLVHKKPWLE CSGRVGRNFV 

       370        380        390        400        410        420 
AQRSKPAVHL LPSLLEDVPI LLFNGNRDII CNYIGTEAFI KELEWNGQKG WDDDNVFDWN 

       430        440        450        460        470        480 
FDGNLAGYVR NSRNLTFVNV FNSSHMVPFD LPDTSRSLMD LVTGNFDIKD DKILTYKLGT 

       490        500        510        520        530        540 
RGQAKQSDKK PASTSSIPSE ISATALASGS SSASAQASAT ANEADGDNNT SHKIERAIQL 

       550        560        570        580        590        600 
LVIIVLLWGI YALYSSYKSR PSSIIKSGPT GKKKNVQWAD QLRRFQEDDQ VRVQPHGIFA 

       610        620        630        640        650 
KALNKFKGNS DGAYAPVQGR YEDIEMSSAS PIDDFVVVSD DEEEEPSRNE PSSNQK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408155 Genomic DNA. Translation: EDK36287.2.
RefSeqXP_001487008.1. XM_001486958.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4929.A5DAT0.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5129177.
KEGGpgu:PGUG_00385.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PICGU
AccessionPrimary (citable) accession number: A5DAT0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 22, 2008
Last modified: June 11, 2014
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries