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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei180PROSITE-ProRule annotation1
Active sitei388PROSITE-ProRule annotation1
Active sitei445PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PGUG_00385
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 536LumenalSequence analysisAdd BLAST519
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 656CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000041193818 – 656Pheromone-processing carboxypeptidase KEX1Add BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DAT0.

Structurei

3D structure databases

SMRiA5DAT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi642 – 645Poly-Glu4

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiA5DAT0.
KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiView protein in Pfam
PF00450. Peptidase_S10. 1 hit.
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00560. CARBOXYPEPT_SER_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5DAT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFHAILVLI QVALALGASP RAGSSERSKY FVTSLPGMYS NLPKEEIPIM
60 70 80 90 100
FSGQLELFPE NNTHYYFWKF VNPNPIAEAE RRTIFWLNGG PGCSSMDGAL
110 120 130 140 150
MEAGPFRVND DKEIVYNNGS WHKAGDIVFV DQPAGTGFSY SDEYEHELPD
160 170 180 190 200
VSVHFLKFLE KYFEVFPEDR QNQIFFAGES YAGQYIPYIA DGILKRNKNL
210 220 230 240 250
KAGESPYDLR GLLIGNGWIA PNEQSLSYVQ YALQAGFVSP SMPGWSRLLA
260 270 280 290 300
SQERCQNVVN SVNTQDDSVS DYKVVSDVCD QVLNTLLEVA RDRDAPADQQ
310 320 330 340 350
CVNMYDYTLR DEFPSCGMNW PPDLVNVKPF LNIPGVQSQL NLVHKKPWLE
360 370 380 390 400
CSGRVGRNFV AQRSKPAVHL LPSLLEDVPI LLFNGNRDII CNYIGTEAFI
410 420 430 440 450
KELEWNGQKG WDDDNVFDWN FDGNLAGYVR NSRNLTFVNV FNSSHMVPFD
460 470 480 490 500
LPDTSRSLMD LVTGNFDIKD DKILTYKLGT RGQAKQSDKK PASTSSIPSE
510 520 530 540 550
ISATALASGS SSASAQASAT ANEADGDNNT SHKIERAIQL LVIIVLLWGI
560 570 580 590 600
YALYSSYKSR PSSIIKSGPT GKKKNVQWAD QLRRFQEDDQ VRVQPHGIFA
610 620 630 640 650
KALNKFKGNS DGAYAPVQGR YEDIEMSSAS PIDDFVVVSD DEEEEPSRNE

PSSNQK
Length:656
Mass (Da):73,287
Last modified:July 22, 2008 - v2
Checksum:i0A0643FE4686AA27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA. Translation: EDK36287.2.
RefSeqiXP_001487008.1. XM_001486958.1.

Genome annotation databases

EnsemblFungiiEDK36287; EDK36287; PGUG_00385.
GeneIDi5129177.
KEGGipgu:PGUG_00385.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKEX1_PICGU
AccessioniPrimary (citable) accession number: A5DAT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 22, 2008
Last modified: July 5, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families