SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A5DAT0

- KEX1_PICGU

UniProt

A5DAT0 - KEX1_PICGU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, PGUG_00385
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801 By similarity
Active sitei388 – 3881 By similarity
Active sitei445 – 4451 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PGUG_00385
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 536519Lumenal Reviewed prediction
Add
BLAST
Transmembranei537 – 55721Helical; Reviewed prediction
Add
BLAST
Topological domaini558 – 65699Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 656639Pheromone-processing carboxypeptidase KEX1
PRO_0000411938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi4929.A5DAT0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi642 – 6454Poly-Glu

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5DAT0-1 [UniParc]FASTAAdd to Basket

« Hide

MFFHAILVLI QVALALGASP RAGSSERSKY FVTSLPGMYS NLPKEEIPIM    50
FSGQLELFPE NNTHYYFWKF VNPNPIAEAE RRTIFWLNGG PGCSSMDGAL 100
MEAGPFRVND DKEIVYNNGS WHKAGDIVFV DQPAGTGFSY SDEYEHELPD 150
VSVHFLKFLE KYFEVFPEDR QNQIFFAGES YAGQYIPYIA DGILKRNKNL 200
KAGESPYDLR GLLIGNGWIA PNEQSLSYVQ YALQAGFVSP SMPGWSRLLA 250
SQERCQNVVN SVNTQDDSVS DYKVVSDVCD QVLNTLLEVA RDRDAPADQQ 300
CVNMYDYTLR DEFPSCGMNW PPDLVNVKPF LNIPGVQSQL NLVHKKPWLE 350
CSGRVGRNFV AQRSKPAVHL LPSLLEDVPI LLFNGNRDII CNYIGTEAFI 400
KELEWNGQKG WDDDNVFDWN FDGNLAGYVR NSRNLTFVNV FNSSHMVPFD 450
LPDTSRSLMD LVTGNFDIKD DKILTYKLGT RGQAKQSDKK PASTSSIPSE 500
ISATALASGS SSASAQASAT ANEADGDNNT SHKIERAIQL LVIIVLLWGI 550
YALYSSYKSR PSSIIKSGPT GKKKNVQWAD QLRRFQEDDQ VRVQPHGIFA 600
KALNKFKGNS DGAYAPVQGR YEDIEMSSAS PIDDFVVVSD DEEEEPSRNE 650
PSSNQK 656
Length:656
Mass (Da):73,287
Last modified:July 22, 2008 - v2
Checksum:i0A0643FE4686AA27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408155 Genomic DNA. Translation: EDK36287.2.
RefSeqiXP_001487008.1. XM_001486958.1.

Genome annotation databases

GeneIDi5129177.
KEGGipgu:PGUG_00385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408155 Genomic DNA. Translation: EDK36287.2 .
RefSeqi XP_001487008.1. XM_001486958.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4929.A5DAT0.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5129177.
KEGGi pgu:PGUG_00385.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiKEX1_PICGU
AccessioniPrimary (citable) accession number: A5DAT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 22, 2008
Last modified: June 11, 2014
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi