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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

PGUG_00321

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:PGUG_00321Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
ProteomesiUP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi4929.A5DAL6.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

InParanoidiA5DAL6.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5DAL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRFKGPDR GDRGDRNDRG GGYHTNYDDK YRREVAPKLS NSYDSFRPSG
60 70 80 90 100
PRKHNTNHYD RDAYYRPMEH RNPSKPAQTP STNPKPEFKP DHEQENGRHS
110 120 130 140 150
HHGNVQNHTR SPLQPPTPNS VTSAPEEVTG TDPRTGVNPH DLKVPTLQLH
160 170 180 190 200
RDHLQLEFSS PSDPPKNYKV LYDPENDSHR NKSTNKSKSK VFRFNGSSVS
210 220 230 240 250
DPQSYSDAII HSSDITDPRK KILSTYFSKP NKNSKKFPFK QLPQPRFVFD
260 270 280 290 300
KNSVGPPPQT ELVVWDIPST TSEVYVTNFF RSHGNATEIN FLQDPMYAVP
310 320 330 340 350
LGVMSFRFQG SPDKSMLLAK NLLNFVHLEK PKINGVVLKI ELNDHEGKLL
360 370 380 390 400
RSKVEIAQNR IRQSKQKLEM EEQKRREMEE EKKRKEIVAQ REEARQKESQ
410 420 430 440 450
NNTFQKYDYK PNTTIMSVKY RNKVIPGTFL PREVRHIIKD NPYLFIHDKH
460 470 480 490 500
VSTRTVSAQD IKRVLNKYNW SRVLHEKVGF FIIFNSLEEC KRCFWKEDGR
510 520 530 540 550
RFYEFRMFME MAVPEGFEDK STTSATKGDA VEEATNMLIQ EFQAYLKKDI
560 570 580 590 600
RERVIAPQVL ELLNPERFPV LKAQLDEERT KQAQAAAARA ETIASKIQET
610 620 630 640 650
RNKEGAYALM NKKAAQLPSF KRKEGIKMQA KKRVIPMQHV LNYENDSDDS
660 670 680 690 700
EDDSSRSATP APALKRERSS PATSYDEEAP SKKKKKTSLK TMLLYDSSEG
710 720 730 740 750
EVSDSPEDQV MEDAEEAADQ VDDFADVDVK FRPTLHSSVP VYPEDEFVDE
760 770 780 790 800
FDVNYIQSSI KDEEDLNIAK SILSELKPST IANVDYWAWK QKETRKPEEI
810 820 830 840 850
AESVHLIEPL APKFESASGS FRSEGYRKIP DTDKIEYLPH RRKIYKPVKT
860 870 880 890 900
VQHEDDETSA NNGNGTNNST AVHSSRVNRA NNRRLVADIS AQKQMLGSET
910 920 930 940 950
DILDLNALTK RKKPVTFARS AIHNWGLYAL ESIAAKEMII EYVGESIRQQ
960 970 980 990 1000
VAEHREKSYL KTGIGSSYLF RIDENSVIDA TKKGGIARFI NHCCNPSCTA
1010 1020 1030 1040 1050
KIIKVEGKKR IVIYALRDIE ANEELTYDYK FERETNDDER IRCLCGAPGC

KGYLN
Length:1,055
Mass (Da):121,185
Last modified:July 22, 2008 - v2
Checksum:i4C274A3D2E56CFAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA. Translation: EDK36223.2.
RefSeqiXP_001486944.1. XM_001486894.1.

Genome annotation databases

GeneIDi5128987.
KEGGipgu:PGUG_00321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA. Translation: EDK36223.2.
RefSeqiXP_001486944.1. XM_001486894.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4929.A5DAL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5128987.
KEGGipgu:PGUG_00321.

Phylogenomic databases

InParanoidiA5DAL6.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324Imported.

Entry informationi

Entry nameiA5DAL6_PICGU
AccessioniPrimary (citable) accession number: A5DAL6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: April 1, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.