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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

PGUG_00321

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:PGUG_00321Imported
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi4929.A5DAL6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini913 – 1030SETInterPro annotationAdd BLAST118
Domaini1039 – 1055Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili354 – 400Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1080 Eukaryota
COG2940 LUCA
InParanoidiA5DAL6
KOiK11422
OMAiPSCTAKI
OrthoDBiEOG092C3T9B

Family and domain databases

InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR003616 Post-SET_dom
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PANTHERiPTHR22884:SF462 PTHR22884:SF462, 3 hits
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

A5DAL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRFKGPDR GDRGDRNDRG GGYHTNYDDK YRREVAPKLS NSYDSFRPSG
60 70 80 90 100
PRKHNTNHYD RDAYYRPMEH RNPSKPAQTP STNPKPEFKP DHEQENGRHS
110 120 130 140 150
HHGNVQNHTR SPLQPPTPNS VTSAPEEVTG TDPRTGVNPH DLKVPTLQLH
160 170 180 190 200
RDHLQLEFSS PSDPPKNYKV LYDPENDSHR NKSTNKSKSK VFRFNGSSVS
210 220 230 240 250
DPQSYSDAII HSSDITDPRK KILSTYFSKP NKNSKKFPFK QLPQPRFVFD
260 270 280 290 300
KNSVGPPPQT ELVVWDIPST TSEVYVTNFF RSHGNATEIN FLQDPMYAVP
310 320 330 340 350
LGVMSFRFQG SPDKSMLLAK NLLNFVHLEK PKINGVVLKI ELNDHEGKLL
360 370 380 390 400
RSKVEIAQNR IRQSKQKLEM EEQKRREMEE EKKRKEIVAQ REEARQKESQ
410 420 430 440 450
NNTFQKYDYK PNTTIMSVKY RNKVIPGTFL PREVRHIIKD NPYLFIHDKH
460 470 480 490 500
VSTRTVSAQD IKRVLNKYNW SRVLHEKVGF FIIFNSLEEC KRCFWKEDGR
510 520 530 540 550
RFYEFRMFME MAVPEGFEDK STTSATKGDA VEEATNMLIQ EFQAYLKKDI
560 570 580 590 600
RERVIAPQVL ELLNPERFPV LKAQLDEERT KQAQAAAARA ETIASKIQET
610 620 630 640 650
RNKEGAYALM NKKAAQLPSF KRKEGIKMQA KKRVIPMQHV LNYENDSDDS
660 670 680 690 700
EDDSSRSATP APALKRERSS PATSYDEEAP SKKKKKTSLK TMLLYDSSEG
710 720 730 740 750
EVSDSPEDQV MEDAEEAADQ VDDFADVDVK FRPTLHSSVP VYPEDEFVDE
760 770 780 790 800
FDVNYIQSSI KDEEDLNIAK SILSELKPST IANVDYWAWK QKETRKPEEI
810 820 830 840 850
AESVHLIEPL APKFESASGS FRSEGYRKIP DTDKIEYLPH RRKIYKPVKT
860 870 880 890 900
VQHEDDETSA NNGNGTNNST AVHSSRVNRA NNRRLVADIS AQKQMLGSET
910 920 930 940 950
DILDLNALTK RKKPVTFARS AIHNWGLYAL ESIAAKEMII EYVGESIRQQ
960 970 980 990 1000
VAEHREKSYL KTGIGSSYLF RIDENSVIDA TKKGGIARFI NHCCNPSCTA
1010 1020 1030 1040 1050
KIIKVEGKKR IVIYALRDIE ANEELTYDYK FERETNDDER IRCLCGAPGC

KGYLN
Length:1,055
Mass (Da):121,185
Last modified:July 22, 2008 - v2
Checksum:i4C274A3D2E56CFAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA Translation: EDK36223.2
RefSeqiXP_001486944.1, XM_001486894.1

Genome annotation databases

EnsemblFungiiEDK36223; EDK36223; PGUG_00321
GeneIDi5128987
KEGGipgu:PGUG_00321

Entry informationi

Entry nameiA5DAL6_PICGU
AccessioniPrimary (citable) accession number: A5DAL6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health