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A5DAL6 (A5DAL6_PICGU) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1055 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity. PIRNR PIRNR037104

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037104 SAAS SAAS001214

Subunit structure

Component of the COMPASS (Set1C) complex By similarity. PIRNR PIRNR037104

Subcellular location

Nucleus By similarity PIRNR PIRNR037104.

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Sequences

Sequence LengthMass (Da)Tools
A5DAL6 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 4C274A3D2E56CFAE

FASTA1,055121,185
        10         20         30         40         50         60 
MSYRFKGPDR GDRGDRNDRG GGYHTNYDDK YRREVAPKLS NSYDSFRPSG PRKHNTNHYD 

        70         80         90        100        110        120 
RDAYYRPMEH RNPSKPAQTP STNPKPEFKP DHEQENGRHS HHGNVQNHTR SPLQPPTPNS 

       130        140        150        160        170        180 
VTSAPEEVTG TDPRTGVNPH DLKVPTLQLH RDHLQLEFSS PSDPPKNYKV LYDPENDSHR 

       190        200        210        220        230        240 
NKSTNKSKSK VFRFNGSSVS DPQSYSDAII HSSDITDPRK KILSTYFSKP NKNSKKFPFK 

       250        260        270        280        290        300 
QLPQPRFVFD KNSVGPPPQT ELVVWDIPST TSEVYVTNFF RSHGNATEIN FLQDPMYAVP 

       310        320        330        340        350        360 
LGVMSFRFQG SPDKSMLLAK NLLNFVHLEK PKINGVVLKI ELNDHEGKLL RSKVEIAQNR 

       370        380        390        400        410        420 
IRQSKQKLEM EEQKRREMEE EKKRKEIVAQ REEARQKESQ NNTFQKYDYK PNTTIMSVKY 

       430        440        450        460        470        480 
RNKVIPGTFL PREVRHIIKD NPYLFIHDKH VSTRTVSAQD IKRVLNKYNW SRVLHEKVGF 

       490        500        510        520        530        540 
FIIFNSLEEC KRCFWKEDGR RFYEFRMFME MAVPEGFEDK STTSATKGDA VEEATNMLIQ 

       550        560        570        580        590        600 
EFQAYLKKDI RERVIAPQVL ELLNPERFPV LKAQLDEERT KQAQAAAARA ETIASKIQET 

       610        620        630        640        650        660 
RNKEGAYALM NKKAAQLPSF KRKEGIKMQA KKRVIPMQHV LNYENDSDDS EDDSSRSATP 

       670        680        690        700        710        720 
APALKRERSS PATSYDEEAP SKKKKKTSLK TMLLYDSSEG EVSDSPEDQV MEDAEEAADQ 

       730        740        750        760        770        780 
VDDFADVDVK FRPTLHSSVP VYPEDEFVDE FDVNYIQSSI KDEEDLNIAK SILSELKPST 

       790        800        810        820        830        840 
IANVDYWAWK QKETRKPEEI AESVHLIEPL APKFESASGS FRSEGYRKIP DTDKIEYLPH 

       850        860        870        880        890        900 
RRKIYKPVKT VQHEDDETSA NNGNGTNNST AVHSSRVNRA NNRRLVADIS AQKQMLGSET 

       910        920        930        940        950        960 
DILDLNALTK RKKPVTFARS AIHNWGLYAL ESIAAKEMII EYVGESIRQQ VAEHREKSYL 

       970        980        990       1000       1010       1020 
KTGIGSSYLF RIDENSVIDA TKKGGIARFI NHCCNPSCTA KIIKVEGKKR IVIYALRDIE 

      1030       1040       1050 
ANEELTYDYK FERETNDDER IRCLCGAPGC KGYLN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408155 Genomic DNA. Translation: EDK36223.2.
RefSeqXP_001486944.1. XM_001486894.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4929.A5DAL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5128987.
KEGGpgu:PGUG_00321.

Phylogenomic databases

KOK11422.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5DAL6_PICGU
AccessionPrimary (citable) accession number: A5DAL6
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)