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A5DAL6

- A5DAL6_PICGU

UniProt

A5DAL6 - A5DAL6_PICGU

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene
PGUG_00321
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:PGUG_00321Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi4929.A5DAL6.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Phylogenomic databases

KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DAL6-1 [UniParc]FASTAAdd to Basket

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MSYRFKGPDR GDRGDRNDRG GGYHTNYDDK YRREVAPKLS NSYDSFRPSG     50
PRKHNTNHYD RDAYYRPMEH RNPSKPAQTP STNPKPEFKP DHEQENGRHS 100
HHGNVQNHTR SPLQPPTPNS VTSAPEEVTG TDPRTGVNPH DLKVPTLQLH 150
RDHLQLEFSS PSDPPKNYKV LYDPENDSHR NKSTNKSKSK VFRFNGSSVS 200
DPQSYSDAII HSSDITDPRK KILSTYFSKP NKNSKKFPFK QLPQPRFVFD 250
KNSVGPPPQT ELVVWDIPST TSEVYVTNFF RSHGNATEIN FLQDPMYAVP 300
LGVMSFRFQG SPDKSMLLAK NLLNFVHLEK PKINGVVLKI ELNDHEGKLL 350
RSKVEIAQNR IRQSKQKLEM EEQKRREMEE EKKRKEIVAQ REEARQKESQ 400
NNTFQKYDYK PNTTIMSVKY RNKVIPGTFL PREVRHIIKD NPYLFIHDKH 450
VSTRTVSAQD IKRVLNKYNW SRVLHEKVGF FIIFNSLEEC KRCFWKEDGR 500
RFYEFRMFME MAVPEGFEDK STTSATKGDA VEEATNMLIQ EFQAYLKKDI 550
RERVIAPQVL ELLNPERFPV LKAQLDEERT KQAQAAAARA ETIASKIQET 600
RNKEGAYALM NKKAAQLPSF KRKEGIKMQA KKRVIPMQHV LNYENDSDDS 650
EDDSSRSATP APALKRERSS PATSYDEEAP SKKKKKTSLK TMLLYDSSEG 700
EVSDSPEDQV MEDAEEAADQ VDDFADVDVK FRPTLHSSVP VYPEDEFVDE 750
FDVNYIQSSI KDEEDLNIAK SILSELKPST IANVDYWAWK QKETRKPEEI 800
AESVHLIEPL APKFESASGS FRSEGYRKIP DTDKIEYLPH RRKIYKPVKT 850
VQHEDDETSA NNGNGTNNST AVHSSRVNRA NNRRLVADIS AQKQMLGSET 900
DILDLNALTK RKKPVTFARS AIHNWGLYAL ESIAAKEMII EYVGESIRQQ 950
VAEHREKSYL KTGIGSSYLF RIDENSVIDA TKKGGIARFI NHCCNPSCTA 1000
KIIKVEGKKR IVIYALRDIE ANEELTYDYK FERETNDDER IRCLCGAPGC 1050
KGYLN 1055
Length:1,055
Mass (Da):121,185
Last modified:July 22, 2008 - v2
Checksum:i4C274A3D2E56CFAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408155 Genomic DNA. Translation: EDK36223.2.
RefSeqiXP_001486944.1. XM_001486894.1.

Genome annotation databases

GeneIDi5128987.
KEGGipgu:PGUG_00321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408155 Genomic DNA. Translation: EDK36223.2 .
RefSeqi XP_001486944.1. XM_001486894.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4929.A5DAL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5128987.
KEGGi pgu:PGUG_00321.

Phylogenomic databases

KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324.

Entry informationi

Entry nameiA5DAL6_PICGU
AccessioniPrimary (citable) accession number: A5DAL6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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