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A5DAL6

- A5DAL6_PICGU

UniProt

A5DAL6 - A5DAL6_PICGU

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

PGUG_00321

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    ORF Names:PGUG_00321Imported
    OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
    Taxonomic identifieri294746 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
    ProteomesiUP000001997: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi4929.A5DAL6.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5DAL6-1 [UniParc]FASTAAdd to Basket

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    MSYRFKGPDR GDRGDRNDRG GGYHTNYDDK YRREVAPKLS NSYDSFRPSG     50
    PRKHNTNHYD RDAYYRPMEH RNPSKPAQTP STNPKPEFKP DHEQENGRHS 100
    HHGNVQNHTR SPLQPPTPNS VTSAPEEVTG TDPRTGVNPH DLKVPTLQLH 150
    RDHLQLEFSS PSDPPKNYKV LYDPENDSHR NKSTNKSKSK VFRFNGSSVS 200
    DPQSYSDAII HSSDITDPRK KILSTYFSKP NKNSKKFPFK QLPQPRFVFD 250
    KNSVGPPPQT ELVVWDIPST TSEVYVTNFF RSHGNATEIN FLQDPMYAVP 300
    LGVMSFRFQG SPDKSMLLAK NLLNFVHLEK PKINGVVLKI ELNDHEGKLL 350
    RSKVEIAQNR IRQSKQKLEM EEQKRREMEE EKKRKEIVAQ REEARQKESQ 400
    NNTFQKYDYK PNTTIMSVKY RNKVIPGTFL PREVRHIIKD NPYLFIHDKH 450
    VSTRTVSAQD IKRVLNKYNW SRVLHEKVGF FIIFNSLEEC KRCFWKEDGR 500
    RFYEFRMFME MAVPEGFEDK STTSATKGDA VEEATNMLIQ EFQAYLKKDI 550
    RERVIAPQVL ELLNPERFPV LKAQLDEERT KQAQAAAARA ETIASKIQET 600
    RNKEGAYALM NKKAAQLPSF KRKEGIKMQA KKRVIPMQHV LNYENDSDDS 650
    EDDSSRSATP APALKRERSS PATSYDEEAP SKKKKKTSLK TMLLYDSSEG 700
    EVSDSPEDQV MEDAEEAADQ VDDFADVDVK FRPTLHSSVP VYPEDEFVDE 750
    FDVNYIQSSI KDEEDLNIAK SILSELKPST IANVDYWAWK QKETRKPEEI 800
    AESVHLIEPL APKFESASGS FRSEGYRKIP DTDKIEYLPH RRKIYKPVKT 850
    VQHEDDETSA NNGNGTNNST AVHSSRVNRA NNRRLVADIS AQKQMLGSET 900
    DILDLNALTK RKKPVTFARS AIHNWGLYAL ESIAAKEMII EYVGESIRQQ 950
    VAEHREKSYL KTGIGSSYLF RIDENSVIDA TKKGGIARFI NHCCNPSCTA 1000
    KIIKVEGKKR IVIYALRDIE ANEELTYDYK FERETNDDER IRCLCGAPGC 1050
    KGYLN 1055
    Length:1,055
    Mass (Da):121,185
    Last modified:July 22, 2008 - v2
    Checksum:i4C274A3D2E56CFAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408155 Genomic DNA. Translation: EDK36223.2.
    RefSeqiXP_001486944.1. XM_001486894.1.

    Genome annotation databases

    GeneIDi5128987.
    KEGGipgu:PGUG_00321.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408155 Genomic DNA. Translation: EDK36223.2 .
    RefSeqi XP_001486944.1. XM_001486894.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4929.A5DAL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5128987.
    KEGGi pgu:PGUG_00321.

    Phylogenomic databases

    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324Imported.

    Entry informationi

    Entry nameiA5DAL6_PICGU
    AccessioniPrimary (citable) accession number: A5DAL6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3